INT15173

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Context Info
Confidence 0.49
First Reported 1991
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 59
Total Number 60
Disease Relevance 21.89
Pain Relevance 5.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
neutrophils 30
macrophages 16
granulocytes 10
microglia 4
leukocytes 4
Itgam (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 4 99.72 Very High Very High Very High
Hippocampus 19 99.48 Very High Very High Very High
midbrain 12 99.36 Very High Very High Very High
Peripheral nerve injury 4 97.88 Very High Very High Very High
Inflammation 610 97.60 Very High Very High Very High
Morphine 6 97.14 Very High Very High Very High
cytokine 563 95.16 Very High Very High Very High
antagonist 10 93.44 High High
Pain 24 93.28 High High
Inflammatory response 141 93.20 High High
Disease Link Frequency Relevance Heat
Infection 1342 100.00 Very High Very High Very High
Adhesions 84 100.00 Very High Very High Very High
Respiratory Syncytial Virus 62 100.00 Very High Very High Very High
Parkinson's Disease 112 99.98 Very High Very High Very High
Obesity 126 99.84 Very High Very High Very High
Injury 183 99.82 Very High Very High Very High
Viral Infection 10 98.88 Very High Very High Very High
Mycobacterial Infection 305 98.16 Very High Very High Very High
Nervous System Injury 32 97.88 Very High Very High Very High
Hyperplasia 21 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Herein we show that f-MLP and substance P induce rapid changes in neutrophil morphology, migration, and adhesion molecule expression, including upregulation of Mo1 (CD11b/CD18) and shedding of LAM-1 (also known as LECAM-1, Leu8, or TQ-1, the human homologue of murine gp100MEL14).
Positive_regulation (changes) of Gene_expression (shedding) of CD11b/CD18 in neutrophil associated with adhesions and substance p
1) Confidence 0.49 Published 1991 Journal Blood Section Abstract Doc Link 1717072 Disease Relevance 0.41 Pain Relevance 0.29
However, the 4 mg/kg of A. camphorata decreased the levels of CD11b and both doses of treatment increased CD3 and CD19.
Positive_regulation (increased) of Gene_expression (levels) of CD11b
2) Confidence 0.45 Published 2010 Journal Nutr Cancer Section Abstract Doc Link 20574920 Disease Relevance 0.65 Pain Relevance 0.07
Morphine in combination with Tat also induced morphological changes in the BV-2 microglia from a quiescent to an activated morphology, with a dramatic increase in the expression of the microglial activation marker CD11b, as compared with cells exposed to either agent alone.
Positive_regulation (increase) of Gene_expression (expression) of CD11b in microglia associated with morphine
3) Confidence 0.45 Published 2009 Journal J. Neurovirol. Section Abstract Doc Link 19462331 Disease Relevance 0.94 Pain Relevance 0.84
Within the GR-1hi population, CD11b expression was not modified by the IR injury in either WT or MC3R-null animals; however, granulocytes from IR MC3R-null animals displayed an increased CD11b expression when compared with WT animals.
Positive_regulation (increased) of Gene_expression (expression) of CD11b in granulocytes associated with injury
4) Confidence 0.40 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.26 Pain Relevance 0
Conversely, HCT1026 significantly reduced MPTP-induced Mac-1 and PHOX expression in the ventral midbrain, supporting reduced microglial activation during the early phase of DAergic degeneration (Figure 7A, B).


