INT151719

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.90
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
colon 2
Ctnnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 4 80.08 Quite High
COX-2 inhibitor 2 76.00 Quite High
Disease Link Frequency Relevance Heat
Aberrant Crypt Foci 6 99.84 Very High Very High Very High
Adenoma 4 97.84 Very High Very High Very High
Intestinal Cancer 4 95.72 Very High Very High Very High
Colon Cancer 6 94.72 High High
Cancer 2 86.88 High High
INFLAMMATION 4 68.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, mPGES-1 deletion also blocked the nuclear accumulation of beta-catenin in ACF, confirming that beta-catenin is a critical target of PGE(2) procarcinogenic signaling in the colon.
Negative_regulation (blocked) of Positive_regulation (accumulation) of beta-catenin in colon associated with aberrant crypt foci
1) Confidence 0.23 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18451151 Disease Relevance 0.96 Pain Relevance 0.17
This effect occurred despite loss of Apc heterozygosity and beta-catenin activation.
Negative_regulation (loss) of Positive_regulation (activation) of beta-catenin
2) Confidence 0.23 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18451151 Disease Relevance 0.94 Pain Relevance 0.07

General Comments

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