INT15178

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Context Info
Confidence 0.56
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.51
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAM) plasma membrane (ITGAM)
Anatomy Link Frequency
neutrophils 12
leukocytes 2
ITGAM (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 7 99.76 Very High Very High Very High
substance P 2 99.72 Very High Very High Very High
Opioid 7 99.32 Very High Very High Very High
local anesthetic 6 98.32 Very High Very High Very High
Enkephalin 7 97.94 Very High Very High Very High
Potency 3 95.20 Very High Very High Very High
Inflammatory response 5 90.72 High High
Inflammation 44 88.32 High High
cva 5 82.60 Quite High
cytokine 27 82.48 Quite High
Disease Link Frequency Relevance Heat
Adhesions 52 100.00 Very High Very High Very High
Brain Injury 72 99.10 Very High Very High Very High
INFLAMMATION 61 90.32 High High
Drug Induced Neurotoxicity 2 83.32 Quite High
Intracranial Hypertension 4 82.60 Quite High
Pressure And Volume Under Development 5 81.40 Quite High
Injury 45 78.88 Quite High
Leukemia 1 69.92 Quite High
Leukocytosis 3 67.72 Quite High
Shock 7 61.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cationic local anesthetic lidocaine inhibited not only FMLP-induced O2- release in neutrophils but also FMLP-induced CD11b upregulation and LAM-1 downregulation on neutrophils in a dose-dependent manner.
Positive_regulation (induced) of Positive_regulation (upregulation) of CD11b in neutrophils associated with lidocaine and local anesthetic
1) Confidence 0.56 Published 1994 Journal Exp. Hematol. Section Abstract Doc Link 7513653 Disease Relevance 0.24 Pain Relevance 0.66
We have shown that: (1) met-enkephalin and beta-endorphin at physiological concentrations relevant to that of in vivo (10(-8) and 10(-6) M) enhanced fMLP, PMA or OZ stimulated chemiluminescence and induced chemotactic response, (2) High concentrations of beta-endorphin (10(-3) M) or met-enkephalin (10(-5) M) decreased the CL response of PMN in vitro, (3) The opioid peptides at lower concentrations resulted in CD11b and CD18 molecule up-regulation on neutrophils.
Positive_regulation (resulted) of Positive_regulation (up-regulation) of CD11b in neutrophils associated with enkephalin and opioid
2) Confidence 0.55 Published 1999 Journal Immunol. Lett. Section Abstract Doc Link 10232386 Disease Relevance 0 Pain Relevance 1.06
The up-regulation of CD11b induced by platelet-activating factor (PAF) priming was also inhibited by ropivacaine. fMLP increased adhesion of neutrophils to HUVECs, which was inhibited by ropivacaine.
Positive_regulation (induced) of Positive_regulation (up-regulation) of CD11b in neutrophils associated with adhesions
3) Confidence 0.47 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.40 Pain Relevance 0.36
The up-regulation of CD11b induced by platelet-activating factor (PAF) priming was also inhibited by ropivacaine. fMLP increased adhesion of neutrophils to HUVECs, which was inhibited by ropivacaine.
Positive_regulation (up-regulation) of Positive_regulation (induced) of CD11b in neutrophils associated with adhesions
4) Confidence 0.47 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.40 Pain Relevance 0.36
RESULTS: Indomethacin caused a concentration- and time-dependent upregulation of CD11b and CD18 expression and PMN adhesion to endothelial cells.
Positive_regulation (caused) of Positive_regulation (upregulation) of CD11b in PMN
5) Confidence 0.30 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
Results of this study show that leukocytes from TBI patients resuscitated with NS display rapid induction of constitutively expressed CD62L and activation of CD11b with translocation to the cell membrane from intracellular secretory granules [31].
Positive_regulation (induction) of Positive_regulation (activation) of CD11b in leukocytes associated with brain injury
6) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.06 Pain Relevance 0.15
Herein we show that f-MLP and substance P induce rapid changes in neutrophil morphology, migration, and adhesion molecule expression, including upregulation of Mo1 (CD11b/CD18) and shedding of LAM-1 (also known as LECAM-1, Leu8, or TQ-1, the human homologue of murine gp100MEL14).
Positive_regulation (changes) of Positive_regulation (upregulation) of Mo1 in neutrophil associated with adhesions and substance p
7) Confidence 0.05 Published 1991 Journal Blood Section Abstract Doc Link 1717072 Disease Relevance 0.41 Pain Relevance 0.28

General Comments

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