INT151793

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 36
Total Number 42
Disease Relevance 2.32
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT3) cytoskeleton organization (KRT3)
Anatomy Link Frequency
corneal epithelial cells 8
corneal epithelium 6
epithelial cells 5
cornea 2
RCE 1
KRT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 93 94.64 High High
Nerve growth factor 6 51.68 Quite High
anesthesia 64 34.40 Quite Low
dexamethasone 27 5.00 Very Low Very Low Very Low
medulla 21 5.00 Very Low Very Low Very Low
ketamine 9 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
cryotherapy 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 93 94.64 High High
Disease 74 90.56 High High
Syndrome 36 89.80 High High
Conjunctiva Disease 25 89.52 High High
Ichthyosis 3 88.92 High High
Targeted Disruption 62 78.08 Quite High
Injury 125 73.36 Quite High
Overdose 21 72.48 Quite High
Lifespan 1 63.52 Quite High
Infection 19 60.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Total RNA was isolated from primary sphere colonies, the adherent progeny of sphere colonies, and rabbit corneal epithelial cells before culture with a kit (Isogen; Nippon Gene, Tokyo, Japan) according to the manufacturer’s instructions, after which RT–PCR was done to investigate the expression of nestin, keratin-3, and glyceraldehyde-3-phosphate dehydrogenase (G3PDH) as a housekeeping gene.
Spec (investigate) Gene_expression (expression) of keratin-3 in corneal epithelial cells
1) Confidence 0.75 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927443 Disease Relevance 0 Pain Relevance 0.03
K3/K12: keratins of the corneal epithelium
Gene_expression (/) of K3 in corneal epithelium
2) Confidence 0.60 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.18 Pain Relevance 0
K3/K12: keratins of the corneal epithelium
Gene_expression (keratins) of K3 in corneal epithelium
3) Confidence 0.60 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.23 Pain Relevance 0
These keratins are expressed in all corneal epithelial cell layers, whereas in the limbus corneae only suprabasal cells are positive and the basally located corneal stem cells are K3/K12 negative (Schermer et al. 1986; Pitz and Moll 2002).
Gene_expression (positive) of K3 in corneal epithelial cell
4) Confidence 0.60 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.23 Pain Relevance 0
The presence of clusters of corneal progenitor cells in conjunctiva has been reported, and it is possible that the expression of K3 and K12 observed in this study could be due to the proliferation of corneal stem cells in conjunctiva [34].
Gene_expression (expression) of K3 in conjunctiva
5) Confidence 0.52 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
The expression of cytokeratin K3 was increased in zones furthest from the explant (p < 0.005).
Gene_expression (expression) of cytokeratin K3
6) Confidence 0.47 Published 2008 Journal Regenerative medicine Section Body Doc Link 18462056 Disease Relevance 0 Pain Relevance 0
In addition, the expression of DeltaNp63, ABCG2 (both putative positive LSC markers) and cytokeratin K3 (marker of corneal differentiation) were assessed using quantitative reverse transcription PCR (RT-PCR).
Gene_expression (expression) of cytokeratin K3
7) Confidence 0.47 Published 2008 Journal Regenerative medicine Section Body Doc Link 18462056 Disease Relevance 0 Pain Relevance 0
Our studies indicate that the three cultures express markers of stratified epithelia such as cytokeratin K3, K4, K13, K15, and connexin 43.
Gene_expression (express) of K3
8) Confidence 0.45 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0.07 Pain Relevance 0
Double staining showed the expression of CK3 to be the same as Group A.
Gene_expression (expression) of CK3
9) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2627808 Disease Relevance 0 Pain Relevance 0
To confirm and characterize these epithelial cells, we investigated the expression of CK3 by immunofluorescent staining.
Spec (investigated) Gene_expression (expression) of CK3 in epithelial cells
10) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2627808 Disease Relevance 0.15 Pain Relevance 0.05
The results showed a subset of Rb-MSCs rapidly differentiated into corneal epithelial cells and expressed CK3 as of day three.
Gene_expression (expressed) of CK3 in corneal epithelial cells
11) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2627808 Disease Relevance 0 Pain Relevance 0
As shown in Figure 3, expression of CK3 was observed in both groups.
Gene_expression (expression) of CK3
12) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2627808 Disease Relevance 0.15 Pain Relevance 0.05
After induced treatment, the expression of cytokeratin 3 (CK3) was observed by immunofluorescence and flow cytometric analysis.
Gene_expression (expression) of CK3
13) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2627808 Disease Relevance 0.07 Pain Relevance 0
FACS analyses showed expression of CK3 in differentiated Rb-MSCs was similar in both groups.
Gene_expression (expression) of CK3
14) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2627808 Disease Relevance 0 Pain Relevance 0
Keratin 3 protein was expressed in the cultured corneal limbal epithelial cells while vimentin expression was highest in the keratocytes.
Gene_expression (expressed) of Keratin 3 in epithelial cells
15) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2592998 Disease Relevance 0.05 Pain Relevance 0.03
The three cell types maintained their shape and specific molecule expression in cell-ACMP scaffolds such as keratin 3, vimentin, and aquaporin A (Figure 5D-F), which was the same as the three cultured cell types (Figure 5A-C).
Gene_expression (expression) of keratin 3
16) Confidence 0.36 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2592998 Disease Relevance 0 Pain Relevance 0
Interestingly, conjunctival cultures also expressed cytokeratin K3 and K12.
Gene_expression (expressed) of K3
17) Confidence 0.35 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
Both limbal and oral epithelial cells expressed cytokeratin K3, the marker for differentiated corneal epithelial cells (Figure 3A).
Gene_expression (expressed) of K3 in corneal epithelial cells
18) Confidence 0.35 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
RT–PCR analysis showed that cultured oral epithelial cells expressed markers of epithelial differentiation such as cytokeratin K3, K4, K13, K15 and connexin 43.
Gene_expression (expressed) of K3 in epithelial cells
19) Confidence 0.35 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
To determine the molecular phenotype of differentiated Rb-MSCs, the expression of CK3 (special proteins of corneal epithelial cells) was examined by confocal microscopy.
Gene_expression (expression) of CK3 in corneal epithelial cells
20) Confidence 0.35 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2627808 Disease Relevance 0 Pain Relevance 0

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