INT151662

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.55
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gsk3a) kinase activity (Gsk3a)
Anatomy Link Frequency
epidermis 1
Gsk3a (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 4 98.72 Very High Very High Very High
tricyclic antidepressant 1 82.72 Quite High
fluoxetine 1 80.80 Quite High
Desipramine 1 80.32 Quite High
addiction 2 67.68 Quite High
depression 1 54.80 Quite High
tolerance 18 5.00 Very Low Very Low Very Low
Kinase C 16 5.00 Very Low Very Low Very Low
antagonist 15 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 2 90.40 High High
Bullous Skin Disease 304 89.32 High High
Cancer 4 72.40 Quite High
Disease 24 72.00 Quite High
Adhesions 51 66.32 Quite High
Starvation 1 44.68 Quite Low
Autoimmune Disease 4 40.96 Quite Low
Carcinoma 1 29.28 Quite Low
Skin Cancer 1 27.76 Quite Low
Breast Cancer 1 23.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No effect of selective inhibitors of p38-MAPK, phosphatidylinositol 3-kinase (PI3-K)/Akt, and glycogen synthase kinase (GSK-3) on the imipramine-induced inhibition of GR function was detected.
Negative_regulation (inhibitors) of glycogen synthase kinase
1) Confidence 0.15 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.07 Pain Relevance 0.34
According to this concept, in healthy epidermis Dsg 3 binding results in inhibition of glycogen synthase kinase 3 (GSK3) via activation of phosphatidylinositol trisphosphate kinase (PI3K) and Akt.
Negative_regulation (inhibition) of glycogen synthase kinase 3 in epidermis
2) Confidence 0.06 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.30 Pain Relevance 0.03
Whereas on the other hand, it diminished phospho protein kinase B (pAKT) and phospho-glycogen synthase kinase (pGSK) levels in both cell lines and upregulated gluconeogenesis in H4-II-E-cells by attenuating the effect of insulin on the expression on PEPCK [73].
Negative_regulation (diminished) of phospho-glycogen synthase kinase
3) Confidence 0.02 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.18 Pain Relevance 0

General Comments

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