INT151877

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CAV2) mitochondrion organization (CAV2) intracellular (CAV2)
protein complex (CAV2) cytoplasm (CAV2) cytosol (CAV2)
Anatomy Link Frequency
external 2
CAV2 (Homo sapiens)
Pain Link Frequency Relevance Heat
vincristine 48 100.00 Very High Very High Very High
addiction 3 96.96 Very High Very High Very High
imagery 1 92.72 High High
Calcium channel 2 83.36 Quite High
intrathecal 1 75.84 Quite High
Pain 3 73.20 Quite High
Ziconotide 1 70.04 Quite High
Dorsal horn neuron 1 68.08 Quite High
Root ganglion neuron 1 67.12 Quite High
Potency 1 63.36 Quite High
Disease Link Frequency Relevance Heat
Lung Cancer 10 99.00 Very High Very High Very High
Pain 3 73.20 Quite High
Ganglion Cysts 1 66.80 Quite High
Disease 18 39.64 Quite Low
Small Cell Lung Cancer 30 5.00 Very Low Very Low Very Low
Recurrence 17 5.00 Very Low Very Low Very Low
Metastasis 11 5.00 Very Low Very Low Very Low
Toxicity 6 5.00 Very Low Very Low Very Low
Thrombocytopenia 6 5.00 Very Low Very Low Very Low
Neutropenia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stable cell lines expressing functional Cav2 channels (Ca(V)alpha, beta(3), and alpha(2)delta subunits) were co-transfected with an inward rectifier (Kir2.3) so that membrane potential, and therefore channel state, could be controlled by external potassium concentration.
Positive_regulation (co-transfected) of Gene_expression (expressing) of Cav2 in external
1) Confidence 0.40 Published 2008 Journal Assay Drug Dev Technol Section Abstract Doc Link 18471074 Disease Relevance 0.20 Pain Relevance 0.56
Intravenous topotecan versus CAV
Positive_regulation (versus) of Gene_expression (versus) of CAV associated with vincristine
2) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2931489 Disease Relevance 0.19 Pain Relevance 0.16

General Comments

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