INT15179

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Context Info
Confidence 0.61
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 14.35
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (SELL) plasma membrane (SELL)
Anatomy Link Frequency
neutrophil 13
monocytes 11
leukocytes 4
brain 4
eosinophils 2
SELL (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 14 100.00 Very High Very High Very High
substance P 2 99.72 Very High Very High Very High
Inflammatory response 71 99.20 Very High Very High Very High
Angina 6 94.80 High High
Inflammation 392 90.92 High High
Catecholamine 22 89.04 High High
analgesia 20 88.16 High High
Opioid 67 85.60 High High
cytokine 256 84.76 Quite High
cva 33 82.60 Quite High
Disease Link Frequency Relevance Heat
Adhesions 484 100.00 Very High Very High Very High
Coronary Artery Disease 19 100.00 Very High Very High Very High
Nicotine Addiction 369 99.84 Very High Very High Very High
Diabetes Mellitus 7 99.44 Very High Very High Very High
Brain Injury 432 99.10 Very High Very High Very High
INFLAMMATION 538 98.84 Very High Very High Very High
Injury 275 97.84 Very High Very High Very High
Cv General 3 Under Development 13 94.80 High High
Worm Infection 13 87.84 High High
Cardiovascular Disease 7 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After conventional crystalloid resuscitation, we found that relative to healthy controls, brain-injured patients exhibit extensive leukocyte mobilization, with significantly enhanced PMN and monocyte surface expression of L-selectin (CD62L) and ?
Positive_regulation (enhanced) of Gene_expression (expression) of L-selectin in brain
1) Confidence 0.61 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.21 Pain Relevance 0.06
Results of this study show that leukocytes from TBI patients resuscitated with NS display rapid induction of constitutively expressed CD62L and activation of CD11b with translocation to the cell membrane from intracellular secretory granules [31].
Positive_regulation (induction) of Gene_expression (expressed) of CD62L in leukocytes associated with brain injury
2) Confidence 0.61 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.01 Pain Relevance 0.15
Expression of CD62L by PMNs and monocytes were elevated in the NS group across all sample times relative to control, whereas HSD treatment significantly down-regulated CD62L expression at all time points.
Positive_regulation (elevated) of Gene_expression (Expression) of CD62L in monocytes
3) Confidence 0.61 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.28 Pain Relevance 0
Measurement of cell surface expression of CD62L and CD11b
Positive_regulation (Measurement) of Gene_expression (expression) of CD62L
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.06 Pain Relevance 0.06
Thus increased expression of CD11b and decreased expression of CD62L by neutrophils and monocytes may play a central role as the mechanism by which leukocyte adhesion and consequently activation occurs following surgery [2], [21], [26].
Positive_regulation (increased) of Gene_expression (expression) of CD62L in monocytes associated with adhesions
5) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.81 Pain Relevance 0.08
Expression of CD62L by PMNs and monocytes were elevated in the NS group across all sample times relative to control, whereas HSD treatment significantly down-regulated CD62L expression at all time points.
Positive_regulation (elevated) of Gene_expression (expression) of CD62L in monocytes
6) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.28 Pain Relevance 0
After conventional crystalloid resuscitation, we found that relative to healthy controls, brain-injured patients exhibit extensive leukocyte mobilization, with significantly enhanced PMN and monocyte surface expression of L-selectin (CD62L) and ?
Positive_regulation (enhanced) of Gene_expression (expression) of CD62L in brain
7) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.21 Pain Relevance 0.06
Consistent with these findings, studies in humans and animals demonstrate upregulated cell-surface CD62L and CD11b expression on leukocytes following polytrauma and isolated head-injury [57].
Positive_regulation (upregulated) of Gene_expression (expression) of CD62L in leukocytes associated with injury
8) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.13 Pain Relevance 0.14
Herein we show that f-MLP and substance P induce rapid changes in neutrophil morphology, migration, and adhesion molecule expression, including upregulation of Mo1 (CD11b/CD18) and shedding of LAM-1 (also known as LECAM-1, Leu8, or TQ-1, the human homologue of murine gp100MEL14).
