INT151745

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.58
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (METTL3) methyltransferase activity (METTL3) RNA binding (METTL3)
nucleus (METTL3)
Anatomy Link Frequency
colon 2
METTL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 3 83.64 Quite High
Endogenous opioid 1 78.36 Quite High
Opioid 2 77.68 Quite High
agonist 16 76.56 Quite High
mu opioid receptor 1 75.00 Quite High
Kinase C 188 72.60 Quite High
cerebral cortex 1 61.60 Quite High
cINOD 4 57.04 Quite High
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 4 99.84 Very High Very High Very High
Neurodegenerative Disease 1 80.48 Quite High
Hyperplasia 5 75.68 Quite High
Reprotox - General 1 8 69.44 Quite High
Cancer 64 67.48 Quite High
Apoptosis 12 66.76 Quite High
Cervical Cancer 4 66.12 Quite High
INFLAMMATION 4 56.80 Quite High
Aging 16 25.36 Quite Low
Repression 16 7.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results have also been confirmed by studying OR mRNA expression in the VZ and SVZ.
Negative_regulation (studying) of Gene_expression (expression) of OR mRNA
1) Confidence 0.11 Published 2008 Journal Neurosci. Res. Section Abstract Doc Link 18455254 Disease Relevance 0.16 Pain Relevance 0.36
The exposure of PBMCs to growth medium containing 10% NHS had resulted in a gradual decrease in the mRNA levels of c-myc, PPAR?
Negative_regulation (decrease) of Gene_expression (levels) of mRNA
2) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
M 25OH-C + Antibody against Receptor Ck' culture system, 25OH-C repressed hTERT mRNA levels by inhibiting c-myc mRNA expression (Figure 4).
Negative_regulation (inhibiting) of Gene_expression (expression) of mRNA
3) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.26 Pain Relevance 0.06
12,14 – prostaglandin J2 has been shown to down-regulate c-myc mRNA and protein expression in colon cancer cells and leukemic cell lines [34,35].
Negative_regulation (down-regulate) of Gene_expression (expression) of mRNA in colon associated with colon cancer
4) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.17 Pain Relevance 0.22
mRNA expression also followed a similar pattern of time-dependent increase and decrease though the fold increase was less as compared to that seen in hTERT mRNA expression (Figure 5).
Negative_regulation (decrease) of Gene_expression (expression) of mRNA
5) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0

General Comments

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