INT15187

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Context Info
Confidence 0.66
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 10.97
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf3) extracellular region (Csf3) enzyme binding (Csf3)
Anatomy Link Frequency
motoneurons 18
forebrain 4
neurons 2
CNS 2
neutrophils 2
Csf3 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 105 100.00 Very High Very High Very High
Sciatic nerve 225 99.48 Very High Very High Very High
Spinal cord 210 97.40 Very High Very High Very High
ischemia 15 97.20 Very High Very High Very High
imagery 15 91.92 High High
Pain 19 80.96 Quite High
iatrogenic 1 76.00 Quite High
Inflammation 30 58.24 Quite High
vincristine 12 55.04 Quite High
lumbar region 15 50.12 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 240 99.78 Very High Very High Very High
Neurodegenerative Disease 30 99.28 Very High Very High Very High
Neutropenia 233 98.96 Very High Very High Very High
Fever 27 98.96 Very High Very High Very High
Death 168 98.60 Very High Very High Very High
Cv General 4 Under Development 15 97.56 Very High Very High Very High
Apoptosis 315 97.24 Very High Very High Very High
Motor Neuron Diseases 270 96.60 Very High Very High Very High
Injury 30 93.40 High High
Myelodysplastic Syndromes 10 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We chose to use transgenic mice that overexpress G-CSF in the CNS as an endogenous "delivery system" to study effects of increased concentration of G-CSF on the lesioned motoneurons.
Positive_regulation (overexpress) of Gene_expression (overexpress) of G-CSF in motoneurons associated with targeted disruption and central nervous system
1) Confidence 0.66 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.74 Pain Relevance 0.26
CNS- targeted overexpression of G-CSF protects motoneurons against cell death in neonatal pups
Positive_regulation (overexpression) of Gene_expression (overexpression) of G-CSF in motoneurons associated with central nervous system and death
2) Confidence 0.66 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.79 Pain Relevance 0.28
Overexpression of G-CSF protects lumbar motoneurons to an extent that is comparable to many of the classic neurotrophic factors.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of G-CSF in motoneurons
3) Confidence 0.66 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.28 Pain Relevance 0.04
The expression of G-CSF receptor is induced by neurons under neurodegenerative conditions such as after cerebral ischemia or in ALS, presumably as an endogenous protective response [6,7].
Positive_regulation (induced) of Gene_expression (expression) of G-CSF in neurons associated with cv general 4 under development, ischemia, neurodegenerative disease and motor neuron diseases
4) Confidence 0.66 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.42 Pain Relevance 0.26
On top of a relative increase of motoneuron numbers following overexpression of G-CSF, we also noted an increase of about 100 ?
Positive_regulation (overexpression) of Gene_expression (overexpression) of G-CSF in motoneuron
5) Confidence 0.66 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.38 Pain Relevance 0.03
 ;-promoter directed G-CSF overexpression in the forebrain leads to a strong elevation of G-CSF levels in the neonatal brain and spinal cord (P9; 28.00 ± 11.60 vs 0.24 ± 0.23 pg/mg tissue protein; p < 0.05) (Figure 3).
Positive_regulation (leads) of Gene_expression (overexpression) of G-CSF in forebrain associated with spinal cord
6) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.25 Pain Relevance 0.26
Although we do not see significant effects on the number of contralateral motoneurons in the different transgenic crosses, there is an interesting trend (p = 0.1) towards more motoneurons contralaterally in the G-CSF overexpressors compared to littermates not transgenic for the CaMKII tta driver.
Positive_regulation (overexpressors) of Gene_expression (overexpressors) of G-CSF in motoneurons associated with targeted disruption
7) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.89 Pain Relevance 0.03
On the ipsilateral (axotomized) side, there was a downward shift in the mean size of the motoneurons in the littermates that did not overexpress G-CSF (wt and BEG -/T CaMK-/-).
Neg (not) Positive_regulation (overexpress) of Neg (not) Gene_expression (overexpress) of G-CSF in motoneurons
8) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.29 Pain Relevance 0.04
 ;-promoter directed G-CSF overexpression in the forebrain leads to a strong elevation of G-CSF levels in the neonatal brain and spinal cord (P9; 28.00 ± 11.60 vs 0.24 ± 0.23 pg/mg tissue protein; p < 0.05) (Figure 3).
Positive_regulation (overexpression) of Gene_expression (overexpression) of G-CSF in forebrain associated with spinal cord
9) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.25 Pain Relevance 0.25
On top of a relative increase of motoneuron numbers following overexpression of G-CSF, we also noted an increase of about 100 ?
Positive_regulation (increase) of Gene_expression (overexpression) of G-CSF in motoneuron
10) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.39 Pain Relevance 0.03
G-CSF preserves motoneuron size after axotomy
Positive_regulation (preserves) of Gene_expression (preserves) of G-CSF in motoneuron
11) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.41 Pain Relevance 0.07
For generating CNS- target G-CSF overexpressing mice, mice of line BEG6 were crossed with mice expressing the Tet-transactivator under control of the CaMKII-promoter (CaMKII-tta) [33], and successful activation of the construct was verified by EYFP imaging.


