INT15189

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Context Info
Confidence 0.79
First Reported 1984
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 30
Disease Relevance 9.09
Pain Relevance 8.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
neurons 6
nerves 3
peripheral nervous systems 2
spinal cord 1
brain 1
Npy (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 94 100.00 Very High Very High Very High
substance P 27 100.00 Very High Very High Very High
Dynorphin 19 100.00 Very High Very High Very High
Hippocampus 13 99.98 Very High Very High Very High
Peripheral nervous system 5 99.96 Very High Very High Very High
Enkephalin 29 99.90 Very High Very High Very High
gABA 42 99.84 Very High Very High Very High
guanethidine 3 99.78 Very High Very High Very High
Somatostatin 31 99.72 Very High Very High Very High
Fibrositis 10 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sleep Disorders 10 99.72 Very High Very High Very High
Stress 180 99.64 Very High Very High Very High
Chronic Fatigue Syndrome 380 99.24 Very High Very High Very High
Aids-related Complex 24 99.12 Very High Very High Very High
Panic Disorder 5 98.04 Very High Very High Very High
Congenital Anomalies 21 95.92 Very High Very High Very High
Targeted Disruption 60 94.64 High High
Systemic Lupus Erythematosus 10 94.20 High High
Hyperphagia 12 93.80 High High
Rheumatoid Arthritis 10 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuropeptide Y (NPY) is found in both the central and peripheral nervous systems.
Localization (found) of Neuropeptide Y in peripheral nervous systems associated with neuropeptide
1) Confidence 0.79 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3024290 Disease Relevance 1.52 Pain Relevance 0.18
In the peripheral nervous system, NPY is concentrated in and released from sympathetic nerve endings, either alone or with catecholamines.
Localization (released) of NPY in nerve associated with peripheral nervous system and catecholamine
2) Confidence 0.79 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3024290 Disease Relevance 1.49 Pain Relevance 0.21
Neuropeptide Y (NPY) is found in both the central and peripheral nervous systems.
Localization (found) of NPY in peripheral nervous systems associated with neuropeptide
3) Confidence 0.79 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3024290 Disease Relevance 1.51 Pain Relevance 0.18
NPY release follows stress such as strenuous exercise [26], panic disorders [27], and cold exposure [28].
Localization (release) of NPY associated with panic disorder and stress
4) Confidence 0.79 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3024290 Disease Relevance 1.34 Pain Relevance 0.28
The marked increase in stereotypic activity and enhanced recovery from anesthetic suggest that blocking endogenous NPY released the brain areas from inhibitory control.
Localization (released) of NPY in brain
5) Confidence 0.71 Published 1994 Journal Peptides Section Abstract Doc Link 7937334 Disease Relevance 0 Pain Relevance 0.33
Pretreatment with prazosin or haloperidol affected neither the release of NPY nor the morphologic changes; pretreatment with tetrodotoxin and guanethidine abolished NPY release and prevented the PTX-B-induced morphologic changes.
Neg (neither) Localization (release) of NPY associated with tetrodotoxin and guanethidine
6) Confidence 0.70 Published 1999 Journal Peptides Section Abstract Doc Link 10477080 Disease Relevance 0 Pain Relevance 0.38
Neuropeptide Y release by pumiliotoxin-B in the electrically-stimulated mouse vas deferens: an immunohistochemical study.
Localization (release) of Neuropeptide Y in vas deferens associated with neuropeptide
7) Confidence 0.70 Published 1999 Journal Peptides Section Title Doc Link 10477080 Disease Relevance 0 Pain Relevance 0.30
Anatomical and functional studies have shown that Y1 receptors are targeted to basolateral epithelial membranes (Mannon et al., 1999; Cox and Tough, 2002) and would therefore be activated by endogenous PYY or NPY released into the subepithelial area.
Localization (released) of NPY
8) Confidence 0.69 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0 Pain Relevance 0.05
Neurons that release neuropeptide Y (NPY) have important effects on hypothalamic homeostatic regulation, including energy homeostasis, and innervate hypocretin neurons.
Localization (release) of neuropeptide Y in neurons associated with neuropeptide
9) Confidence 0.68 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15470140 Disease Relevance 0.07 Pain Relevance 0.31
Neurons that release neuropeptide Y (NPY) have important effects on hypothalamic homeostatic regulation, including energy homeostasis, and innervate hypocretin neurons.
Localization (release) of NPY in neurons associated with neuropeptide
10) Confidence 0.68 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15470140 Disease Relevance 0.07 Pain Relevance 0.31
The localization of the neuropeptide tyrosine (NPY) Y2 receptor (Y2R) protein was studied in mouse dorsal root ganglia (DRGs) and spinal cord, by using a recently developed rabbit anti-Y2R antibody and a sensitive immunohistochemical method.
Localization (localization) of NPY in spinal cord associated with neuropeptide and spinal cord
11) Confidence 0.68 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 16025447 Disease Relevance 0 Pain Relevance 0.27
Pretreatment with prazosin or haloperidol affected neither the release of NPY nor the morphologic changes; pretreatment with tetrodotoxin and guanethidine abolished NPY release and prevented the PTX-B-induced morphologic changes.
Localization (release) of NPY associated with tetrodotoxin and guanethidine
12) Confidence 0.61 Published 1999 Journal Peptides Section Abstract Doc Link 10477080 Disease Relevance 0 Pain Relevance 0.39
However, an earlier study found lower NPY in 12 fibromyalgia cases [35]
Localization (found) of NPY associated with fibrositis
13) Confidence 0.60 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3024290 Disease Relevance 1.40 Pain Relevance 0.35
The application of immunocytochemistry at both light and electron microscopic levels has revealed neuropeptide tyrosine (NPY)-immunoreactive material to be localized to norepinephrine-containing endocrine cells in the adrenal medulla and also to varicose nerve fibers penetrating the adrenal cortex of several mammalian species, including horse, cat, rat, guinea pig and mouse.
Localization (localized) of NPY in adrenal cortex associated with medulla and neuropeptide
14) Confidence 0.60 Published 1984 Journal Endocrinology Section Abstract Doc Link 6368205 Disease Relevance 0 Pain Relevance 0.21
Correlative electron microscopic immunostaining has revealed that enkephalin and NPY immunoreactivities are co-localized to the same norepinephrine-containing secretory granules.
Localization (localized) of NPY associated with enkephalin
15) Confidence 0.60 Published 1984 Journal Endocrinology Section Abstract Doc Link 6368205 Disease Relevance 0 Pain Relevance 0.23
NPY neurons signal through a complex release of NPY, AgRP, and ?
Localization (release) of NPY in neurons
16) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0.09 Pain Relevance 0.15
After a meal, the gut releases PYY3–36 into the circulation, which crosses the BBB and reduces food intake by suppressing NPY release and increasing POMC release in the arcuate nucleus [77-80].
Localization (release) of NPY in gut
17) Confidence 0.50 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.28 Pain Relevance 0.08
This is achieved in part by altering the balance of neuronal activity, favouring NPY/AgRP release and reducing ?
Localization (release) of NPY in neuronal
18) Confidence 0.47 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.21 Pain Relevance 0.12
This suggests that POMC may normally inhibit NPY expression tonically in the DMH and that AgRP may be a determinant of NPY release physiologically [161].
Localization (release) of NPY
19) Confidence 0.47 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.06 Pain Relevance 0.10
Interestingly, CB1 activation stimulates NPY release [28] therefore a positive feed-back loop between endocannabinoids and ghrelin-induced NPY would partly explain the lack of effect in CB1-KO animals.
Localization (release) of NPY associated with endocannabinoid
20) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.38

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