INT151790

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 1.09
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SNAP25) small molecule metabolic process (SNAP25) plasma membrane (SNAP25)
cytoplasm (SNAP25)
Anatomy Link Frequency
cleavage 2
neuronal 1
band 1
SNAP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 177 100.00 Very High Very High Very High
Pain 12 94.60 High High
imagery 2 89.52 High High
qutenza 3 85.68 High High
Calcitonin gene-related peptide 6 78.88 Quite High
Neurotransmitter 10 77.16 Quite High
Lasting pain 3 70.48 Quite High
Glutamate 1 68.56 Quite High
antagonist 19 66.56 Quite High
Nerve growth factor 1 64.16 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 95.84 Very High Very High Very High
Paralysis 3 95.12 Very High Very High Very High
Pain 13 94.60 High High
Increased Venous Pressure Under Development 8 93.16 High High
Overactive Bladder 4 90.64 High High
Urinary Tract Disease 1 87.32 High High
Nociception 8 76.04 Quite High
Gastroenteritis 6 50.32 Quite High
Virus Diseases 89 50.00 Quite Low
Borna Disease 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
experience of implementing SNAP risk factor management in routine practice (appropriateness, feasibility, client receptiveness, factors affecting implementation);

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SNAP Binding (management) of
1) Confidence 0.24 Published 2010 Journal BMC Nurs Section Body Doc Link PMC2841173 Disease Relevance 0 Pain Relevance 0
The provision of resources to support the implementation of the intervention including a written guide for nurses, written action plans for use with clients on each SNAP risk factor, tape measures for measuring waist circumference, and pedometers to loan out to clients to encourage self monitoring of incidental physical activity
SNAP Binding (use) of
2) Confidence 0.24 Published 2010 Journal BMC Nurs Section Body Doc Link PMC2841173 Disease Relevance 0 Pain Relevance 0
The identified Spiegelmer l-SUP-A-004 binds substance P with a dissociation constant of ?
l-SUP-A-004 Binding (binds) of associated with substance p
3) Confidence 0.23 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.15
The mirror-image configuration of SUP-A-004, the so-called Spiegelmer, has been shown to bind to naturally occurring l-substance P displaying a Kd of 40 nM and to inhibit (IC50 of 45 nM) l-substance P-mediated Ca2+ release in a cell culture assay.



SUP-A-004 Binding (bind) of associated with substance p
4) Confidence 0.20 Published 2005 Journal Nucleic Acids Research Section Abstract Doc Link PMC552970 Disease Relevance 0.19 Pain Relevance 0.35
Quantification of protein phosphorylation was carried out by measuring the intensity of fluorescence of the band corresponding to the phosphorylated protein normalized by ß-tubulin expression, due to inefficient stripping of phospho-MARCKS and phospho-SNAP-25 antibodies binding.
phospho-SNAP-25 Binding (binding) of in band
5) Confidence 0.20 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0 Pain Relevance 0.04
The dissociation constant of the Spiegelmer l-SUP-A-004•substance P complex was determined to be 40 ± 9 nM by ITC experiments (data from three independent measurements).
l-SUP-A-004 Binding (complex) of associated with substance p
6) Confidence 0.18 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.22
Nieuwlandt et al. (16) reported an RNA aptamer to substance P that was isolated after two consecutive selection schemes and eventually showed a Kd of 190 nM (at room temperature). l-SUP-A-004 not only binds to substance P but also inhibits substance P action in a relevant cell assay.
l-SUP-A-004 Binding (binds) of associated with substance p
7) Confidence 0.18 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.19
Hence, converging evidence continues to emerge for the sequential formation of complexes between the three SNAREs (SNAP-25, syntaxin and VAMP) and their regulatory proteins (complexins, Munc18), as well as for the Ca2+ triggering of membrane fusion/exocytosis via its sensor, synaptotagmin.
SNAP-25 Binding (complexes) of
8) Confidence 0.16 Published 2009 Journal Curr Opin Pharmacol Section Abstract Doc Link 19394272 Disease Relevance 0.15 Pain Relevance 0.09
The efficacy of /EA is attributable to removal of 26 C-terminal residues from SNAP-25, precluding formation of SDS-resistant SNARE complexes.
SNAP-25 Binding (formation) of
9) Confidence 0.08 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19369567 Disease Relevance 0.21 Pain Relevance 0.55
For example, each serotype has a unique protease cleavage site specificity within the SNARE complex, though often in shared targets with A and E recognizing SNAP-25, B, D, F and G recognizing VAMP and C recognizing both SNAP-25 and syntaxin.
SNAP-25 Binding (recognizing) of in cleavage
10) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809108 Disease Relevance 0 Pain Relevance 0
For example, each serotype has a unique protease cleavage site specificity within the SNARE complex, though often in shared targets with A and E recognizing SNAP-25, B, D, F and G recognizing VAMP and C recognizing both SNAP-25 and syntaxin.
SNAP-25 Binding (recognizing) of in cleavage
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809108 Disease Relevance 0.05 Pain Relevance 0
In the neuronal cytosol, BTX-A disrupts fusion of the acetylcholine-containing vesicle with the neuronal wall by cleaving the SNAP-25 protein in the synaptic fusion complex.
SNAP-25 protein Binding (cleaving) of in neuronal
12) Confidence 0.05 Published 2008 Journal Nature clinical practice. Urology Section Abstract Doc Link 18461049 Disease Relevance 0.50 Pain Relevance 0.14

General Comments

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