INT151782

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) mitochondrion (Creb1) plasma membrane (P2rx1)
nucleus (Creb1) DNA binding (Creb1) protein complex (P2rx1)
Anatomy Link Frequency
sensory neurons 3
Creb1 (Mus musculus)
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 9 100.00 Very High Very High Very High
Pain 3 85.20 High High
Trigeminal ganglion neurons 1 67.24 Quite High
medulla 1 52.52 Quite High
Migraine 2 47.52 Quite Low
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 66.92 Quite High
Headache 2 47.52 Quite Low
Nociception 1 46.08 Quite Low
Pain 3 43.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present data indicate a novel mechanism for enhancing P2X(3) receptor expression and function in trigeminal sensory neurons by CGRP via CREB phosphorylation.
Phosphorylation (phosphorylation) of CREB in sensory neurons Positive_regulation (enhancing) of Gene_expression (expression) of P2X in sensory neurons associated with calcitonin gene-related peptide
1) Confidence 0.41 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.07 Pain Relevance 0.44

General Comments

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