INT151878

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Context Info
Confidence 0.66
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 9.26
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CAV2) mitochondrion organization (CAV2) intracellular (CAV2)
protein complex (CAV2) cytoplasm (CAV2) cytosol (CAV2)
Anatomy Link Frequency
external 2
muscle 1
pore 1
cerebellum 1
CAV2 (Homo sapiens)
Pain Link Frequency Relevance Heat
vincristine 48 100.00 Very High Very High Very High
nav1.3 1 99.96 Very High Very High Very High
nav1.8 1 99.80 Very High Very High Very High
Nav1.7 1 99.64 Very High Very High Very High
Neuropathic pain 4 99.24 Very High Very High Very High
Neuropeptide 1 98.88 Very High Very High Very High
Neurotransmitter 8 98.16 Very High Very High Very High
hyperexcitability 1 97.12 Very High Very High Very High
addiction 6 96.96 Very High Very High Very High
Calcium channel 88 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Mouth Disease 585 100.00 Very High Very High Very High
Disease 142 99.32 Very High Very High Very High
Neuropathic Pain 4 99.24 Very High Very High Very High
Lung Cancer 10 99.00 Very High Very High Very High
Cytomegalovirus Infection 54 96.56 Very High Very High Very High
Common Cold 18 96.20 Very High Very High Very High
Cerebellar Diseases 1 95.88 Very High Very High Very High
Enterovirus Infection 117 95.40 Very High Very High Very High
Headache 37 94.64 High High
Epilepsy 1 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stable cell lines expressing functional Cav2 channels (Ca(V)alpha, beta(3), and alpha(2)delta subunits) were co-transfected with an inward rectifier (Kir2.3) so that membrane potential, and therefore channel state, could be controlled by external potassium concentration.
Gene_expression (expressing) of Cav2 in external
1) Confidence 0.66 Published 2008 Journal Assay Drug Dev Technol Section Abstract Doc Link 18471074 Disease Relevance 0.20 Pain Relevance 0.55
Glass coverslips carrying cells expressing mutant or WT Cav2.2 channels were transferred to a 3.5-cm culture dish (Corning) containing external recording solution consisting of 20 mM BaCl2, 1 mM MgCl2, 10 mM HEPES, 40 mM TEA-Cl, 10 mM glucose, and 65 mM CsCl (pH 7.2 adjusted with TEA-OH).
Gene_expression (expressing) of Cav2 in external
2) Confidence 0.62 Published 2010 Journal Mol Brain Section Body Doc Link PMC2829547 Disease Relevance 0 Pain Relevance 0.04
The impact of single amino acid substitutions on G protein inhibition is reminiscent of our earlier findings showing that phosphorylation of a single I-II linker residue, Thr422, can disrupt modulation of Cav2.2 channels by G?
Gene_expression (channels) of Cav2
3) Confidence 0.54 Published 2010 Journal Mol Brain Section Body Doc Link PMC2829547 Disease Relevance 0 Pain Relevance 0.04
This suggests that either other amino acid residues in the Cav2.2 ?
Spec (suggests) Gene_expression (suggests) of Cav2
4) Confidence 0.54 Published 2010 Journal Mol Brain Section Body Doc Link PMC2829547 Disease Relevance 0 Pain Relevance 0.06
The CACNA1A gene encoding Cav2.1 is highly expressed in the Purkinje cells of the cerebellum (32) and mutations in CACNA1A are responsible for a number of cerebellar disorders including migraine (33), epilepsy (34) and ataxias (35) but little is known about the transcriptional regulation of this gene.
Gene_expression (expressed) of Cav2 in cerebellum associated with epilepsy, cerebellar diseases, ataxia and migraine
5) Confidence 0.28 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0.38 Pain Relevance 0.31
Expression of caveolin-3 is muscle-specific, whereas caveolin-1 and caveolin-2 are coexpressed in many cell types [26].
Gene_expression (coexpressed) of caveolin-2 in muscle
6) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0.80 Pain Relevance 0.17
Intravenous topotecan versus CAV
Gene_expression (versus) of CAV associated with vincristine
7) Confidence 0.23 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2931489 Disease Relevance 0.19 Pain Relevance 0.16
OEC microarray data revealed high expression of VE-cadherin, claudin 11, claudin 5, caveolin 1 and caveolin 2 which was indicative of the presence of cell-cell specialized junctions and caveolae organelles.
Gene_expression (expression) of caveolin 2
8) Confidence 0.16 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0 Pain Relevance 0
Among the molecular drivers are ion channels (Nav1.7, Nav1.8, Nav1.3, Cav2.2, and alpha2-delta subunits) whose expression is changed during neuropathic pain and their block shows therapeutic utility.
