INT15172

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 45
Total Number 46
Disease Relevance 23.54
Pain Relevance 10.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
neutrophils 8
microglia 5
myeloid cells 2
lymphocytes 2
bone marrow 1
Itgam (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 6 100.00 Very High Very High Very High
Inflammation 682 99.84 Very High Very High Very High
Arthritis 107 99.84 Very High Very High Very High
Morphine 26 99.82 Very High Very High Very High
agonist 33 99.40 Very High Very High Very High
analgesia 3 99.04 Very High Very High Very High
tolerance 14 98.60 Very High Very High Very High
substance P 2 97.94 Very High Very High Very High
Central nervous system 106 97.92 Very High Very High Very High
cytokine 445 97.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 800 99.84 Very High Very High Very High
Arthritis 130 99.84 Very High Very High Very High
Stroke 204 99.72 Very High Very High Very High
Hypothermia 110 99.70 Very High Very High Very High
Adhesions 105 99.36 Very High Very High Very High
Parkinson's Disease 226 99.24 Very High Very High Very High
Body Weight 8 99.06 Very High Very High Very High
Retroviridae Infections 6 98.34 Very High Very High Very High
Disease 493 97.66 Very High Very High Very High
Targeted Disruption 139 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Herein we show that f-MLP and substance P induce rapid changes in neutrophil morphology, migration, and adhesion molecule expression, including upregulation of Mo1 (CD11b/CD18) and shedding of LAM-1 (also known as LECAM-1, Leu8, or TQ-1, the human homologue of murine gp100MEL14).
Positive_regulation (upregulation) of CD11b/CD18 in neutrophil associated with adhesions and substance p
1) Confidence 0.67 Published 1991 Journal Blood Section Abstract Doc Link 1717072 Disease Relevance 0.40 Pain Relevance 0.28
It also effectively blocks the upregulation of Mac-1 (CD11b/CD18) on neutrophils.
Positive_regulation (upregulation) of CD11b/CD18 in neutrophils
2) Confidence 0.67 Published 1996 Journal Eur. J. Immunol. Section Abstract Doc Link 8566054 Disease Relevance 0.82 Pain Relevance 0.41
There was no upregulation of Mac-1 (CD11b/ CD18) or shedding of L-selectin on circulating neutrophils.
Neg (no) Positive_regulation (upregulation) of Mac-1 in neutrophils
3) Confidence 0.64 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10774834 Disease Relevance 0.98 Pain Relevance 0.73
It also effectively blocks the upregulation of Mac-1 (CD11b/CD18) on neutrophils.
Positive_regulation (upregulation) of Mac-1 in neutrophils
4) Confidence 0.58 Published 1996 Journal Eur. J. Immunol. Section Abstract Doc Link 8566054 Disease Relevance 0.82 Pain Relevance 0.38
As previously observed, a sharp increase of Mac-1 and PHOX followed MPTP treatment, as early as 1 dpt, in mice fed with the control diet, with levels remaining high at both 3 and 7 dpt (Figure 7A, B).
Positive_regulation (increase) of Mac-1 associated with parkinson's disease
5) Confidence 0.55 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.46 Pain Relevance 0.27
Moreover, TNF influences the trafficking of osteoclast precursors within the body, allowing an accumulation of Cd11b-positive monocytes within lymphoid organs, such as the spleen, which then can home to the inflammatory sites [9].


