INT15190

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Context Info
Confidence 0.61
First Reported 1991
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 5.33
Pain Relevance 5.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
hypothalamus 2
neurons 2
ileum 1
arcuate nucleus 1
nerve 1
Npy (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 67 100.00 Very High Very High Very High
GABAergic 14 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
antidepressant 3 100.00 Very High Very High Very High
Enkephalin 26 99.92 Very High Very High Very High
Somatostatin 17 99.92 Very High Very High Very High
narcan 1 99.00 Very High Very High Very High
Dorsal horn neuron 1 98.44 Very High Very High Very High
Inflammation 1 97.52 Very High Very High Very High
gABA 10 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Appetite Loss 15 100.00 Very High Very High Very High
Convulsion 78 99.92 Very High Very High Very High
Nervous System Injury 1 99.24 Very High Very High Very High
Obesity 77 98.90 Very High Very High Very High
Epilepsy 14 97.52 Very High Very High Very High
INFLAMMATION 1 97.52 Very High Very High Very High
Status Epilepticus 2 92.16 High High
Pain 3 90.00 High High
Anorexia 14 89.96 High High
Neurodegenerative Disease 54 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the spinal level galanin and NPY are regulated in DRG neurons by nerve injury and in dorsal horn neurons by inflammation.
Regulation (regulated) of NPY in neurons associated with nervous system injury, inflammation and dorsal horn neuron
1) Confidence 0.61 Published 1999 Journal Horm. Metab. Res. Section Abstract Doc Link 10422730 Disease Relevance 0.35 Pain Relevance 0.30
For example, the neuropeptide-rich hypothalamus region showed decreased (Met)enkephalin in PC2 deficient mice, but NPY, VIP, galanin, and CRF were not altered.
Neg (not) Regulation (altered) of NPY in hypothalamus associated with neuropeptide and enkephalin
2) Confidence 0.57 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12860111 Disease Relevance 0 Pain Relevance 0.74
Hypothalamic expression levels of peptides known to be involved in appetite regulation, such as NPY, POMC, and AGRP, are changed upon food deprivation, and neurons expressing these molecules are essential components in the control of energy homeostasis [8].
Regulation (regulation) of NPY in neurons associated with appetite loss
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 1.27 Pain Relevance 0
Taken together, these results suggest a role for 5-HT-related systems in the antidepressant-like properties of NPY.
Regulation (role) of NPY associated with antidepressant
4) Confidence 0.45 Published 2005 Journal Peptides Section Abstract Doc Link 16042979 Disease Relevance 0 Pain Relevance 0.59
Of the genes with changed expression levels in fasted adults, only Npy was affected in food deprived mouse pups.
Regulation (affected) of Npy
5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 1.06 Pain Relevance 0
Plasticity in expression of immunoreactivity for neuropeptide Y, enkephalins and neurotensin in the hypothalamic tubero-infundibular dopaminergic system during lactation in mice.
Regulation (immunoreactivity) of neuropeptide Y associated with neuropeptide and enkephalin
6) Confidence 0.38 Published 1993 Journal J. Neuroendocrinol. Section Title Doc Link 8680430 Disease Relevance 0.07 Pain Relevance 0.76
Neuropeptide Y (NPY) is a multifunctional peptide that is expressed in GABAergic interneurons, regulates pre-synaptic excitatory transmission in the DG, and has anti-epileptic properties [36].
Regulation (regulates) of Neuropeptide Y in interneurons associated with epilepsy, gabaergic and neuropeptide
7) Confidence 0.35 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 1.06 Pain Relevance 0.19
Adrenalectomy also blocked the effects of fasting on hypothalamic NPY mRNA (Fig. 2C), confirming the findings of Ponsalle et al. [14].
Regulation (effects) of NPY
8) Confidence 0.33 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.21 Pain Relevance 0
However, in one key respect the results reported by Savontaus et al. differed from those in the present paper: adrenalectomy failed to block the effects of fasting on hypothalamic AGRP and NPY, even though corticosterone implants were observed to induce AGRP mRNA.
Regulation (effects) of NPY
9) Confidence 0.33 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.26 Pain Relevance 0
However, in ob/ob mice (who congenitally lack leptin, leading to obesity), leptin deficiency exaggerates the direct inhibitory effect of NPY neurones on POMC neurones in the arcuate nucleus, an effect independent of the actions of GABA [64].
Regulation (effect) of NPY in arcuate nucleus associated with gaba and obesity
10) Confidence 0.28 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.60 Pain Relevance 0.42
This L-arginine effect on NPY activity was reversed by L-NMA (3 mM), and not by NG-methyl-D-arginine (10 mM).
Regulation (effect) of NPY
11) Confidence 0.27 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8764351 Disease Relevance 0 Pain Relevance 0.08
The L-arginine effect on NPY activity was concentration-related with an A50 (95% CL) value of 1.6 (0.9-2.3) mM.
Regulation (effect) of NPY
12) Confidence 0.27 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8764351 Disease Relevance 0 Pain Relevance 0.08
For example, NPY levels were decreased in ileum of PC2 deficient mice, but NPY content was not altered in hypothalamus that is abundant in NPY.
Neg (not) Regulation (altered) of NPY in hypothalamus
13) Confidence 0.25 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12860111 Disease Relevance 0 Pain Relevance 0.92
Nitric oxide modulates neuropeptide Y regulation of ion transport in mouse ileum.
Regulation (regulation) of neuropeptide Y in ileum associated with neuropeptide
14) Confidence 0.24 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8764351 Disease Relevance 0 Pain Relevance 0.10
In contrast, sulpiride, SCH-23390, naloxone, yohimbine and prazosin failed to antagonize the effects of NPY or JO 1784.
Regulation (effects) of NPY associated with narcan
15) Confidence 0.24 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8450462 Disease Relevance 0 Pain Relevance 0.24
In 2 of these SurvivinCamcre mice, we furthermore observed ectopic NPY immunoreactivity in the supragranular layer, likely reflecting sprouting of mossy fibers (not shown).
Regulation (immunoreactivity) of NPY in mossy fibers
16) Confidence 0.21 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.45 Pain Relevance 0.06
The absence of active PC2 resulted in altered cellular levels of NPY, somatostatin-28, and (Met)enkephalin; few changes in VIP or galanin occurred in the tissues examined.
Regulation (altered) of NPY associated with somatostatin and enkephalin
17) Confidence 0.11 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12860111 Disease Relevance 0 Pain Relevance 0.79
Immunoreactivity of SP, CGRP, VIP, and NPY was found in the nerve fibers distributed in the intervascular stroma of the carotid labyrinth.
Regulation (Immunoreactivity) of NPY in nerve associated with substance p
18) Confidence 0.08 Published 1991 Journal Histochemistry Section Abstract Doc Link 1717415 Disease Relevance 0 Pain Relevance 0.59

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