INT15174

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Context Info
Confidence 0.73
First Reported 1991
Last Reported 2011
Negated 17
Speculated 10
Reported most in Abstract
Documents 238
Total Number 249
Disease Relevance 104.92
Pain Relevance 29.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
neutrophils 37
macrophages 31
microglia 23
granulocytes 15
F4/80 12
Itgam (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2282 99.98 Very High Very High Very High
Inflammation 2973 99.92 Very High Very High Very High
opiate 8 99.92 Very High Very High Very High
Sciatic nerve 87 99.90 Very High Very High Very High
Angina 29 99.88 Very High Very High Very High
cINOD 289 99.84 Very High Very High Very High
midbrain 75 99.76 Very High Very High Very High
Inflammatory mediators 139 99.64 Very High Very High Very High
Neuropathic pain 191 99.58 Very High Very High Very High
Hippocampus 148 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 1100 100.00 Very High Very High Very High
Adhesions 532 100.00 Very High Very High Very High
Obesity 453 99.98 Very High Very High Very High
INFLAMMATION 3733 99.92 Very High Very High Very High
Cv General 3 Under Development 40 99.88 Very High Very High Very High
Arthritis 502 99.84 Very High Very High Very High
Parkinson's Disease 995 99.82 Very High Very High Very High
Infection 4276 99.74 Very High Very High Very High
Bacteremia 623 99.74 Very High Very High Very High
Neuropathic Pain 224 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess the site of leukocyte activation in unstable angina, the expression of neutrophil and monocyte CD11B/CD18 adhesion molecules in 26 patients was measured from blood samples taken from the coronary ostium, the coronary sinus, and the coronary artery just distal to the culprit lesion (postobstructive chamber).
Gene_expression (expression) of CD11B/CD18 in neutrophil associated with angina and adhesions
1) Confidence 0.73 Published 1996 Journal Am. J. Cardiol. Section Abstract Doc Link 8806345 Disease Relevance 0.51 Pain Relevance 0.28
U-50,488H also decreased neutrophil expression of the beta(2) integrin CD11b/CD18 (Mac-1) and adhesion to plastic in a naloxone-reversible manner.
Gene_expression (expression) of CD11b/CD18 in neutrophil associated with narcan and adhesions
2) Confidence 0.72 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11239930 Disease Relevance 0.18 Pain Relevance 0.78
U-50,488H also decreased neutrophil expression of the beta(2) integrin CD11b/CD18 (Mac-1) and adhesion to plastic in a naloxone-reversible manner.
Gene_expression (expression) of Mac-1 in neutrophil associated with narcan and adhesions
3) Confidence 0.72 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11239930 Disease Relevance 0.18 Pain Relevance 0.78
Opioid receptors on bone marrow neutrophils modulate chemotaxis and CD11b/CD18 expression.
Gene_expression (expression) of CD11b/CD18 in neutrophils associated with opioid receptor
4) Confidence 0.72 Published 2001 Journal Eur. J. Pharmacol. Section Title Doc Link 11239930 Disease Relevance 0.15 Pain Relevance 0.84
However, the 4 mg/kg of A. camphorata decreased the levels of CD11b and both doses of treatment increased CD3 and CD19.
Gene_expression (levels) of CD11b
5) Confidence 0.70 Published 2010 Journal Nutr Cancer Section Abstract Doc Link 20574920 Disease Relevance 0.65 Pain Relevance 0.07
Herein we show that f-MLP and substance P induce rapid changes in neutrophil morphology, migration, and adhesion molecule expression, including upregulation of Mo1 (CD11b/CD18) and shedding of LAM-1 (also known as LECAM-1, Leu8, or TQ-1, the human homologue of murine gp100MEL14).
Gene_expression (shedding) of CD11b/CD18 in neutrophil associated with adhesions and substance p
6) Confidence 0.65 Published 1991 Journal Blood Section Abstract Doc Link 1717072 Disease Relevance 0.40 Pain Relevance 0.28
Since it has been documented that the expression of E-selectin and Mac-1 is regulated either directly or indirectly by the transcription factor NF kappa B, our studies provide in vivo evidence that tepoxalin is a potent inhibitor of NF kappa B-mediated events in animal models and this novel molecular mechanism clearly defines it as a new class of anti-inflammatory compounds.
Gene_expression (expression) of Mac-1 associated with inflammation
7) Confidence 0.65 Published 1996 Journal Eur. J. Immunol. Section Abstract Doc Link 8566054 Disease Relevance 0.64 Pain Relevance 0.32
Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac-1 and E-selectin expression.
Gene_expression (expression) of Mac-1 in neutrophil associated with inflammation
8) Confidence 0.65 Published 1996 Journal Eur. J. Immunol. Section Title Doc Link 8566054 Disease Relevance 0.89 Pain Relevance 0.39
To assess the site of leukocyte activation in unstable angina, the expression of neutrophil and monocyte CD11B/CD18 adhesion molecules in 26 patients was measured from blood samples taken from the coronary ostium, the coronary sinus, and the coronary artery just distal to the culprit lesion (postobstructive chamber).
Gene_expression (expression) of CD11B/CD18 in neutrophil associated with angina and adhesions
9) Confidence 0.63 Published 1996 Journal Am. J. Cardiol. Section Abstract Doc Link 8806345 Disease Relevance 0.51 Pain Relevance 0.28
Opioid receptors on bone marrow neutrophils modulate chemotaxis and CD11b/CD18 expression.
Gene_expression (expression) of CD11b/CD18 in neutrophils associated with opioid receptor
10) Confidence 0.62 Published 2001 Journal Eur. J. Pharmacol. Section Title Doc Link 11239930 Disease Relevance 0.15 Pain Relevance 0.84
U-50,488H also decreased neutrophil expression of the beta(2) integrin CD11b/CD18 (Mac-1) and adhesion to plastic in a naloxone-reversible manner.
Gene_expression (expression) of CD11b/CD18 in neutrophil associated with narcan and adhesions
11) Confidence 0.62 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11239930 Disease Relevance 0.18 Pain Relevance 0.78
Conversely, HCT1026 significantly reduced MPTP-induced Mac-1 and PHOX expression in the ventral midbrain, supporting reduced microglial activation during the early phase of DAergic degeneration (Figure 7A, B).


