INT151817

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.19
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry2) aging (P2ry2) plasma membrane (P2ry2)
embryo development (P2ry2) lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
hippocampus 2
microglia 2
P2ry2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 6 99.68 Very High Very High Very High
Neuropathic pain 6 98.00 Very High Very High Very High
Hippocampus 13 97.60 Very High Very High Very High
Lasting pain 2 94.24 High High
Peripheral nerve injury 1 75.00 Quite High
Central nervous system 13 73.52 Quite High
intrathecal 5 67.52 Quite High
antagonist 19 64.80 Quite High
Brush evoked pain 5 60.64 Quite High
Stimulus evoked pain 1 59.12 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 6 98.44 Very High Very High Very High
Neuropathic Pain 14 98.00 Very High Very High Very High
Pain 6 94.24 High High
Neurodegenerative Disease 13 79.04 Quite High
Death 5 60.24 Quite High
Hypersensitivity 1 58.72 Quite High
Syndrome 1 53.04 Quite High
Apoptosis 4 41.32 Quite Low
Targeted Disruption 7 10.16 Low Low
Disease 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that the level of P2Y(12)R mRNA expression was markedly increased in the spinal cord ipsilateral to the nerve injury and that this expression was highly restricted to ionized binding calcium adapter molecule 1-positive microglia.
Positive_regulation (increased) of Transcription (expression) of P2Y in microglia associated with nervous system injury and spinal cord
1) Confidence 0.21 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18463248 Disease Relevance 0.99 Pain Relevance 0.73
There was a marked decrease in the concentration of mRNA coding for P2Y1 receptors and upregulation of mRNA transcription coding for P2Y2 receptors in freshly isolated astrocytes of developing rat hippocampus [57].


Positive_regulation (upregulation) of Transcription (transcription) of P2Y2 in hippocampus associated with hippocampus
2) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.20 Pain Relevance 0.09

General Comments

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