INT151718

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.63
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges) nucleus (Ptges) cytoplasm (Ptges)
Anatomy Link Frequency
macrophages 1
Ptges (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3 99.30 Very High Very High Very High
cINOD 4 96.40 Very High Very High Very High
COX-2 inhibitor 2 94.36 High High
Pain 1 36.36 Quite Low
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 2 99.80 Very High Very High Very High
INFLAMMATION 7 99.30 Very High Very High Very High
Intestinal Cancer 4 97.16 Very High Very High Very High
Aberrant Crypt Foci 6 94.60 High High
Colon Cancer 6 90.92 High High
Adenoma 4 82.28 Quite High
Disease 1 53.00 Quite High
Pain 1 36.36 Quite Low
Fever 1 36.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we evaluated the chemopreventive efficacy of targeting the terminal synthase microsomal PGE(2) synthase 1 (mPGES-1), which is responsible for generating PGE(2), in two murine models of intestinal cancer.
Regulation (targeting) of mPGES-1 associated with intestinal cancer
1) Confidence 0.27 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18451151 Disease Relevance 0.58 Pain Relevance 0.09
Our data show the feasibility of targeting mPGES-1 for cancer chemoprevention with the potential for improved tolerability over traditional nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors.
Regulation (targeting) of mPGES-1 associated with inflammation, cancer, cinod and cox-2 inhibitor
2) Confidence 0.12 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18451151 Disease Relevance 0.85 Pain Relevance 0.14
Our findings point out to Egr-1 and NF-kappaB cooperation as determinant for PGE2 synthesis by macrophages in inflammatory processes through the coordinated regulation of COX-2 and mPGES-1.
Regulation (regulation) of mPGES-1 in macrophages associated with inflammation
3) Confidence 0.07 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.20 Pain Relevance 0.08

General Comments

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