INT151689

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Context Info
Confidence 0.08
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.31
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CADM1) cell adhesion (CADM1) plasma membrane (CADM1)
Anatomy Link Frequency
lipid droplets 2
polymorphonuclear leukocytes 2
CADM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 99.16 Very High Very High Very High
Inflammation 59 98.76 Very High Very High Very High
rheumatoid arthritis 28 91.44 High High
cINOD 5 90.48 High High
metalloproteinase 3 76.48 Quite High
abatacept 1 39.68 Quite Low
cOX1 1 25.00 Low Low
COX2 1 25.00 Low Low
methotrexate 28 20.00 Low Low
Adalimumab 1 16.84 Low Low
Disease Link Frequency Relevance Heat
Adhesions 13 100.00 Very High Very High Very High
Breast Cancer 53 99.20 Very High Very High Very High
INFLAMMATION 60 98.76 Very High Very High Very High
Hypergammaglobulinemia 1 96.20 Very High Very High Very High
Cancer 30 95.84 Very High Very High Very High
Rheumatoid Arthritis 28 91.44 High High
Targeted Disruption 1 89.68 High High
Hematological Disease 2 89.60 High High
Rhinitis 43 88.48 High High
Peritonitis 1 83.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It attenuated the expressions of ethanol-induced pro-inflammatory cytokines, including interleukin (IL)-1beta and interferon-gamma, a weak activation of IL-10, the inhibition of the alcohol-induced overexpression of intercellular adhesion molecule-1, and the considerable induction of heat shock protein-72 expression in gastric mucosal homogenates.
Positive_regulation (induced) of Gene_expression (overexpression) of adhesion molecule-1
1) Confidence 0.08 Published 2008 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 18444990 Disease Relevance 0.06 Pain Relevance 0
Moreover, 11a treatment attenuated expression of macrophage adhesion molecule-1 (Mac-1) on extravasated polymorphonuclear leukocytes (PMNs) which indicates that the activation was reduced.
Positive_regulation (attenuated) of Gene_expression (expression) of macrophage adhesion molecule-1 in polymorphonuclear leukocytes associated with adhesions
2) Confidence 0.08 Published 2009 Journal Bioorg. Med. Chem. Section Abstract Doc Link 19097798 Disease Relevance 0.88 Pain Relevance 0.40
It attenuated the expressions of ethanol-induced pro-inflammatory cytokines, including interleukin (IL)-1beta and interferon-gamma, a weak activation of IL-10, the inhibition of the alcohol-induced overexpression of intercellular adhesion molecule-1, and the considerable induction of heat shock protein-72 expression in gastric mucosal homogenates.
Positive_regulation (overexpression) of Gene_expression (overexpression) of adhesion molecule-1
3) Confidence 0.05 Published 2008 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 18444990 Disease Relevance 0.06 Pain Relevance 0
Genistein treatment of human breast cancer cell lines has similarly been found to induce the expression of a number of maturation markers, including casein, lipid droplets and intercellular adhesion molecule-1 [43].
Positive_regulation (induce) of Gene_expression (expression) of adhesion molecule-1 in lipid droplets associated with breast cancer and adhesions
4) Confidence 0.03 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 1.16 Pain Relevance 0
Additionally, via enhanced expression of intercellular adhesion molecule-1, IL-6 promotes the infiltration of inflammatory cells into synovial tissue, and acting synergistically with TNF-?
Positive_regulation (enhanced) of Gene_expression (expression) of adhesion molecule-1 associated with inflammation and adhesions
5) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.99 Pain Relevance 0.33
also increases the expression of cell adhesion molecules (intercellular adhesion molecule 1 [ICAM-1] and vascular cell adhesion molecule 1 [VCAM-1]).19 Proinflammatory interleukins (IL-1?
Positive_regulation (increases) of Gene_expression (expression) of adhesion molecule 1 associated with adhesions
6) Confidence 0.01 Published 2010 Journal International Journal of General Medicine Section Body Doc Link PMC2866558 Disease Relevance 1.15 Pain Relevance 0.28

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