INT151736

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 9.77
Pain Relevance 4.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Anatomy Link Frequency
plasma 1
Th17 cells 1
Th1 cells 1
B cell 1
effector T cell 1
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 185 100.00 Very High Very High Very High
cytokine 293 99.96 Very High Very High Very High
rheumatoid arthritis 57 99.84 Very High Very High Very High
Neuritis 93 97.24 Very High Very High Very High
Arthritis 89 94.48 High High
imagery 25 88.80 High High
Multiple sclerosis 42 87.04 High High
chemokine 20 84.80 Quite High
Glutamate 1 80.16 Quite High
pain pelvic 1 72.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 189 100.00 Very High Very High Very High
Rheumatoid Arthritis 57 99.84 Very High Very High Very High
Sprains And Strains 63 99.58 Very High Very High Very High
Asthma 116 99.16 Very High Very High Very High
Gastritis 57 98.92 Very High Very High Very High
Disease 155 98.72 Very High Very High Very High
Encephalitis 16 98.36 Very High Very High Very High
Autoimmune Disease 39 98.20 Very High Very High Very High
Adhesions 12 97.60 Very High Very High Very High
Optic Neuritis 68 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, disrupting the interaction of the Th1-specific regulatory molecule Tim-3, with its ligand, significantly exacerbates adhesion formation.
Th1 Binding (interaction) of associated with adhesions
1) Confidence 0.26 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18453619 Disease Relevance 1.02 Pain Relevance 0.12
Taken together, PSP exerted an adjuvant effect on OVA-induced IgE and IL-4 levels in all three strains, while there was no association between the Th1-associated parameters IgG2a and IFN-?.
Th1 Neg (no) Binding (association) of in PSP associated with sprains and strains
2) Confidence 0.22 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.40 Pain Relevance 0.30
Interestingly, however, infectious reagents such as LPS or the TH1 cytokine INF-?
TH1 Binding (Interestingly) of associated with cytokine
3) Confidence 0.20 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.16 Pain Relevance 0.12
The cytokine profiles for mutated peptide vaccinated mice indicated a peptide-specific response with elevated Th1 (TNF-?
Th1 Binding (indicated) of associated with cytokine
4) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2270279 Disease Relevance 0.24 Pain Relevance 0.29
These results were confirmed by findings of human Th1/Th2 cytokines in plasma of G93A mice treated with different cell doses.
Th1 Binding (findings) of in plasma associated with cytokine
5) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.07 Pain Relevance 0.42
Hence, also patients suffering from allergic asthma displayed mixed T helper cell responses, reflected by the occurrence of TH2 specific IL-13 and of TH1 specific IFN-?
TH1 Binding (reflected) of associated with asthma
6) Confidence 0.16 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.65 Pain Relevance 0.12
phagocytosis by cytokines known to promote effector T cell function, and found that the pro-inflammatory Th1-type cytokines IFN-?
Th1 Binding (found) of in effector T cell associated with inflammation and cytokine
7) Confidence 0.15 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.40 Pain Relevance 0.34
Shifting the Th1/Th2 to the Th1 direction is one mechanism underlying increased susceptibility to EAN in apoE-deficient mice.
Th1 Binding (Shifting) of associated with neuritis
8) Confidence 0.12 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 1.07 Pain Relevance 0.85
Consequently, the release of the Th1 associated cytokines IL-12, IFN-?
Th1 Binding (associated) of associated with cytokine
9) Confidence 0.12 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.27 Pain Relevance 0.30
Both Th1 and Th17 cells have been recognized in RA; however, it remains unclear whether Th1 and/or Th17 cells drive disease chronicity [52].
Th1 Binding (recognized) of in Th17 cells associated with rheumatoid arthritis and disease
10) Confidence 0.10 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.74 Pain Relevance 0.38
While IgG1 antibodies are present in Th1 and Th2 immunity, B cell isotype switching to IgG2a requires IFN-?
Th1 Binding (immunity) of in B cell
11) Confidence 0.09 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.03
Through the action of the newly discovered Th17 mechanism, but not Th1 or Th2, the T cells, IgH-producing B cells, and antigen that causes CNS lesion interact to produce the pathophysiology of mouse encephalomyelitis and optic neuritis.
Th1 Binding (interact) of in T cells associated with optic neuritis, encephalitis and neuritis
12) Confidence 0.07 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964037 Disease Relevance 1.49 Pain Relevance 0.55
Recently, the role of naturally occurring CD4+CD25+ Treg in Th1-, Th2-, and Th17-mediated gastritis has been described [71] and TGF?
Th1 Binding (occurring) of associated with gastritis
13) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896618 Disease Relevance 1.37 Pain Relevance 0.07
T80 cells are activated due to interaction with Th1 cells and cytokines and have a natural half-life.
Th1 Binding (interaction) of in Th1 cells associated with cytokine
14) Confidence 0.04 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.48 Pain Relevance 0.08
To do so, they mentally rotated their hands to match them with the hand-stimuli.
hand Binding (match) of
15) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2726952 Disease Relevance 0.42 Pain Relevance 0.08

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