INT151895

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP3A4, GBE1) transferase activity, transferring glycosyl groups (GBE1) endoplasmic reticulum (CYP3A4)
carbohydrate metabolic process (GBE1) enzyme binding (CYP3A4) lipid metabolic process (CYP3A4)
CYP3A4 (Homo sapiens)
GBE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 1 91.60 High High
fluoxetine 1 90.24 High High
antidepressant 1 89.56 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 87.24 High High
Toxicity 2 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many of these drugs are also mechanism-based inhibitors of CYP3A4, which involves formation of reactive metabolites, binding to CYP3A4 and irreversible enzyme inactivation.
CYP3A4 Binding (binding) of enzyme
1) Confidence 0.01 Published 2008 Journal Curr. Drug Metab. Section Abstract Doc Link 18473749 Disease Relevance 0.24 Pain Relevance 0.18

General Comments

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