INT151663

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.03
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gsk3a) kinase activity (Gsk3a)
Gsk3a (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 1 99.92 Very High Very High Very High
antidepressant 4 99.52 Very High Very High Very High
tricyclic antidepressant 1 82.72 Quite High
fluoxetine 1 81.60 Quite High
Desipramine 1 81.12 Quite High
Calcium channel 14 77.72 Quite High
sodium channel 6 75.84 Quite High
gABA 12 69.12 Quite High
GABAergic 8 66.12 Quite High
depression 1 54.80 Quite High
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 12 95.12 Very High Very High Very High
Disease 40 91.16 High High
Alzheimer's Dementia 5 87.44 High High
Injury 3 85.28 High High
Cancer 2 73.20 Quite High
Convulsion 9 60.68 Quite High
Amyloid Plaque 4 56.24 Quite High
Epilepsy 24 52.64 Quite High
Neuropathic Pain 13 47.60 Quite Low
Headache 5 46.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No effect of selective inhibitors of p38-MAPK, phosphatidylinositol 3-kinase (PI3-K)/Akt, and glycogen synthase kinase (GSK-3) on the imipramine-induced inhibition of GR function was detected.
Neg (No) Regulation (effect) of glycogen synthase kinase
1) Confidence 0.16 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.07 Pain Relevance 0.34
is thought to catalyze the formation of NFTs [84,92,93], affecting tau proteins through regulation of glycogen synthase kinase-3 (GSK3) activity [94,95] and activation of cyclin-dependent kinase 5 (CDK5) [96].
Regulation (regulation) of glycogen synthase kinase-3
2) Confidence 0.03 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.66 Pain Relevance 0
Intracellular targets include modulation of inositol metabolism, kinases as ERK and MARCK, glycogen synthase-3, protein kinase C, and early inducible genes (Göttlicher et al. 2001; Phiel et al. 2001; Löscher, 2002a, b; Johannessen and Johannessen, 2003; Harwood and Agam, 2003; Ju and Greenberg, 2003; Brunello and Tascedda, 2003; Anmann and Grünze, 2005).
Regulation (modulation) of glycogen synthase-3 associated with kinase c
3) Confidence 0.02 Published 2008 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2746576 Disease Relevance 0.30 Pain Relevance 0.19

General Comments

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