INT151904

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 8.07
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ager) plasma membrane (Ager) cytoplasm (Ager)
Anatomy Link Frequency
carotid artery 2
nerve 1
Ager (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 1 90.40 High High
anesthesia 1 89.44 High High
diabetic neuropathy 8 86.24 High High
Inflammation 12 82.64 Quite High
Demyelination 1 63.60 Quite High
peripheral neuropathy 2 45.40 Quite Low
aspirin 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 288 99.80 Very High Very High Very High
Insulin Resistance 2 99.32 Very High Very High Very High
Diabetes Mellitus 205 99.04 Very High Very High Very High
Injury 14 98.76 Very High Very High Very High
Hyperglycemia 13 98.68 Very High Very High Very High
Nervous System Injury 1 97.04 Very High Very High Very High
Obesity 14 96.44 Very High Very High Very High
Metabolic Syndrome 6 95.36 Very High Very High Very High
Disease 8 94.54 High High
Vasculitis 9 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zhou et al. demonstrated significantly increased accumulation of AGEs and increased immunoreactivities of RAGE and S100/calgranulins in the carotid artery of diabetic rats in response to balloon injury, as compared with that of nondiabetic rats.4 Blockage of the RAGE/ligand interaction significantly attenuated S100-stimulated vascular smooth muscle cell (VSMC) proliferation in vitro and bromodeoxyuridine (BrdU)-labeled proliferating VSMC in vivo, and suppressed neointimal formation and increased luminal areas in Zucker rats, both diabetic and nondiabetic.3 These findings indicate that RAGE/ligand interaction plays a key role in neointimal formation after PCI, especially in diabetics, and also suggest the plausibility of RAGE blockade as a therapeutic target in vascular injury, both in euglycemia and diabetes.
RAGE Binding (interaction) of in carotid artery associated with diabetes mellitus, injury and vasculitis
1) Confidence 0.18 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2823061 Disease Relevance 0.84 Pain Relevance 0.03
Zhou et al. demonstrated significantly increased accumulation of AGEs and increased immunoreactivities of RAGE and S100/calgranulins in the carotid artery of diabetic rats in response to balloon injury, as compared with that of nondiabetic rats.4 Blockage of the RAGE/ligand interaction significantly attenuated S100-stimulated vascular smooth muscle cell (VSMC) proliferation in vitro and bromodeoxyuridine (BrdU)-labeled proliferating VSMC in vivo, and suppressed neointimal formation and increased luminal areas in Zucker rats, both diabetic and nondiabetic.3 These findings indicate that RAGE/ligand interaction plays a key role in neointimal formation after PCI, especially in diabetics, and also suggest the plausibility of RAGE blockade as a therapeutic target in vascular injury, both in euglycemia and diabetes.
RAGE Binding (interaction) of in carotid artery associated with diabetes mellitus, injury and vasculitis
2) Confidence 0.13 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2823061 Disease Relevance 0.96 Pain Relevance 0.04
Diabetes is closely associated with macrovascular disease.11 Its possible mechanism may involve elevated levels of glucose, resulting in long-term "memory" in the vessel wall, thereby augmenting vascular perturbations.12 A recent report asserted that hyperglycemia leads to the generation and accumulation of AGEs, and that their interaction with the receptor for AGE (RAGE) involves the plausible mechanism of induction of vessel wall memory and sustained perturbation.
RAGE Binding (interaction) of associated with hyperglycemia, diabetes mellitus and disease
3) Confidence 0.13 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2823061 Disease Relevance 1.43 Pain Relevance 0
Of note, esRAGE levels are inversely associated to all these parameters each of which being in turn are related to ED.
esRAGE Binding (associated) of associated with reprotox - general 2
4) Confidence 0.11 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.54 Pain Relevance 0
There are at least three theoretical reasons whereby esRAGE could act as a biomarker for ED.
esRAGE Binding (biomarker) of associated with reprotox - general 2
5) Confidence 0.11 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 2.20 Pain Relevance 0.06
Although new drugs that inhibit the formation of AGEs and block the AGE-RAGE interaction are being studied, no effective treatment modalities against AGE-induced nerve injury are currently available clinically.
AGE-RAGE Binding (interaction) of in nerve associated with nervous system injury
6) Confidence 0.00 Published 2008 Journal Curr. Pharm. Des. Section Abstract Doc Link 18473845 Disease Relevance 1.11 Pain Relevance 0.46

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