Positive_regulation (induced) of Gene_expression (expression) of Mac-1 in midbrain associated with parkinson's disease and midbrain
5) Confidence 0.40 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.62 Pain Relevance 0.28
Moreover, 11a treatment attenuated expression of macrophage adhesion molecule-1 (Mac-1) on extravasated polymorphonuclear leukocytes (PMNs) which indicates that the activation was reduced.
Positive_regulation (attenuated) of Gene_expression (expression) of Mac-1 in polymorphonuclear leukocytes associated with adhesions
6) Confidence 0.39 Published 2009 Journal Bioorg. Med. Chem. Section Abstract Doc Link 19097798 Disease Relevance 0.88 Pain Relevance 0.40
In 10-days-old MPSIIIB mice, we observed increased CD11b staining and normal GFAP staining, suggesting that MIP1?
Positive_regulation (increased) of Gene_expression (staining) of CD11b
7) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.12 Pain Relevance 0
Increased CD11b staining and MIP1?
Positive_regulation (Increased) of Gene_expression (staining) of CD11b
8) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0 Pain Relevance 0
The increased expression of CR3 in phagocytes was caused by inhibition of prostaglandin E-2 (PGE-2) levels, which were significantly increased in neutrophils and macrophages upon E. coli infection.
Positive_regulation (increased) of Gene_expression (expression) of CR3 in phagocytes associated with infection
9) Confidence 0.31 Published 2010 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2882833 Disease Relevance 0.34 Pain Relevance 0
By taking advantage of the ability of flow cytometry to distinguish between CD11b+CD45dim microglia and infiltrating CD11b+CD45high macrophages, we showed that the number of IL-1?
Positive_regulation (infiltrating) of Gene_expression (macrophages) of CD11b in macrophages
10) Confidence 0.29 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.08 Pain Relevance 0.05
-expressing CD11b+CD45dim microglia increased from 3% of the total microglial population in unmanipulated mice to 15% of the total microglial population 24 hours after pMCAO (Figure 5D).
Positive_regulation (increased) of Gene_expression (microglia) of CD11b in microglia
11) Confidence 0.29 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0 Pain Relevance 0
By taking advantage of the ability of flow cytometry to distinguish between CD11b+CD45dim microglia and infiltrating CD11b+CD45high macrophages, we showed that the number of IL-1?
Positive_regulation (between) of Gene_expression (microglia) of CD11b in macrophages
12) Confidence 0.29 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.08 Pain Relevance 0.04
Two populations of CD11b+CD45high cells were visible on flow cytometric dot plots from mice exposed to 24 hours of pMCAO, which differed by expressing intermediate or high levels of CD11b (Figure 4C).
Positive_regulation (levels) of Gene_expression (expressing) of CD11b
13) Confidence 0.29 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0 Pain Relevance 0
These cells co-localized with activated CD11b+ microglia and CD11b+ macrophages/granulocytes observed in parallel sections (Figure 1A).
Positive_regulation (activated) of Gene_expression (microglia) of CD11b in granulocytes
14) Confidence 0.29 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0 Pain Relevance 0
Similarly there was a injury-induced increase in numbers of CD11b+CD45high macrophages/granulocytes that expressed TNF-?
Positive_regulation (increase) of Gene_expression (granulocytes) of CD11b in granulocytes associated with injury
15) Confidence 0.29 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.10 Pain Relevance 0
By taking advantage of the ability of flow cytometry to distinguish between CD11b+CD45dim microglia and infiltrating CD11b+CD45high macrophages, we showed that the number of IL-1?
Positive_regulation (between) of Gene_expression (macrophages) of CD11b in macrophages
16) Confidence 0.29 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.08 Pain Relevance 0.05
Self-renewal of AML stem cells and leukemic transformation has been previously linked to the lipid phosphatase PTEN (Yilmaz et al., 2006), which is predicted by some target prediction algorithms as a target of miR-29a (Lewis et al., 2005; Grimson et al., 2007); however, PTEN protein and mRNA were expressed at equivalent levels in WT and miR-29a–overexpressing Mac-1+ Gr-1+ granulocytes (unpublished data).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Mac-1 in granulocytes associated with myeloid leukemia
17) Confidence 0.28 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.76 Pain Relevance 0
Here, we demonstrate that following RSV infection a population of CTL co-expresses CD11ahi, CD11b and CD11c.
Positive_regulation (following) of Gene_expression (expresses) of CD11b associated with infection and respiratory syncytial virus
18) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.83 Pain Relevance 0.07
We also investigated potential changes in the levels of neutrophil activation in terms of surface expression of L-selectin and CD11b (fig. 8).
Positive_regulation (activation) of Gene_expression (expression) of CD11b in neutrophil
19) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.12 Pain Relevance 0.03
Our studies also demonstrated that the IL-10–induced bactericidal activity of neutrophils and macrophages is caused by increased expression of CR3 and TLR4, which was suppressed during the infection without treatment.
Positive_regulation (increased) of Gene_expression (expression) of CR3 in neutrophils associated with infection
20) Confidence 0.26 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.67 Pain Relevance 0.16

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