INT151753

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.99
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) histone binding (Snca)
plasma membrane (Snca) cytoskeleton (Snca) nucleus (Snca)
Anatomy Link Frequency
striatum 1
brain 1
cortex 1
hippocampus 1
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 84 99.18 Very High Very High Very High
Nucleus accumbens 1 97.40 Very High Very High Very High
amygdala 3 96.64 Very High Very High Very High
Substantia nigra 37 96.24 Very High Very High Very High
Ventral tegmentum 1 95.52 Very High Very High Very High
alcohol 14 95.40 Very High Very High Very High
withdrawal 2 91.48 High High
opiate 2 72.32 Quite High
Dopamine 14 45.96 Quite Low
imagery 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 30 100.00 Very High Very High Very High
Alcohol Addiction 3 91.80 High High
Neuroblastoma 4 83.64 Quite High
Disease 112 69.44 Quite High
Dementia 12 54.52 Quite High
Parkinson's Disease 40 54.00 Quite High
Cognitive Disorder 4 29.36 Quite Low
Multiple System Atrophy 12 18.96 Low Low
Alzheimer's Dementia 8 9.20 Low Low
Toxicity 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We initially designed nine siRNAs (Mayo 1–9) which are complementary to the SNCA transcript in the coding region and the 3'-UTR region (Additional file 1).
Transcription (transcript) of SNCA
1) Confidence 0.69 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.08 Pain Relevance 0
The levels of alpha-synuclein mRNA remained unchanged in all brain regions examined (the striatum, nucleus accumbens, amygdala, substantia nigra, ventral tegmental area). alpha-Synuclein mRNA was up-regulated in the whole blood 48 h after alcohol withdrawal.
Transcription (levels) of alpha-synuclein mRNA in brain associated with ventral tegmentum, nucleus accumbens, substantia nigra, withdrawal, amygdala and alcohol
2) Confidence 0.69 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18456291 Disease Relevance 0.25 Pain Relevance 0.89
NAC treated PDGFb-SNCA transgenic mice also exhibited 81.1% fewer cells containing SNCA-positive intracytoplasmic inclusions in the striatum (Fig. 2H; p?
Transcription (transgenic mice) of SNCA in striatum associated with targeted disruption
3) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.74 Pain Relevance 0.03
We then injected them into the Cornu Ammonis (CA1) of the hippocampus of mice and demonstrated a reduction in SNCA mRNA levels by quantitative reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization throughout the hippocampus and cortex.
Transcription (levels) of SNCA in cortex associated with hippocampus
4) Confidence 0.53 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.42 Pain Relevance 0.10
In the absence of plasmid co-transfection, quantitative RT-PCR showed that the endogenous SNCA mRNA transcript was reduced by 89% for Mayo 2, 52% for Mayo 7 and 67% for Mayo 8 (Additional file 3).
Transcription (transcript) of SNCA
5) Confidence 0.53 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.08 Pain Relevance 0
We then injected them into the Cornu Ammonis (CA1) of the hippocampus of mice and demonstrated a reduction in SNCA mRNA levels by quantitative reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization throughout the hippocampus and cortex.
Transcription (levels) of SNCA in hippocampus associated with hippocampus
6) Confidence 0.18 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.42 Pain Relevance 0.10

General Comments

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