INT15166

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1983
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 40
Total Number 44
Disease Relevance 13.01
Pain Relevance 16.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
neutrophils 4
lung 3
caudate putamen 2
fat 2
macrophage 1
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 53 100.00 Very High Very High Very High
Hippocampus 7 100.00 Very High Very High Very High
antinociception 6 100.00 Very High Very High Very High
withdrawal 1 100.00 Very High Very High Very High
Morphine 41 99.98 Very High Very High Very High
Calcitonin gene-related peptide 34 99.64 Very High Very High Very High
Nucleus accumbens 4 99.48 Very High Very High Very High
Opioid 11 99.24 Very High Very High Very High
Analgesic 8 99.14 Very High Very High Very High
narcan 21 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pheochromocytoma 27 100.00 Very High Very High Very High
Hyperglycemia 12 99.98 Very High Very High Very High
Arthritis 9 99.84 Very High Very High Very High
Hyperlipidemia 8 99.62 Very High Very High Very High
Neurogenic Inflammation 7 98.84 Very High Very High Very High
Increased Venous Pressure Under Development 11 98.70 Very High Very High Very High
Obesity 152 98.68 Very High Very High Very High
Appetite Loss 1 98.24 Very High Very High Very High
Adhesions 3 98.20 Very High Very High Very High
Bronchial Hyperreactivity 2 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that enkephalinase A activation in rats given ethanol is determined by a direct action of ethanol on the enzyme.
Positive_regulation (activation) of enkephalinase
1) Confidence 0.70 Published 1984 Journal Biull Eksp Biol Med Section Abstract Doc Link 6378268 Disease Relevance 0 Pain Relevance 0.20
In the present study, chronic treatment with haloperidol (1 mg/kg/day, 12 days) increased NEP activity in nucleus accumbens, and chronic treatment with chlorpromazine (4 mg/kg/day, 12 days) increased NEP activity in caudate putamen.
Positive_regulation (increased) of NEP in caudate putamen associated with nucleus accumbens
2) Confidence 0.69 Published 1993 Journal Peptides Section Abstract Doc Link 7904340 Disease Relevance 0 Pain Relevance 0.30
NEP and APN activity on neutrophils from all pheochromocytoma patients was significantly increased as compared with healthy controls, non-functional adenomas and malignant renal tumors.
Positive_regulation (increased) of NEP in neutrophils associated with adenoma, malignant neoplastic disease, renal cancer and pheochromocytoma
3) Confidence 0.64 Published 2003 Journal Oncol. Rep. Section Abstract Doc Link 12469178 Disease Relevance 1.61 Pain Relevance 0.38
Also, LPS caused significant increases in NEP mRNA, SP and CGRP levels, airway reactivity to capsaicin and SP, and neutrophil counts, but a significant decrease in macrophage count.
Positive_regulation (increases) of NEP mRNA in macrophage associated with qutenza and calcitonin gene-related peptide
4) Confidence 0.64 Published 2003 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 12738685 Disease Relevance 0.09 Pain Relevance 0.32
In the present study, chronic treatment with haloperidol (1 mg/kg/day, 12 days) increased NEP activity in nucleus accumbens, and chronic treatment with chlorpromazine (4 mg/kg/day, 12 days) increased NEP activity in caudate putamen.
Positive_regulation (increased) of NEP in caudate putamen associated with nucleus accumbens
5) Confidence 0.61 Published 1993 Journal Peptides Section Abstract Doc Link 7904340 Disease Relevance 0 Pain Relevance 0.30
NEP staining in the transplants consistently appeared before NEP staining in the surrounding host striatum supporting a relative increase in NEP activity in the transplants.
Positive_regulation (increase) of NEP in striatum
6) Confidence 0.60 Published 1993 Journal Brain Res. Section Abstract Doc Link 8330216 Disease Relevance 0.08 Pain Relevance 0.16
Morphine preconditioning increases NEP activities to attenuate shedding of gp100MEL14 and to ICAM-1 and, thus, provides myocardial protection.
Positive_regulation (increases) of NEP associated with morphine
7) Confidence 0.60 Published 1998 Journal Cardiovasc. Res. Section Abstract Doc Link 10070497 Disease Relevance 0.07 Pain Relevance 0.89
Although preliminary, this study has shown specifically and consistently up-regulated NEP activity on neutrophils from pheochromocytoma patients, and uniformly decreased NEP activity in these patients after adrenalectomy.
Positive_regulation (up-regulated) of NEP in neutrophils associated with pheochromocytoma
8) Confidence 0.56 Published 2003 Journal Oncol. Rep. Section Abstract Doc Link 12469178 Disease Relevance 1.22 Pain Relevance 0.20
DE exposure consistently inactivated tissue NEP, a key factor that switches neurogenic inflammation from its physiological and protective functions to a role that increases and perpetuates lung injury.
