INT151815

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.87
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (RUNX1) nucleus (RUNX1) DNA binding (RUNX1)
transcription factor binding (RUNX1)
RUNX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 7 99.44 Very High Very High Very High
Enkephalin 1 96.20 Very High Very High Very High
Morphine 3 95.44 Very High Very High Very High
Opioid 4 92.36 High High
antagonist 1 87.40 High High
mu opioid receptor 2 81.96 Quite High
Kappa opioid receptor 1 40.72 Quite Low
opiate 1 35.84 Quite Low
alcohol 7 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Myeloid Leukemia 27 100.00 Very High Very High Very High
Leukemia 96 99.64 Very High Very High Very High
Precursor Cell Lymphoblastic Leukemia-lymphoma 56 94.40 High High
Colon Cancer 1 90.04 High High
Apoptosis 17 88.72 High High
Cancer 24 86.32 High High
Death 21 75.44 Quite High
Brain Tumor 1 51.52 Quite High
Sarcoma 1 50.04 Quite High
Toxicity 15 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More significantly, a recent study using both cell culture and mouse models demonstrated that oridonin displayed a great antitumor activity specifically in acute myeloid leukemia with the t(8;21) translocation between AML1 and ETO genes.
Localization (translocation) of AML1 associated with leukemia
1) Confidence 0.68 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.69 Pain Relevance 0
Furthermore, a mu-opioid receptor-enhanced green fluorescent protein-fusion protein was localized in membranes of Jurkat cells and internalized in response to [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin but not morphine.
Localization (localized) of protein-fusion protein associated with enkephalin, opioid receptor and morphine
2) Confidence 0.09 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18463202 Disease Relevance 0 Pain Relevance 0.81
During the first few years of life, the incidence rate of AML among African American children is approximately one-third the rate among Caucasian children; however, African American children ?
Localization (rate) of AML associated with acute myeloid leukemia
3) Confidence 0.02 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1817663 Disease Relevance 1.19 Pain Relevance 0

General Comments

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