INT15161

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Context Info
Confidence 0.50
First Reported 1984
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.30
Pain Relevance 7.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VIP)
Anatomy Link Frequency
colon 4
small intestine 4
ileum 3
jejunum 3
plasma 2
VIP (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 55 100.00 Very High Very High Very High
qutenza 48 100.00 Very High Very High Very High
Neuropeptide 240 99.16 Very High Very High Very High
medulla 2 98.28 Very High Very High Very High
vagus nerve 4 97.48 Very High Very High Very High
Neurotransmitter 31 97.28 Very High Very High Very High
Catecholamine 6 96.56 Very High Very High Very High
Pain 48 96.48 Very High Very High Very High
antagonist 5 94.32 High High
tetrodotoxin 3 93.76 High High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 5 100.00 Very High Very High Very High
Stress 13 99.98 Very High Very High Very High
Pain 48 96.48 Very High Very High Very High
Pathologic Processes 2 93.68 High High
Psoriasis 10 91.92 High High
Increased Venous Pressure Under Development 3 91.32 High High
Carcinoma 3 87.84 High High
Central Nervous System Disease 1 86.52 High High
INFLAMMATION 15 73.28 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 69.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ruthenium red selectively antagonizes capsaicin-induced release of vasoactive intestinal polypeptide (VIP) from the human colon.
Positive_regulation (capsaicin-induced) of Localization (release) of VIP in colon associated with qutenza
1) Confidence 0.50 Published 1991 Journal Neurosci. Lett. Section Title Doc Link 1717894 Disease Relevance 0.08 Pain Relevance 0.76
RR (10 microM) completely antagonized the capsaicin-induced release of VIP from muscle of human colon.
Positive_regulation (induced) of Localization (release) of VIP in muscle associated with qutenza
2) Confidence 0.47 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1717894 Disease Relevance 0.09 Pain Relevance 0.73
Multiple mechanisms leading to VIP release exist in the human colon.
Positive_regulation (leading) of Localization (release) of VIP in colon
3) Confidence 0.47 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1717894 Disease Relevance 0.07 Pain Relevance 0.69
Exposure to capsaicin (1 microM) produced a prompt and sustained release of vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) from mucosa-free strips of human small intestine (jejunum and ileum).
Positive_regulation (produced) of Localization (release) of VIP in jejunum associated with qutenza
4) Confidence 0.45 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2786168 Disease Relevance 0 Pain Relevance 0.46
These can go on over a prolonged period since (1) once released, VIP induces its own further secretion; (2) VIP induces release of interleukin-6 (IL6) that evokes both its own further release and release of VIP.
Positive_regulation (evokes) of Localization (release) of VIP
5) Confidence 0.43 Published 2009 Journal Med. Hypotheses Section Abstract Doc Link 18926642 Disease Relevance 1.13 Pain Relevance 0.49
It is concluded that the stimulation-induced increase in plasma VIP is due to release of VIP outside the brain.
Positive_regulation (due) of Localization (release) of VIP in plasma
6) Confidence 0.38 Published 1984 Journal Gen. Pharmacol. Section Abstract Doc Link 6335447 Disease Relevance 0.15 Pain Relevance 0.45
It is concluded that capsaicin excitation of primary afferents in the human ileum, leading to VIP release and muscle relaxation, occurs with mechanisms similar to those operating in animal tissues and that ruthenium red acts as a selective capsaicin antagonist in the human ileum.
Positive_regulation (leading) of Localization (release) of VIP in ileum associated with qutenza and antagonist
7) Confidence 0.32 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1716572 Disease Relevance 0 Pain Relevance 0.99
The vagus also acts indirectly by stimulating gastrin release from the antrum and vasoactive intestinal peptide (VIP) release from the small intestine.
Positive_regulation (stimulating) of Localization (release) of vasoactive intestinal peptide in small intestine
8) Confidence 0.27 Published 2011 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2929521 Disease Relevance 0.07 Pain Relevance 0.12
The vagus also acts indirectly by stimulating gastrin release from the antrum and vasoactive intestinal peptide (VIP) release from the small intestine.
Positive_regulation (stimulating) of Localization (release) of VIP in small intestine
9) Confidence 0.27 Published 2011 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2929521 Disease Relevance 0.07 Pain Relevance 0.12
Stress induces the secretion of enkephalins, catestatin, NPY, VIP, galanin, and other neuropeptides (23–26).
Positive_regulation (induces) of Localization (secretion) of VIP associated with stress, neuropeptide and enkephalin
10) Confidence 0.19 Published 2010 Journal AAPS J Section Body Doc Link PMC2976990 Disease Relevance 1.06 Pain Relevance 2.50
Exposure to capsaicin (1 microM) produced a prompt and sustained release of vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) from mucosa-free strips of human small intestine (jejunum and ileum).
Positive_regulation (produced) of in ileum Localization (release) of VIP in jejunum associated with qutenza
11) Confidence 0.15 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2786168 Disease Relevance 0 Pain Relevance 0.46
According to this hypothesis, both cholesterol and the examined compounds stimulated the beta-secretase cleavage of APP, resulting in a massive increase of secreted amyloid-beta peptides.
Positive_regulation (increase) of Localization (secreted) of peptides in cleavage associated with alzheimer's dementia
12) Confidence 0.11 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17395689 Disease Relevance 0.57 Pain Relevance 0.11

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