INT151684

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Context Info
Confidence 0.54
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 16
Disease Relevance 6.25
Pain Relevance 3.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MCF2L) plasma membrane (MCF2L) cytoplasm (MCF2L)
Anatomy Link Frequency
brain 2
nucleus 1
MCF2L (Homo sapiens)
Pain Link Frequency Relevance Heat
deep brain stimulation 696 100.00 Very High Very High Very High
Thalamus 322 99.06 Very High Very High Very High
vagus nerve 28 98.60 Very High Very High Very High
Thalamotomy 10 96.36 Very High Very High Very High
cva 11 92.00 High High
Action potential 62 90.84 High High
palliative 20 85.76 High High
midbrain 18 83.52 Quite High
Cluster headache 2 83.28 Quite High
Transcranial magnetic stimulation 97 82.16 Quite High
Disease Link Frequency Relevance Heat
Movement Disorders 5 100.00 Very High Very High Very High
Parkinson's Disease 263 99.48 Very High Very High Very High
Tremor 108 99.44 Very High Very High Very High
Disease 741 99.36 Very High Very High Very High
Epilepsy 40 98.76 Very High Very High Very High
Dystonia 3 97.52 Very High Very High Very High
Cognitive Disorder 55 97.48 Very High Very High Very High
Hypokinesia 54 95.48 Very High Very High Very High
Postoperative Hemorrhage 1 92.00 High High
Convulsion 41 89.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: Deep brain stimulation (DBS) has become a standard procedure for movement disorders such as Parkinson's disease, essential tremor or dystonia.
Gene_expression (procedure) of DBS in brain associated with tremor, movement disorders, deep brain stimulation, dystonia and disease
1) Confidence 0.54 Published 2008 Journal Zentralbl. Neurochir. Section Abstract Doc Link 18444218 Disease Relevance 0.47 Pain Relevance 0.29
Since its successful application for tremor by Benabid et al. in 1987, DBS is applied on a large scale for movement disorders such as Parkinson's disease, tremor, and dystonia.
Gene_expression (applied) of DBS associated with movement disorders, tremor, deep brain stimulation, dystonia and disease
2) Confidence 0.28 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2844529 Disease Relevance 1.13 Pain Relevance 0.21
Of this loop the subthalamic nucleus, the globus pallidus internus and several parts of the thalamus (most commonly the VIM nucleus) are currently targeted by DBS.


Gene_expression (targeted) of DBS in nucleus associated with deep brain stimulation and thalamus
3) Confidence 0.28 Published 2008 Journal Frontiers in Neuroscience Section Body Doc Link PMC2570064 Disease Relevance 0 Pain Relevance 0.37
With respect to the latter, DBS produces effects over a matter of milliseconds, in tune with the electrophysiology of the brain.
Gene_expression (produces) of DBS in brain associated with deep brain stimulation
4) Confidence 0.28 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671781 Disease Relevance 0.22 Pain Relevance 0.26
One could similarly record the average GPi output from a DBS electrode in GPi and reconstruct the estimated TC-cell activity.
Gene_expression (electrode) of DBS associated with deep brain stimulation
5) Confidence 0.22 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.07 Pain Relevance 0.05
For several years, it was therefore assumed that stimulation at the DBS frequencies being used (typically 130?
Gene_expression (frequencies) of DBS associated with deep brain stimulation
6) Confidence 0.22 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.37 Pain Relevance 0.17
A simpler way to infer such correlation in practice would be to estimate spectral concentration in GPi local field potentials, and this is directly observable from an ordinary DBS electrode placed within the GPi.
Gene_expression (electrode) of DBS associated with deep brain stimulation
7) Confidence 0.22 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.07 Pain Relevance 0.17
A nearly identical experience has been reported in the placement of DBS electrodes in small thalamic targets for epileptic seizure suppression (Hodaie et al. 2002).
Gene_expression (electrodes) of DBS associated with epilepsy and deep brain stimulation
8) Confidence 0.22 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.53 Pain Relevance 0.25
DBS appeared to be effective when used bilaterally, without the symmetrical lesion complications.
Neg (without) Gene_expression (effective) of DBS associated with deep brain stimulation
9) Confidence 0.22 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.94 Pain Relevance 0.29
The figure shows that such constant DBS does not appear capable of achieving the reliability possible with feedback control.13
Neg (not) Gene_expression (capable) of DBS associated with deep brain stimulation
10) Confidence 0.22 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.18 Pain Relevance 0.13
Their results demonstrate that the error index (described above) is higher for the MPTP monkeys without DBS or with subtherapeutic DBS, and consistently lowest for normal monkeys and those MPTP monkeys with therapeutic levels of DBS.
Gene_expression (levels) of DBS associated with parkinson's disease and deep brain stimulation
11) Confidence 0.22 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.37 Pain Relevance 0.33
Although the STN is now the dominant DBS target, it is unclear whether the GPi, with a less burdensome set of cognitive side effects, might be better for some patients (Anderson et al. 2005).
Gene_expression (target) of DBS associated with cognitive disorder and deep brain stimulation
12) Confidence 0.22 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.82 Pain Relevance 0.37
Increasing the synaptic current from the GPi, sGi, as the DBS parameter in equation (8.7) literally adds the IGi?
Gene_expression (adds) of DBS associated with deep brain stimulation
13) Confidence 0.22 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.05 Pain Relevance 0.17
Amazingly, we observe that in the course of placing DBS electrodes in ParkinsonÂ’s disease patients, there is an immediate clinical improvement in about half of patients at the conclusion of electrode placement, before the electrode is connected to the stimulator (Tasker 1998).
Gene_expression (electrodes) of DBS associated with deep brain stimulation and disease
14) Confidence 0.22 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.50 Pain Relevance 0.20
VNS and DBS stimulation parameters are wirelessly programmed approximately 2?
Gene_expression (programmed) of DBS associated with deep brain stimulation
15) Confidence 0.20 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2901135 Disease Relevance 0.06 Pain Relevance 0.24
Hence, despite its invasive nature, DBS is heavily researched due to its promise of rapidly modulating dysfunctional network activity to desired states in a dose-dependent manner only when it is needed.
Gene_expression (researched) of DBS associated with deep brain stimulation
16) Confidence 0.20 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2901135 Disease Relevance 0.47 Pain Relevance 0.25

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