INT151849

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.26
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10, IL8) extracellular region (IL10, IL8) intracellular (IL10, IL8)
signal transduction (IL8) cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
macrophages 3
epithelial cells 2
monocytes 1
IL10 (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 242 100.00 Very High Very High Very High
cytokine 144 100.00 Very High Very High Very High
rheumatoid arthritis 66 82.24 Quite High
Inflammatory mediators 51 79.08 Quite High
tolerance 1 56.16 Quite High
peptic ulcer disease 1 50.00 Quite Low
chemokine 35 5.00 Very Low Very Low Very Low
Inflammatory response 22 5.00 Very Low Very Low Very Low
Arthritis 21 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 307 100.00 Very High Very High Very High
Infection 29 92.48 High High
Otitis Media With Effusion 184 88.40 High High
Otitis Media 268 86.56 High High
Rheumatoid Arthritis 67 82.24 Quite High
Congenital Anomalies 1 74.32 Quite High
Disease 71 72.40 Quite High
Enteropathy 1 65.60 Quite High
Macrophage Activation Syndrome 10 65.12 Quite High
Autoimmune Disease 2 54.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies showed that IL10 inhibited IL8 expression and activation of nuclear factor kappa B induced by H. pylori in gastric epithelial cells, and enhanced H. pylori growth in a bacterial-cell co-culture model.
IL10 Negative_regulation (inhibited) of Gene_expression (expression) of IL8 in epithelial cells
1) Confidence 0.14 Published 2008 Journal Gut Section Body Doc Link 18467372 Disease Relevance 0 Pain Relevance 0
IL-4 and IL-10 cooperate to inhibit the production of inflammatory cytokines, including IL-6 and IL-866).
IL-10 Negative_regulation (inhibit) of Gene_expression (production) of IL-8 associated with inflammation and cytokine
2) Confidence 0.10 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012271 Disease Relevance 1.00 Pain Relevance 0.43
IL-10, being the key anti-inflammatory cytokine, inhibits monocytes/macrophages and the production of TNF, IL-1, IL-6 and IL-8 (84).
IL-10 Negative_regulation (inhibits) of Gene_expression (production) of IL-8 in macrophages associated with inflammation and cytokine
3) Confidence 0.00 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.13 Pain Relevance 0.55
IL-10, being the key anti-inflammatory cytokine, inhibits monocytes/macrophages and the production of TNF, IL-1, IL-6 and IL-8 (84).
IL-10 Negative_regulation (inhibits) of in monocytes Gene_expression (production) of IL-8 in macrophages associated with inflammation and cytokine
4) Confidence 0.00 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.13 Pain Relevance 0.55

General Comments

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