Gene_expression (expression) of Mac-1 in midbrain associated with parkinson's disease and midbrain
12) Confidence 0.62 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.62 Pain Relevance 0.28
HCT1026-induced neuroprotection was associated with a marked down-regulation of activated microglial cell number and a signiof ficant decrease of MPTP-induced pro-inflammatory mediators, including iNOS, Mac-1 and PHOX expression, as well reduced 3-NT formationin SNpc DAergic neurons, suggesting that a switch in microglia pro-inflammatory phenotype might contribute to nigrostriatal neuroprotection.
Gene_expression (expression) of Mac-1 in microglial cell associated with parkinson's disease, inflammatory mediators and inflammation
13) Confidence 0.62 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.03 Pain Relevance 0.16
Mac-1 and PHOX expression in the ventral midbrain (VM)
Gene_expression (expression) of Mac-1 in ventral associated with midbrain
14) Confidence 0.62 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.34 Pain Relevance 0.22
Moreover, 11a treatment attenuated expression of macrophage adhesion molecule-1 (Mac-1) on extravasated polymorphonuclear leukocytes (PMNs) which indicates that the activation was reduced.
Gene_expression (expression) of Mac-1 in polymorphonuclear leukocytes associated with adhesions
15) Confidence 0.60 Published 2009 Journal Bioorg. Med. Chem. Section Abstract Doc Link 19097798 Disease Relevance 0.88 Pain Relevance 0.40
To assess the inflammatory response, we measured myeloperoxidase (MPO) in the organs, and CD 11b and major histocompatibility complex (MHC) II-positive cells in the blood.
Gene_expression (positive) of CD 11b in blood associated with inflammatory response and urological neuroanatomy
16) Confidence 0.58 Published 2010 Journal APMIS Section Abstract Doc Link 20132173 Disease Relevance 1.44 Pain Relevance 0.34
Morphine in combination with Tat also induced morphological changes in the BV-2 microglia from a quiescent to an activated morphology, with a dramatic increase in the expression of the microglial activation marker CD11b, as compared with cells exposed to either agent alone.
Gene_expression (expression) of CD11b in microglia associated with morphine
17) Confidence 0.58 Published 2009 Journal J. Neurovirol. Section Abstract Doc Link 19462331 Disease Relevance 0.93 Pain Relevance 0.83
Interestingly, we detected no decrease in surface expression of CR3 or any of the Fc?
Gene_expression (expression) of CR3
18) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.84 Pain Relevance 0.03
CD11b is a leukocyte-associated antigen expressed on monocytes, macrophages, and granulocytes [50].
Gene_expression (expressed) of CD11b in macrophages
19) Confidence 0.58 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1929071 Disease Relevance 0 Pain Relevance 0
Expression of neutrophil and monocyte CD11B/CD18 adhesion molecules at different sites of the coronary tree in unstable angina pectoris.
Gene_expression (Expression) of CD11B/CD18 in monocyte associated with angina and adhesions
20) Confidence 0.57 Published 1996 Journal Am. J. Cardiol. Section Title Doc Link 8806345 Disease Relevance 0.56 Pain Relevance 0.32

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