Positive_regulation (changes) of Gene_expression (shedding) of LAM-1 in neutrophil associated with adhesions and substance p
9) Confidence 0.43 Published 1991 Journal Blood Section Abstract Doc Link 1717072 Disease Relevance 0.41 Pain Relevance 0.29
Surprisingly, stimulation with TNFalpha, IFNgamma and IL-1beta also induced the expression of L-selectin on fetal and diabetic Schwann cells, but not on normal adult cells.
Neg (not) Positive_regulation (induced) of Gene_expression (expression) of L-selectin in Schwann cells associated with diabetes mellitus
10) Confidence 0.34 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10561528 Disease Relevance 0.72 Pain Relevance 0.37
T lymphocytes from labouring women showed significantly higher expression of CD26 (P < 0.001) and CD62L (P < 0.01) compared with non-labouring women.
Positive_regulation (higher) of Gene_expression (expression) of CD62L in T lymphocytes
11) Confidence 0.33 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.07 Pain Relevance 0
Neutrophils from labouring women showed a significantly higher surface expression of CD11a and CD11b (P = 0.001) and CD62L (P < 0.02) compared with the non-labouring women.
Positive_regulation (higher) of Gene_expression (expression) of CD62L in Neutrophils
12) Confidence 0.33 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0
Accordingly, there is a small, but significant, increase in circulating neutrophil L-selectin expression in smokers [7].
Positive_regulation (increase) of Gene_expression (expression) of L-selectin in neutrophil associated with nicotine addiction
13) Confidence 0.29 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.84 Pain Relevance 0.12
Accordingly, there is a small, but significant, increase in circulating neutrophil L-selectin expression in smokers [7].
Positive_regulation (increase) of Gene_expression (expression) of L-selectin in neutrophil associated with nicotine addiction
14) Confidence 0.29 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.84 Pain Relevance 0.12
In labouring women, we observed a significant increase in the proportion of monocytes expressing each of the cell surface markers CD64 (P < 0.01), CD11b (P < 0.001) and CD62L (P < 0.05) compared with monocytes from non-labouring women (Fig. 6A, B and C).
Positive_regulation (increase) of Gene_expression (expressing) of CD62L in monocytes
15) Confidence 0.22 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0 Pain Relevance 0
The elevated expression of antigen-presenting and co-stimulatory molecules, but reduced levels of CD62L, indicate a highly activated state for these eosinophils.
Positive_regulation (elevated) of Gene_expression (expression) of CD62L in eosinophils
16) Confidence 0.17 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.46 Pain Relevance 0
Thus increased expression of CD11b and decreased expression of CD62L by neutrophils and monocytes may play a central role as the mechanism by which leukocyte adhesion and consequently activation occurs following surgery [2], [21], [26].
Positive_regulation (increased) of in neutrophils Gene_expression (expression) of CD62L in monocytes associated with adhesions
17) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.81 Pain Relevance 0.08
TLR and/or FPR stimulation of neutrophils induce L-selectin shedding, enhanced CD11b expression and/or release of reactive oxygen species [28]–[31].
Positive_regulation (induce) of Gene_expression (shedding) of L-selectin in neutrophils
18) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.27 Pain Relevance 0.77
We studied the effect of atrial pacing induced myocardial ischemia on levels of soluble L-selectin (sL-selectin) and generation of neutrophil derived reactive oxygen species (ROS) in 10 patients with coronary artery disease (CAD) and stable angina and in six individuals without CAD.
Positive_regulation (induced) of Gene_expression (levels) of sL-selectin in neutrophil associated with angina, coronary artery disease and ischemia
19) Confidence 0.05 Published 2000 Journal Pacing Clin Electrophysiol Section Abstract Doc Link 10750129 Disease Relevance 0.84 Pain Relevance 0.22
Epinephrine also upregulates the surface expression of L-selectin on monocytes in vitro [25].
Positive_regulation (upregulates) of Gene_expression (expression) of L-selectin in monocytes
20) Confidence 0.04 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0.99 Pain Relevance 0.32

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