INT151720

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.15
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Apc) plasma membrane (Apc) nucleus (Apc)
protein complex assembly (Apc) cytoplasm (Apc)
Anatomy Link Frequency
myocardium 2
Apc (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 2 94.64 High High
opioid receptor 1 90.56 High High
Enkephalin 1 85.72 High High
isoflurane 2 73.60 Quite High
cINOD 2 69.16 Quite High
COX-2 inhibitor 4 67.40 Quite High
Angina 3 47.56 Quite Low
agonist 1 18.72 Low Low
ischemia 25 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 240 100.00 Very High Very High Very High
Adenoma 60 97.84 Very High Very High Very High
Intestinal Cancer 2 95.72 Very High Very High Very High
Colon Cancer 36 82.56 Quite High
Aging 19 81.44 Quite High
Shock 1 77.12 Quite High
Aberrant Crypt Foci 3 75.20 Quite High
INFLAMMATION 3 68.92 Quite High
Cancer 67 66.20 Quite High
Infarction 2 48.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin destruction; loss of APC function increases transcription of ?
Negative_regulation (loss) of Positive_regulation (increases) of APC associated with familial adenomatous polyposis
1) Confidence 0.37 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.06 Pain Relevance 0
This effect occurred despite loss of Apc heterozygosity and beta-catenin activation.
Negative_regulation (loss) of Positive_regulation (activation) of Apc
2) Confidence 0.25 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18451151 Disease Relevance 0.94 Pain Relevance 0.07
The increase in ROS due to APC is impaired in the aged myocardium, even though the baseline ROS level is high in the aged myocardium [49].
Negative_regulation (impaired) of Positive_regulation (increase) of APC in myocardium
3) Confidence 0.04 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872846 Disease Relevance 0.16 Pain Relevance 0.39

General Comments

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