INT151774

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 20.15
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
brains 6
neuronal 1
ventricle 1
epithelial cells 1
ganglion cells 1
Mtor (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 80 98.64 Very High Very High Very High
Pyramidal cell 72 96.32 Very High Very High Very High
cva 9 95.18 Very High Very High Very High
metalloproteinase 4 84.76 Quite High
Peripheral nervous system 1 75.04 Quite High
cryotherapy 1 74.72 Quite High
Hippocampus 60 73.60 Quite High
Kinase C 6 73.20 Quite High
headache 1 73.12 Quite High
imagery 35 62.68 Quite High
Disease Link Frequency Relevance Heat
Cyst 173 99.92 Very High Very High Very High
Polycystic Kidney Disease 329 99.68 Very High Very High Very High
Parkinson's Disease 720 99.48 Very High Very High Very High
Disease 1035 99.16 Very High Very High Very High
Targeted Disruption 192 98.76 Very High Very High Very High
Fibrosis 75 98.64 Very High Very High Very High
Recurrence 14 98.64 Very High Very High Very High
Mantle-cell Lymphoma 33 98.44 Very High Very High Very High
Breast Cancer 4 98.40 Very High Very High Very High
Tuberous Sclerosis 51 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the developing nervous system, constitutive activation of the AKT/mTOR (mammalian target of rapamycin) pathway in myelinating glial cells is associated with hypermyelination of the brain, but is reportedly insufficient to drive myelination by Schwann cells.
Positive_regulation (activation) of mTOR in Schwann cells
1) Confidence 0.45 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592216 Disease Relevance 0 Pain Relevance 0.04
This immunohistochemical pattern suggests that the large dysplastic ganglion cells (the gangliocytomatous component) forming the greater part of the lesion were associated with activation of the phosphatidylinositol 3-kinase-PTEN/Akt/mTOR signaling pathway, a feature previously reported in LDD.
Positive_regulation (activation) of mTOR in ganglion cells associated with ganglion cysts and disease
2) Confidence 0.41 Published 2007 Journal J. Neurosurg. Section Abstract Doc Link 18459885 Disease Relevance 1.11 Pain Relevance 0.07
The reduction in the level of TBARS and increase in FRAP were significantly higher in the antioxidant group compared with the placebo group (TBARS: placebo 1.2+/-2.7 vs antioxidant 3.5+/-3.4 nmol/mL; P= .001; 95% CI 0.96, 3.55; FRAP: placebo -5.6+/-154.9 vs antioxidant 97.8+/-134.9 microMFe(+2) liberated, P= .001, 95% CI 44.98, 161.7).
Positive_regulation (increase) of FRAP
3) Confidence 0.40 Published 2009 Journal Gastroenterology Section Body Doc Link 18952082 Disease Relevance 0.16 Pain Relevance 0
Activation of the mammalian target of rapamicin (mTOR) signaling observed in microarray confirms the increase in protein synthesis in HF NZO.
Positive_regulation (Activation) of mTOR associated with obesity
4) Confidence 0.12 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.72 Pain Relevance 0.11
Moreover, mTOR overactivation has been shown to cause increased mitochondrial biogenesis and accumulation of reactive oxygen species in distinct model systems[36], suggesting that the activation of mTOR pathway might be responsible for the detrimental effects of MEF2C activation and vice-versa to the beneficial effects of MEF2C depletion in the mechanically overloaded hearts.
Positive_regulation (activation) of mTOR in hearts
5) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.18 Pain Relevance 0
Remarkably, the restoration of the activity of this signaling complex after supplementation with leucine was accompanied by suppression of the anti-hypertrophic of MEF2C depletion, indicating that the defective activation of mTOR/S6K pathway is a critical component of the beneficial effects of MEF2C depletion in the cardiac phenotype of TAC mice.
Positive_regulation (activation) of mTOR
6) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.27 Pain Relevance 0
The data indicate that depletion of MEF2C is sufficient to markedly attenuate the hypertrophic growth and myocardial fibrosis of overloaded left ventricle by a mechanism dependent on defective activation of mTOR/S6K pathway.
Positive_regulation (activation) of mTOR in ventricle associated with fibrosis
7) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.42 Pain Relevance 0.05
The mechanisms through which increased mTor and reduced Atg7 might participate in the neuropathology of DLB are not completely clear.
Positive_regulation (increased) of mTor associated with parkinson's disease
8) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.93 Pain Relevance 0
In contrast, in DLB cases levels of neuronal mTor immunoreactivity were increased (Figure 2C, G), while the levels of neuronal Atg7 immunolabeling were reduced (Figure 2F, G).
Positive_regulation (increased) of mTor in neuronal associated with parkinson's disease
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.91 Pain Relevance 0.08
Alternatively, reduced mitochondrial function may also inactivate mTOR activity[37], however further studies are needed to clarify this issue.
Spec (may) Positive_regulation (inactivate) of mTOR
10) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.34 Pain Relevance 0.03
Taken together, these results support the possibility that alterations in the autophagy pathway and more specifically in mTor and Atg7 are associated with accumulation of ?
Positive_regulation (alterations) of mTor
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.41 Pain Relevance 0
Thus, we reasoned that supplementation with leucine might rescue the defective activation of mTOR/S6K complex after depletion of MEF2C.
Positive_regulation (activation) of mTOR
12) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.24 Pain Relevance 0
Therefore we next examined whether the anti-hypertrophic effect of MEF2C depletion is related to a defective activation of mTOR (mammalian Target of Rapamycin).
Positive_regulation (activation) of mTOR
13) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.26 Pain Relevance 0
The amino acid leucine is a potent activator of mTOR complex by a pathway distinct from TSC-2 (Tuberous Sclerosis Protein-2) complex phosphorylation[26], [27].
Positive_regulation (activator) of mTOR associated with tuberous sclerosis
14) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.26 Pain Relevance 0
Compared to non-demented controls and AD cases, levels of mTor and phosphorylated-mTor (p-mTor) were elevated in the brains of DLB cases (Figure 1A, C).
Positive_regulation (elevated) of mTor in brains associated with parkinson's disease and disease
15) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.77 Pain Relevance 0
Since in addition to the increase in mTor, we also observed a reduction in Atg7 levels in DLB and ?
Positive_regulation (increase) of mTor associated with parkinson's disease
16) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.37 Pain Relevance 0.09
We found that levels of mTor were increased and Atg7 levels were reduced in the brains of patients with DLB and a-syn tg mice.
Positive_regulation (levels) of mTor in brains associated with parkinson's disease
17) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.24 Pain Relevance 0
The increased levels of mTor and reduced Atg7 levels suggest there may be altered activation of the autophagy pathway in the brains of DLB patients.
Positive_regulation (increased) of mTor in brains associated with parkinson's disease
18) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.90 Pain Relevance 0.09
-syn tg mice might be in part related to increased levels of mTor, we investigated whether blocking mTor with rapamycin might promote ?
Positive_regulation (increased) of mTor
19) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.19 Pain Relevance 0.03
Compared to non-demented controls and AD cases, levels of mTor and phosphorylated-mTor (p-mTor) were elevated in the brains of DLB cases (Figure 1A, C).
Positive_regulation (elevated) of p-mTor in brains associated with parkinson's disease and disease
20) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.77 Pain Relevance 0

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