INT15186

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Context Info
Confidence 0.51
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.26
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HRH2) signal transducer activity (HRH2)
HRH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 19 100.00 Very High Very High Very High
cocaine 292 98.68 Very High Very High Very High
cINOD 6 94.40 High High
Morphine 3 93.96 High High
aspirin 3 93.84 High High
peptic ulcer disease 3 75.00 Quite High
Inflammation 13 48.56 Quite Low
abdominal pain 2 12.64 Low Low
nud 1 9.84 Low Low
Central nervous system 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urticaria 2 96.00 Very High Very High Very High
Anaphylaxis 8 94.96 High High
Increased Venous Pressure Under Development 5 89.92 High High
Death 14 88.80 High High
Infection 3 88.80 High High
Disease 14 88.56 High High
Fever 7 82.72 Quite High
Exanthema 2 82.08 Quite High
Glycosuria 1 81.32 Quite High
Hematuria 1 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bedtime H2-receptor blockade is one such regimen.
Negative_regulation (blockade) of H2-receptor
1) Confidence 0.51 Published 1991 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 1888835 Disease Relevance 0.42 Pain Relevance 0.10
Roxatidine is a potent inhibitor of basal and stimulated gastric acid secretion in animals and humans and, like most other H2-receptor antagonists, has no anti-androgenic effects and does not interfere with the hepatic metabolism of other drugs.
Negative_regulation (inhibitor) of H2-receptor associated with antagonist
2) Confidence 0.43 Published 1991 Journal Drugs Section Abstract Doc Link 1717223 Disease Relevance 0.47 Pain Relevance 0.17
The imidazole structure of cimetidine rather than its H2-receptor blocking activity is primarily responsible for cimetidine-induced inhibition of hepatic drug metabolism.
Negative_regulation (blocking) of H2-receptor
3) Confidence 0.37 Published 1982 Journal Gastroenterology Section Abstract Doc Link 6118314 Disease Relevance 0 Pain Relevance 0.17
This reduction in hepatic drug metabolism could be due to cimetidine's intrinsic H2-receptor blocking activity.
Negative_regulation (blocking) of H2-receptor
4) Confidence 0.27 Published 1982 Journal Gastroenterology Section Abstract Doc Link 6118314 Disease Relevance 0 Pain Relevance 0.07
Ranitidine hydrochloride (ZantacĀ®), a histamine-2-receptor antagonist, is a widely used medication with an excellent safety record.
Negative_regulation (antagonist) of histamine-2-receptor associated with antagonist
5) Confidence 0.21 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2488348 Disease Relevance 0.44 Pain Relevance 0.05
For five days, he was treated with prednisone 20 mg twice daily, loratadine 10 mg daily as well as famotidine 20 mg twice daily for H2 receptor blockade.
Negative_regulation (blockade) of H2 receptor
6) Confidence 0.08 Published 2006 Journal BMC Clin Pharmacol Section Body Doc Link PMC1397863 Disease Relevance 0.71 Pain Relevance 0
The dose of cimetidine used to block the histamine H2 receptor in rodents is ?
Negative_regulation (block) of histamine H2 receptor
7) Confidence 0.06 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.14 Pain Relevance 0.23
The use of H2-receptor antagonists and/or proton pump inhibitors also did not lead to significant differences in the incidence of these events between risedronate and placebo groups.
Negative_regulation (inhibitors) of H2-receptor associated with antagonist
8) Confidence 0.02 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909499 Disease Relevance 0.09 Pain Relevance 0.19

General Comments

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