Positive_regulation (accumulation) of Cd11b in monocytes associated with inflammation
6) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 0.90 Pain Relevance 0.37
CD11b+/Gr1+ cell population in CIA mouse knee joint was also reduced significantly by EA at ST36, indicating that EA at ST36 reduced inflammatory granulocytes in CIA mouse knee joints (Data not shown).
Positive_regulation (population) of CD11b in granulocytes associated with inflammation, acupuncture and arthritis
7) Confidence 0.49 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810363 Disease Relevance 1.91 Pain Relevance 0.99
Western blot analysis of CD11b/c and GFAP protein demonstrated that minocycline and pentoxifylline, at doses delaying development of tolerance to morphine analgesia, significantly diminished the morphine-induced increase in CD11b/c protein level.
Positive_regulation (increase) of CD11b associated with tolerance, analgesia and morphine
8) Confidence 0.49 Published 2009 Journal Brain Behav. Immun. Section Abstract Doc Link 18684397 Disease Relevance 0.84 Pain Relevance 2.03
Furthermore, it appears that the interaction between phagocytes and surface P1/P2 epitope is via the Mac-1 (CD11b/CD18) integrin, which is upregulated on inflammatory cells recruited to the site of the implant [21,22].
Positive_regulation (upregulated) of CD11b/CD18 in phagocytes associated with inflammation
9) Confidence 0.45 Published 2007 Journal J Transl Med Section Body Doc Link PMC1929055 Disease Relevance 0.48 Pain Relevance 0.19
The clearance of HS oligosaccharides after treatment was associated with the absence of expression of disease markers and the very low, though often still detectable expression of some inflammation markers, including slightly increased CD11b signals and IL1ß mRNA amounts.
Positive_regulation (increased) of CD11b associated with inflammation and disease
10) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.56 Pain Relevance 0.09
There was no upregulation of Mac-1 (CD11b/ CD18) or shedding of L-selectin on circulating neutrophils.
Neg (no) Positive_regulation (upregulation) of CD11b in neutrophils
11) Confidence 0.43 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10774834 Disease Relevance 0.98 Pain Relevance 0.73
The CD11a(lo) population of splenocytes from the tick-infested mice was positive for TER-119 but negative for CD3, B220, CD11b and Gr, confirming that the splenocytes were members of the erythroid lineage.
Positive_regulation (negative) of CD11b
12) Confidence 0.41 Published 2005 Journal Ann Trop Med Parasitol Section Abstract Doc Link 16004711 Disease Relevance 0.33 Pain Relevance 0
LPS induced a significant activation of lung-marginated neutrophils, promoting shedding of L-selectin (i.e. reduced expression), and upregulation of CD11b.
Positive_regulation (upregulation) of CD11b in neutrophils
13) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.08 Pain Relevance 0.04
This discrepancy, however, may be due to use of CD11b as a marker for activated microglia because microglia at distinct activation states differentially express several activation markers [9,19].
Positive_regulation (use) of CD11b in microglia
14) Confidence 0.36 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 0.92 Pain Relevance 0
Murine retrovirus infection provoked an increase in body weight due to enlargement of lymphoid organs, and an increase in the percentage and absolute number of CD4+ and Mac 1+ cells.
Positive_regulation (increase) of Mac 1 in body associated with body weight and retroviridae infections
15) Confidence 0.32 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8253541 Disease Relevance 0.85 Pain Relevance 0.59
These results suggest that increased CD11b and MIP1?
Positive_regulation (increased) of CD11b
16) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.07 Pain Relevance 0
CD11b staining was dramatically increased in the brain of MPSIIIB mice at 3 months, compared to age-matched wild type mice (figure 4A).
Positive_regulation (increased) of CD11b in brain
17) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.23 Pain Relevance 0.08
Increased CD11b staining and MIP1?
Positive_regulation (Increased) of CD11b
18) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0 Pain Relevance 0
In 10-days-old MPSIIIB mice, we observed increased CD11b staining and normal GFAP staining, suggesting that MIP1?
Positive_regulation (increased) of CD11b
19) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.12 Pain Relevance 0
Flow cytometric analysis of perfused cortex from chimeric mice allowed to survive 24 hours after pMCAO showed a substantial increase in CD11b+CD45high cell population compared to unmanipulated control chimeras (Figure 2A).
Positive_regulation (increase) of CD11b in cortex
20) Confidence 0.29 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.07 Pain Relevance 0

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