Gene_expression (expression) of Cav2 associated with nav1.3, neuropathic pain, nav1.8 and nav1.7
9) Confidence 0.15 Published 2008 Journal Br J Anaesth Section Abstract Doc Link 18511441 Disease Relevance 0.44 Pain Relevance 0.70
Loss-of-function mutants in unc-2, the CaV2 pore-forming ?
Gene_expression (pore) of CaV2 in pore
10) Confidence 0.08 Published 2007 Journal Neural Develop Section Body Doc Link PMC2213652 Disease Relevance 0 Pain Relevance 0.15
Five cases of CAV16 were identified, as well as four cases each of CAV6, CAV24, and EV18; three cases of CAV10; and one case each of CAV4, CBV3, CBV4, and CBV5.
Gene_expression (each) of CAV6
11) Confidence 0.05 Published 2003 Journal Emerging Infectious Diseases Section Body Doc Link PMC2873753 Disease Relevance 0.91 Pain Relevance 0
Other viruses cultured in smaller numbers included CAV16, CAV4, CAV10, and CBV5, known etiologic agents of HFMD, as well as CAV6, CAV24, CBV3, CBV4, and EV18, cocirculating enteroviruses that may have caused at least some cases of HFMD.
Gene_expression (included) of CAV6 associated with mouth disease
12) Confidence 0.05 Published 2003 Journal Emerging Infectious Diseases Section Body Doc Link PMC2873753 Disease Relevance 0.78 Pain Relevance 0
However, the presence of dual viruses did not result in severe disease, although a child with HEV71 and CAV16 coinfection died in Singapore in 1997 (29).
Gene_expression (coinfection) of CAV16 associated with disease
13) Confidence 0.05 Published 2003 Journal Emerging Infectious Diseases Section Body Doc Link PMC2873753 Disease Relevance 0.69 Pain Relevance 0
Other viruses cultured in smaller numbers included CAV16, CAV4, CAV10, and CBV5, known etiologic agents of HFMD, as well as CAV6, CAV24, CBV3, CBV4, and EV18, cocirculating enteroviruses that may have caused at least some cases of HFMD.
Gene_expression (included) of CAV16 associated with mouth disease
14) Confidence 0.05 Published 2003 Journal Emerging Infectious Diseases Section Body Doc Link PMC2873753 Disease Relevance 0.77 Pain Relevance 0
Other viruses cultured in smaller numbers included CAV16, CAV4, CAV10, and CBV5, known etiologic agents of HFMD, as well as CAV6, CAV24, CBV3, CBV4, and EV18, cocirculating enteroviruses that may have caused at least some cases of HFMD.
Gene_expression (included) of CAV4 associated with mouth disease
15) Confidence 0.05 Published 2003 Journal Emerging Infectious Diseases Section Body Doc Link PMC2873753 Disease Relevance 0.77 Pain Relevance 0
Five cases of CAV16 were identified, as well as four cases each of CAV6, CAV24, and EV18; three cases of CAV10; and one case each of CAV4, CBV3, CBV4, and CBV5.
Gene_expression (cases) of CAV16
16) Confidence 0.05 Published 2003 Journal Emerging Infectious Diseases Section Body Doc Link PMC2873753 Disease Relevance 0.89 Pain Relevance 0
Other viruses cultured in smaller numbers included CAV16, CAV4, CAV10, and CBV5, known etiologic agents of HFMD, as well as CAV6, CAV24, CBV3, CBV4, and EV18, cocirculating enteroviruses that may have caused at least some cases of HFMD.
Gene_expression (included) of CAV10 associated with mouth disease
17) Confidence 0.05 Published 2003 Journal Emerging Infectious Diseases Section Body Doc Link PMC2873753 Disease Relevance 0.77 Pain Relevance 0
Five cases of CAV16 were identified, as well as four cases each of CAV6, CAV24, and EV18; three cases of CAV10; and one case each of CAV4, CBV3, CBV4, and CBV5.
Gene_expression (each) of CAV24
18) Confidence 0.05 Published 2003 Journal Emerging Infectious Diseases Section Body Doc Link PMC2873753 Disease Relevance 0.91 Pain Relevance 0
Other viruses cultured in smaller numbers included CAV16, CAV4, CAV10, and CBV5, known etiologic agents of HFMD, as well as CAV6, CAV24, CBV3, CBV4, and EV18, cocirculating enteroviruses that may have caused at least some cases of HFMD.
Gene_expression (included) of CAV24 associated with mouth disease
19) Confidence 0.02 Published 2003 Journal Emerging Infectious Diseases Section Body Doc Link PMC2873753 Disease Relevance 0.78 Pain Relevance 0

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