INT151894

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1I2) small molecule metabolic process (CYP3A4) endoplasmic reticulum (CYP3A4)
enzyme binding (CYP3A4) lipid metabolic process (CYP3A4) cytoplasm (CYP3A4)
NR1I2 (Homo sapiens)
CYP3A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 1 81.72 Quite High
fluoxetine 1 80.36 Quite High
antidepressant 1 79.68 Quite High
Disease Link Frequency Relevance Heat
Toxicity 2 89.36 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 77.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The orphan nuclear receptor, pregnane X receptor (PXR), have been found to play a critical role in the induction of CYP3A4.
pregnane X receptor Positive_regulation (induction) of CYP3A4
1) Confidence 0.19 Published 2008 Journal Curr. Drug Metab. Section Abstract Doc Link 18473749 Disease Relevance 0.23 Pain Relevance 0.16

General Comments

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