INT151777

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.97
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
C8-B4 2
skin 2
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 35 100.00 Very High Very High Very High
Cancer pain 3 100.00 Very High Very High Very High
Neuropathic pain 9 98.72 Very High Very High Very High
medulla 1 98.04 Very High Very High Very High
Calcitonin gene-related peptide 9 94.92 High High
Migraine 2 93.04 High High
Pain 7 88.92 High High
Trigeminal ganglion neurons 1 80.24 Quite High
adenocard 2 75.00 Quite High
antagonist 8 68.40 Quite High
Disease Link Frequency Relevance Heat
Cancer Pain 3 100.00 Very High Very High Very High
Neuropathic Pain 11 98.72 Very High Very High Very High
Skin Cancer 4 96.48 Very High Very High Very High
Headache 2 93.04 High High
Nociception 2 91.60 High High
Pain 4 88.92 High High
Breast Cancer 1 87.60 High High
Lung Cancer 1 86.88 High High
Cancer 4 82.76 Quite High
Ganglion Cysts 1 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This process is mediated via changes in the expression and function of P2X(3) receptors initially through enhanced trafficking and, later, perhaps through augmented synthesis of P2X(3) receptors.
Regulation (changes) of Gene_expression (expression) of P2X
1) Confidence 0.60 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.53 Pain Relevance 0.66
These results suggest that ATP and P2X, especially P2X(3), receptors are involved in skin cancer pain, due to the increased release of ATP and increased expression of P2X(3) receptors in the sensory neurons.
Regulation (involved) of Gene_expression (expression) of P2X in skin associated with cancer pain
2) Confidence 0.45 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525075 Disease Relevance 1.13 Pain Relevance 0.42
The effect of antidepressants on P2X responses in C8-B4 cells
Regulation (effect) of Gene_expression (responses) of P2X in C8-B4 associated with antidepressant
3) Confidence 0.17 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0.31 Pain Relevance 0.40

General Comments

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