INT151747

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 17.48
Pain Relevance 17.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (PSMD2) cytosol (PSMD2) nucleoplasm (PSMD2)
small molecule metabolic process (PSMD2) cellular nitrogen compound metabolic process (PSMD2)
Anatomy Link Frequency
PPC 3
cingulate cortex 2
insular cortex 1
aorta 1
insula 1
PSMD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatosensory cortex 21 100.00 Very High Very High Very High
primary somatosensory cortex 8 100.00 Very High Very High Very High
Anterior cingulate cortex 36 99.70 Very High Very High Very High
amygdala 11 99.66 Very High Very High Very High
insula 30 99.64 Very High Very High Very High
magnetoencephalography 15 99.54 Very High Very High Very High
Pin-prick hyperalgesia 9 99.48 Very High Very High Very High
allodynia 57 99.42 Very High Very High Very High
Thalamus 21 98.84 Very High Very High Very High
Pain 197 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 187 99.92 Very High Very High Very High
Neuropathic Pain 59 99.42 Very High Very High Very High
Hyperalgesia 44 99.08 Very High Very High Very High
Pain 269 98.44 Very High Very High Very High
Complex Regional Pain Syndromes 14 98.00 Very High Very High Very High
Colon Cancer 40 95.28 Very High Very High Very High
Sprains And Strains 26 94.56 High High
Genetic Predisposition To Disease 1 91.32 High High
Somatoform Disorder 6 91.04 High High
Bacterial Respiratory Disease 2 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subgroup analysis using rating-weighted predictors revealed activation of the contralateral thalamus, anterior cingulate cortex, and amygdala and a bilateral activation of S1, S2, and insular cortex and prefrontal cortices in allodynia-experienced subjects.
Positive_regulation (activation) of S2 in insular cortex associated with allodynia, thalamus, amygdala and anterior cingulate cortex
1) Confidence 0.68 Published 2008 Journal J Pain Section Abstract Doc Link 18455481 Disease Relevance 1.23 Pain Relevance 1.54
In the exercise group the S2 amplitude percentage increase was similar in the 13 control and in the 86 patients (+ 140 ± 123% vs. 132 ± 102%, p = ns)
Positive_regulation (increase) of S2
2) Confidence 0.59 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2531180 Disease Relevance 0.43 Pain Relevance 0
We found pin-prick-induced sequential activation of contralateral S1, PPC and S2 as well as activation of ipsilateral S2 during both pin-prick hyperalgesia and normal pin-prick pain.
Positive_regulation (activation) of S2 in PPC associated with pain, hyperalgesia and pin-prick hyperalgesia
3) Confidence 0.55 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19346142 Disease Relevance 1.38 Pain Relevance 1.47
We found pin-prick-induced sequential activation of contralateral S1, PPC and S2 as well as activation of ipsilateral S2 during both pin-prick hyperalgesia and normal pin-prick pain.
Positive_regulation (activation) of S2 in PPC associated with pain, hyperalgesia and pin-prick hyperalgesia
4) Confidence 0.55 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19346142 Disease Relevance 1.38 Pain Relevance 1.43
Higher activations of bilateral S2 were significantly correlated with higher scores for the sensory-discriminative component during condition 2.
Positive_regulation (activations) of S2
5) Confidence 0.48 Published 2009 Journal Eur J Pain Section Abstract Doc Link 19231261 Disease Relevance 0.33 Pain Relevance 0.49
In contrast, allodynia-inexperienced subjects only activated contralateral S1 and bilateral S2.
Positive_regulation (activated) of S2 associated with allodynia
6) Confidence 0.40 Published 2008 Journal J Pain Section Abstract Doc Link 18455481 Disease Relevance 1.21 Pain Relevance 1.57
The group analysis of all subjects revealed that tactile stimulation activated contralateral somatosensory cortices (S1 [primary] and S2 [secondary]), but the imagination of allodynia led to an additional activation of anterior cingulate cortex and bilateral activation of S2, insular cortex, and prefrontal cortices.
Positive_regulation (activation) of S2 in cingulate cortex associated with allodynia and anterior cingulate cortex
7) Confidence 0.40 Published 2008 Journal J Pain Section Abstract Doc Link 18455481 Disease Relevance 1.21 Pain Relevance 1.49
The group analysis of all subjects revealed that tactile stimulation activated contralateral somatosensory cortices (S1 [primary] and S2 [secondary]), but the imagination of allodynia led to an additional activation of anterior cingulate cortex and bilateral activation of S2, insular cortex, and prefrontal cortices.
