INT15171

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Context Info
Confidence 0.49
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.13
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
neutrophils 6
Itgam (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 2 99.72 Very High Very High Very High
midbrain 12 96.44 Very High Very High Very High
Inflammatory response 2 90.72 High High
Enkephalin 1 81.44 Quite High
Inflammation 116 76.64 Quite High
Inflammatory mediators 6 70.96 Quite High
dopaminergic neurodegeneration 1 48.08 Quite Low
chemokine 16 31.36 Quite Low
cytokine 20 22.56 Low Low
cINOD 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 4 100.00 Very High Very High Very High
Parkinson's Disease 108 99.96 Very High Very High Very High
INFLAMMATION 95 90.32 High High
Pneumonia 34 77.44 Quite High
Leukemia 1 69.92 Quite High
Toxicity 15 49.60 Quite Low
Disease 37 5.00 Very Low Very Low Very Low
Injury 22 5.00 Very Low Very Low Very Low
Aging 18 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Herein we show that f-MLP and substance P induce rapid changes in neutrophil morphology, migration, and adhesion molecule expression, including upregulation of Mo1 (CD11b/CD18) and shedding of LAM-1 (also known as LECAM-1, Leu8, or TQ-1, the human homologue of murine gp100MEL14).
Positive_regulation (changes) of Positive_regulation (upregulation) of CD11b/CD18 in neutrophil associated with adhesions and substance p
1) Confidence 0.49 Published 1991 Journal Blood Section Abstract Doc Link 1717072 Disease Relevance 0.41 Pain Relevance 0.29
As previously observed, a sharp increase of Mac-1 and PHOX followed MPTP treatment, as early as 1 dpt, in mice fed with the control diet, with levels remaining high at both 3 and 7 dpt (Figure 7A, B).
Positive_regulation (followed) of Positive_regulation (increase) of Mac-1 associated with parkinson's disease
2) Confidence 0.40 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.46 Pain Relevance 0.28
LPS induced a significant activation of lung-marginated neutrophils, promoting shedding of L-selectin (i.e. reduced expression), and upregulation of CD11b.
Positive_regulation (promoting) of Positive_regulation (upregulation) of CD11b in neutrophils
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.13 Pain Relevance 0.04
LPS induced a significant activation of lung-marginated neutrophils, promoting shedding of L-selectin (i.e. reduced expression), and upregulation of CD11b.
Positive_regulation (induced) of Positive_regulation (upregulation) of CD11b in neutrophils
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.13 Pain Relevance 0.04

General Comments

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