INT151588

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Context Info
Confidence 0.73
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 48
Total Number 50
Disease Relevance 15.62
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkag1) protein complex (Prkag1) response to stress (Prkag1)
Anatomy Link Frequency
plasma 1
cardiomyocytes 1
skeletal muscles 1
myotube 1
Prkag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 35 99.76 Very High Very High Very High
agonist 186 99.38 Very High Very High Very High
cytokine 121 93.24 High High
alcohol 180 90.48 High High
ischemia 56 87.48 High High
tolerance 149 85.44 High High
Cannabinoid 33 79.44 Quite High
Inflammation 94 78.68 Quite High
Kinase C 11 51.04 Quite High
Intracerebroventricular 1 31.68 Quite Low
Disease Link Frequency Relevance Heat
Tuberous Sclerosis 5 99.96 Very High Very High Very High
Starvation 5 99.96 Very High Very High Very High
Aging 1489 99.84 Very High Very High Very High
Obesity 2256 99.36 Very High Very High Very High
Diabetes Mellitus 253 97.32 Very High Very High Very High
Hyperlipidemia 38 96.88 Very High Very High Very High
Impaired Glucose Tolerance 191 93.44 High High
Targeted Disruption 134 91.76 High High
Toxicity 105 90.96 High High
Repression 1 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In L6 myotube cells, phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) and glucose uptake were significantly increased, whereas these effects were attenuated by an AMPK inhibitor, compound C.
Phosphorylation (phosphorylation) of AMPK in myotube
1) Confidence 0.73 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18435912 Disease Relevance 0.16 Pain Relevance 0
In addition, increased phosphorylation of AMPK and ACC by isodihydrocapsiate was significantly reduced by radicicol, an LKB1 destabilizer, suggesting that increased glucose uptake in L6 cells with isodihydrocapsiate treatment is predominantly accomplished by a LKB1-mediated AMPK activation pathway.
Phosphorylation (phosphorylation) of AMPK
2) Confidence 0.63 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18435912 Disease Relevance 0.17 Pain Relevance 0
Under the condition of starvation, AMPK phosphorylates tuberous sclerosis 2 (TSC2), which inhibits mTOR/S6K1 pathway [39]: phosphorylation of TSC2 by AMPK is critical in the process of mRNA translation and cell size regulation during energy deficiency (Figure 2).
Phosphorylation (phosphorylation) of AMPK associated with starvation and tuberous sclerosis
3) Confidence 0.54 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.34 Pain Relevance 0.03
Under the condition of starvation, AMPK phosphorylates tuberous sclerosis 2 (TSC2), which inhibits mTOR/S6K1 pathway [39]: phosphorylation of TSC2 by AMPK is critical in the process of mRNA translation and cell size regulation during energy deficiency (Figure 2).
Phosphorylation (phosphorylates) of AMPK associated with starvation and tuberous sclerosis
4) Confidence 0.54 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.32 Pain Relevance 0.06
More interestingly, the ADH and/or acute ethanol-induced cardiac contractile and intracellular Ca2+ responses were coordinated with hyperactivated AMPK signaling cascade including phosphorylation of AMPK, ACC and LKB1 as well as downregulation of protein phosphatase PP2A subunit and PPAR-?.
Phosphorylation (phosphorylation) of AMPK
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.40 Pain Relevance 0.08
Although data from our present study fail to provide any precise mechanism of action behind the hyperphosphorylated LKB1/AMPK signaling cascade, accumulation of reactive oxygen species in response to ethanol exposure is believed to play an important role.
Phosphorylation (hyperphosphorylated) of AMPK
6) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.32 Pain Relevance 0.03
In summary, the present study has provided convincing evidence that cardiac overexpression of ADH exacerbated acute ethanol exposure-induced myocardial contractile and intracellular Ca2+ dysregulation associated with altered insulin sensitivity and hyperphosphorylated AMPK signaling.
Phosphorylation (hyperphosphorylated) of AMPK
7) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.31 Pain Relevance 0
ADH transgene itself did not elicit any effect on the phosphorylation of AMPK and ACC (Fig. 7).
Phosphorylation (phosphorylation) of AMPK
8) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
, anti-Glut4, anti-AMPK, anti-phosphorylated AMPK (pAMPK, Thr172), anti-ACC, anti-phosphorylated ACC (pACC, Ser79), anti-LKB1, anti-phosphorylated LKB1 (pLKB1, Ser428), anti-PP2AA, anti-PP2AB, anti-PP2C?
Phosphorylation (phosphorylated) of AMPK
9) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
Second, AMP activates the AMPK upstream kinase LKB1 to phosphorylate ?
Phosphorylation (phosphorylate) of AMPK
10) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.21 Pain Relevance 0.07
Our findings suggest that the phosphorylation of AMPK at Thr172 may be influenced by the expression of PP2A but less likely PP2C?
Phosphorylation (phosphorylation) of AMPK
11) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.29 Pain Relevance 0.04
However, phosphorylation of both AMPK and ACC was increased by acute ethanol exposure (both absolute value and phosphorylated-to-pan protein ratio), the effect of which was accentuated by ADH.
Phosphorylation (phosphorylation) of AMPK
12) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.06 Pain Relevance 0.03
In line with its effect on AMPK and ACC phosphorylation, acute ethanol challenge enhanced the phosphorylation of LKB1 (both absolute and pLKB1/LKB1 ratio), the effect of which was augmented by ADH transgene.
Phosphorylation (phosphorylation) of AMPK
13) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
, anti-Glut4, anti-AMPK, anti-phosphorylated AMPK (pAMPK, Thr172), anti-ACC, anti-phosphorylated ACC (pACC, Ser79), anti-LKB1, anti-phosphorylated LKB1 (pLKB1, Ser428), anti-PP2AA, anti-PP2AB, anti-PP2C?
Phosphorylation (phosphorylated) of pAMPK
14) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
This is consistent with our current finding of elevated phosphorylation of AMPK?
Phosphorylation (phosphorylation) of AMPK
15) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.39 Pain Relevance 0.08
Result from our current study revealed that acute ethanol treatment turned on LKB1 phosphorylation with a further increase in ADH mice, supporting a likely role of LKB1 in the ADH and ethanol-induced AMPK activation (shown by phosphorylation of AMPK and ACC).
Phosphorylation (phosphorylation) of AMPK
16) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.11 Pain Relevance 0.03
, anti-Glut4, anti-AMPK, anti-phosphorylated AMPK (pAMPK, Thr172), anti-ACC, anti-phosphorylated ACC (pACC, Ser79), anti-LKB1, anti-phosphorylated LKB1 (pLKB1, Ser428), anti-PP2AA, anti-PP2AB, anti-PP2C?
Phosphorylation (phosphorylated) of pAMPK
17) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
activity via phosphorylating threonine residue(s) of AMPK [46].
Phosphorylation (phosphorylating) of AMPK
18) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.15 Pain Relevance 0
mg/kg, i.p.) increased the phosphorylations of AMPK and ACC rapidly (15?
Phosphorylation (phosphorylations) of AMPK
19) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.28 Pain Relevance 0.05
agonists (i.e., TZDs) activate AMPK by phosphorylating AMPK independently of PPAR?
Phosphorylation (phosphorylating) of AMPK associated with agonist
20) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.15 Pain Relevance 0.05

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