Positive_regulation (activated) of S2 in cingulate cortex associated with allodynia and anterior cingulate cortex
8) Confidence 0.40 Published 2008 Journal J Pain Section Abstract Doc Link 18455481 Disease Relevance 1.20 Pain Relevance 1.46
According to the physiological basis, in these case the blunted S2 increase should be related to a diminished driving pressure between the aorta and the left ventricle, with delayed or altered active LV relaxation.
Positive_regulation (increase) of S2 in aorta
9) Confidence 0.40 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2531180 Disease Relevance 0.72 Pain Relevance 0
Mean S2 percentage increase was + 133 ± 104% in the 99 exercise patients, + 2 ± 22% in the 41 dipyridamole patients and + 31 ± 27% in the 6 pacing patients (p < 0.05 between groups) (Table 2).
Positive_regulation (increase) of S2
10) Confidence 0.40 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2531180 Disease Relevance 0.38 Pain Relevance 0
S2 percentage increase was + 133 ± 104% in the 99 exercise, + 2 ± 22% in the 41 dipyridamole, and + 31 ± 27% in the 6 pacing patients (p < 0.05).
Positive_regulation (increase) of S2
11) Confidence 0.40 Published 2008 Journal Cardiovasc Ultrasound Section Abstract Doc Link PMC2531180 Disease Relevance 0.19 Pain Relevance 0
When relaxation was hyperactive, decreasing T less than 65% of control, S2 intensity was increased.
Positive_regulation (increased) of S2
12) Confidence 0.40 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2531180 Disease Relevance 0.10 Pain Relevance 0
We found pin-prick-induced sequential activation of contralateral S1, PPC and S2 as well as activation of ipsilateral S2 during both pin-prick hyperalgesia and normal pin-prick pain.
Positive_regulation (activation) of S2 in PPC associated with pain, hyperalgesia and pin-prick hyperalgesia
13) Confidence 0.37 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19346142 Disease Relevance 1.38 Pain Relevance 1.42
MEG revealed an increased activation of bilateral secondary somatosensory cortices (S2) during condition 2 compared to condition 1.
Positive_regulation (activation) of S2 associated with magnetoencephalography
14) Confidence 0.32 Published 2009 Journal Eur J Pain Section Abstract Doc Link 19231261 Disease Relevance 0.33 Pain Relevance 0.49
It potentially could be attributed to activation in S1 and S2 and recorded together, since both are activated by noxious stimuli [13].
Positive_regulation (activation) of S2
15) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778627 Disease Relevance 0.22 Pain Relevance 0.38
Subgroup analysis using rating-weighted predictors revealed activation of the contralateral thalamus, anterior cingulate cortex, and amygdala and a bilateral activation of S1, S2, and insular cortex and prefrontal cortices in allodynia-experienced subjects.
Positive_regulation (activation) of S2 in prefrontal associated with allodynia, thalamus, amygdala and anterior cingulate cortex
16) Confidence 0.23 Published 2008 Journal J Pain Section Abstract Doc Link 18455481 Disease Relevance 1.23 Pain Relevance 1.54
Maihöfner et al. [26] observed activations in the S1 and S2 cortex, insula, PFC, and in the ACC during pin-prick stimulation of CRPS patients who experience hyperalgesia.
Positive_regulation (activations) of S2 in insula associated with somatosensory cortex, hyperalgesia, primary somatosensory cortex, reflex sympathetic dystrophy, insula and anterior cingulate cortex
17) Confidence 0.23 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.53 Pain Relevance 1.96
Levels in D2 were higher than S2 or controls for MCP-1 and M-CSF.
Positive_regulation (higher) of S2
18) Confidence 0.10 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 0.07 Pain Relevance 0.37
Several proteasome genes were upregulated by the high concentration of curcumin after 12 or 24 hours: PSMA1, PSMA7, PSMB2 after 12 hours and PSMB6, PSMC4, PSMD2 after 24 hours (data not shown).
Positive_regulation (upregulated) of PSMD2
19) Confidence 0.09 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.25 Pain Relevance 0
Maihöfner et al. [26] observed activations in the S1 and S2 cortex, insula, PFC, and in the ACC during pin-prick stimulation of CRPS patients who experience hyperalgesia.
Positive_regulation (activations) of S2 in cortex associated with somatosensory cortex, hyperalgesia, primary somatosensory cortex, reflex sympathetic dystrophy, insula and anterior cingulate cortex
20) Confidence 0.08 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.53 Pain Relevance 1.96

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