INT151855

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.39
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PON1) extracellular region (PON1) lipid metabolic process (PON1)
Anatomy Link Frequency
blood 2
PON1 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 9 89.60 High High
alcohol 7 79.20 Quite High
addiction 2 61.28 Quite High
imagery 1 49.84 Quite Low
potassium channel 1 6.44 Low Low
bradykinin 8 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hereditary Angioedema 63 99.22 Very High Very High Very High
Disorder Of Lipid Metabolism 15 92.52 High High
Disease 17 90.92 High High
Abdominal Pain 9 89.60 High High
Angioedema 22 88.80 High High
Vomiting 8 88.32 High High
Insulin Resistance 18 87.12 High High
Diarrhoea 4 86.96 High High
Atherosclerosis 36 82.12 Quite High
Hypersensitivity 7 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hereditary angioedema (HAE), a rare genetic disorder caused by a deficiency of the C1 esterase inhibitor, leads to an episodic, self-limiting increase in vascular permeability.
Negative_regulation (deficiency) of Negative_regulation (inhibitor) of esterase associated with hereditary angioedema
1) Confidence 0.38 Published 2008 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 18467921 Disease Relevance 0.80 Pain Relevance 0.15
The authors demonstrated a deficiency of C1 esterase inhibitor in the blood of these patients, although the extent of the deficiency was not able to be determined.
Negative_regulation (deficiency) of Negative_regulation (inhibitor) of esterase in blood
2) Confidence 0.02 Published 2010 Journal BMC Blood Disord Section Body Doc Link PMC2881905 Disease Relevance 0.97 Pain Relevance 0
Ethanol may also prevent inhibition of paraoxonase by lowering AGEs.


Spec (may) Negative_regulation (prevent) of Negative_regulation (inhibition) of paraoxonase
3) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993980 Disease Relevance 0.61 Pain Relevance 0.07

General Comments

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