Positive_regulation (generating) of Gene_expression (overexpressing) of G-CSF associated with central nervous system and imagery
12) Confidence 0.45 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.56 Pain Relevance 0.23
We performed sciatic nerve axotomy in neonatal mice overexpressing G-CSF in the CNS and found that G-CSF transgenic mice displayed significantly higher numbers of surviving lumbar motoneurons 4 days following axotomy than their littermate controls.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of G-CSF in CNS associated with targeted disruption, central nervous system and sciatic nerve
13) Confidence 0.45 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2844381 Disease Relevance 1.14 Pain Relevance 0.22
This analysis revealed that only 50 - 60% of the motoneurons survived in the genotypes lacking the CaMK-tta driver transgene, whereas close to 90% of the motoneurons survived in the double transgenic mice (i.e. in animals overexpressing G-CSF) (BEG -/T CaMK-/T (88.76 ± 4.32%) vs.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of G-CSF in motoneurons associated with targeted disruption
14) Confidence 0.45 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.40 Pain Relevance 0.09
For generating CNS- target G-CSF overexpressing mice, mice of line BEG6 were crossed with mice expressing the Tet-transactivator under control of the CaMKII-promoter (CaMKII-tta) [33], and successful activation of the construct was verified by EYFP imaging.


Positive_regulation (overexpressing) of Gene_expression (overexpressing) of G-CSF associated with central nervous system and imagery
15) Confidence 0.45 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.56 Pain Relevance 0.23
The increase in neutrophils produced by rG-CSF renders it a useful treatment for conditions such as congenital, acquired and cyclic neutropenias for which current therapy is not very successful. rG-CSF may be an effective therapy in myelodysplasia, although there is concern about acceleration of the possible rate of conversion of this disease to acute myelogenous leukaemia.
Positive_regulation (increase) of Gene_expression (produced) of rG-CSF in neutrophils associated with neutropenia, acute myeloid leukemia, myelodysplastic syndromes and disease
16) Confidence 0.37 Published 1991 Journal Drugs Section Abstract Doc Link 1717226 Disease Relevance 0.89 Pain Relevance 0.12
Official guidelines from Europe and the USA now agree that primary G-CSF prophylaxis should be given when the overall risk of FN due to regimen and patient factors is ?
Positive_regulation (given) of Gene_expression (prophylaxis) of G-CSF associated with neutropenia
17) Confidence 0.21 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 0.89 Pain Relevance 0.03
G-CSF prophylaxis is now recommended when the overall risk of febrile neutropenia (FN) due to regimen and individual patient factors is ?
Positive_regulation (recommended) of Gene_expression (prophylaxis) of G-CSF associated with neutropenia and fever
18) Confidence 0.21 Published 2010 Journal Support Care Cancer Section Abstract Doc Link PMC2846279 Disease Relevance 0.57 Pain Relevance 0
Official guidelines from Europe and the USA now agree that primary G-CSF prophylaxis should be given when the overall risk of FN due to regimen and patient factors is ?
Positive_regulation (primary) of Gene_expression (prophylaxis) of G-CSF associated with neutropenia
19) Confidence 0.21 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 0.89 Pain Relevance 0.03

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