Positive_regulation (inactivated) of NEP in lung associated with lung injury, inflammation and neurogenic inflammation
9) Confidence 0.56 Published 2005 Journal Res Rep Health Eff Inst Section Abstract Doc Link 15916011 Disease Relevance 0.74 Pain Relevance 0.62
Our data support that LPS-induced bronchial hyperreactivity to capsaicin is related closely to the upregulation of tachykinin gene expression, but not the upregulation of NEP.
Positive_regulation (upregulation) of NEP associated with bronchial hyperreactivity and qutenza
10) Confidence 0.56 Published 2003 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 12738685 Disease Relevance 0.10 Pain Relevance 0.31
At the light microscopic level, both techniques revealed a heterogeneous distribution of immunoreactive enkephalinase in the caudoputamen, characterized by the presence of patches of intense immunolabeling prominent against a relatively strong immunoreactive matrix, a pattern reminiscent of mu opioid receptors radioautographically labeled in the same region.
Positive_regulation (distribution) of enkephalinase associated with mu opioid receptor
11) Confidence 0.50 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2201754 Disease Relevance 0 Pain Relevance 0.05
Significant, age-dependent increase in thermonociceptive thresholds and higher levels of enkephalinase A in structures of the endogenous antinociceptive system were observed in the offspring compared with the control.
Positive_regulation (levels) of enkephalinase associated with antinociceptive
12) Confidence 0.50 Published 2000 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 10977956 Disease Relevance 0 Pain Relevance 0.56
The analgesic effects of morphine, but not those of the enkephalinase inhibitor thiorphan, are enhanced in arthritic rats.
Positive_regulation (enhanced) of enkephalinase associated with analgesic, narcan, arthritis and morphine
13) Confidence 0.50 Published 1983 Journal Brain Res. Section Title Doc Link 6574799 Disease Relevance 0.61 Pain Relevance 0.67
Its functions in the gastrointestinal (GI) tract are less well understood although enkephalinase inhibitors were reported to induce a constellation of antisecretory and motor responses.
Positive_regulation (induce) of enkephalinase
14) Confidence 0.50 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1716743 Disease Relevance 0 Pain Relevance 0.10
Fifteen minute exposures to a specific magnetic field both increased enkephalinase inhibitor induced opioid analgesia and induced analgesia in untreated snails.
Positive_regulation (increased) of enkephalinase associated with opioid and analgesia
15) Confidence 0.49 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9111740 Disease Relevance 0 Pain Relevance 0.93
We conclude that enkephalinase inhibitors like thiorphan and acetorphan increase daily food intake in sheep probably by increasing enkephalin levels in peripheral tissues.
Spec (probably) Positive_regulation (increase) of enkephalinase associated with enkephalin
16) Confidence 0.49 Published 1987 Journal Life Sci. Section Abstract Doc Link 3298911 Disease Relevance 0.10 Pain Relevance 0.10
SSCS also significantly inactivated pulmonary neutral endopeptidase (NEP) in lung tissue.
Positive_regulation (inactivated) of NEP in lung
17) Confidence 0.49 Published 2004 Journal Toxicology Section Abstract Doc Link 15297018 Disease Relevance 0.39 Pain Relevance 1.10
The enzyme activities in the regionally separated tissues were 54-191 pmol/min.mg protein for enkephalinase A and 79-153 pmol/min.mg protein for enkephalinase B, which were calculated from the formation of Tyr-Gly-Gly and Tyr-Gly, respectively, during the enzyme reaction.
Positive_regulation (calculated) of enkephalinase B
18) Confidence 0.47 Published 1988 Journal J. Chromatogr. Section Abstract Doc Link 3235505 Disease Relevance 0 Pain Relevance 0.23
In contrast, enkephalinase activity decreased in the soluble fraction of the hippocampus but increased in the membrane fraction.
Positive_regulation (increased) of enkephalinase in hippocampus associated with hippocampus
19) Confidence 0.45 Published 2009 Journal Neuropsychobiology Section Abstract Doc Link 19468242 Disease Relevance 0.45 Pain Relevance 0.39
Owing to the remarkable similarity in the general topology of metallopeptidases, the differences in optimal binding requirements to enkephalinase and angiotensin-converting enzyme were interpreted from crystallographic studies on related enzymes such as thermolysin and carboxypeptidase A.
Positive_regulation (requirements) of enkephalinase
20) Confidence 0.43 Published 1984 Journal Eur. J. Biochem. Section Abstract Doc Link 6321177 Disease Relevance 0 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox