INT151752

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.99
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) histone binding (Snca)
plasma membrane (Snca) cytoskeleton (Snca) nucleus (Snca)
Anatomy Link Frequency
striatum 2
brain 2
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 1 98.16 Very High Very High Very High
amygdala 3 97.40 Very High Very High Very High
Substantia nigra 21 97.00 Very High Very High Very High
Ventral tegmentum 1 96.28 Very High Very High Very High
alcohol 10 95.40 Very High Very High Very High
withdrawal 2 92.24 High High
opiate 2 73.84 Quite High
Dopamine 6 46.00 Quite Low
ketamine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 26 100.00 Very High Very High Very High
Alcohol Addiction 3 92.56 High High
Disease 28 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Toxicity 8 5.00 Very Low Very Low Very Low
Parkinson's Disease 4 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of alpha-synuclein mRNA remained unchanged in all brain regions examined (the striatum, nucleus accumbens, amygdala, substantia nigra, ventral tegmental area). alpha-Synuclein mRNA was up-regulated in the whole blood 48 h after alcohol withdrawal.
Neg (unchanged) Positive_regulation (unchanged) of Transcription (levels) of alpha-synuclein mRNA in brain associated with ventral tegmentum, nucleus accumbens, substantia nigra, withdrawal, amygdala and alcohol
1) Confidence 0.50 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18456291 Disease Relevance 0.25 Pain Relevance 0.90
NAC treated PDGFb-SNCA transgenic mice also exhibited 81.1% fewer cells containing SNCA-positive intracytoplasmic inclusions in the striatum (Fig. 2H; p?
Positive_regulation (-) of Transcription (transgenic mice) of SNCA in striatum associated with targeted disruption
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.74 Pain Relevance 0.03

General Comments

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