INT151906

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.11
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.98
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Nfasc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
diabetic neuropathy 8 98.84 Very High Very High Very High
dorsal root ganglion 23 98.00 Very High Very High Very High
anesthesia 1 97.80 Very High Very High Very High
chemokine 6 97.36 Very High Very High Very High
Pain 11 96.24 Very High Very High Very High
Lasting pain 3 94.12 High High
Inflammatory mediators 1 85.92 High High
Demyelination 1 80.00 Quite High
peripheral neuropathy 2 61.80 Quite High
addiction 10 19.68 Low Low
Disease Link Frequency Relevance Heat
Stress 2 99.96 Very High Very High Very High
Diabetic Neuropathy 8 98.84 Very High Very High Very High
Ganglion Cysts 23 98.00 Very High Very High Very High
Pain 14 96.24 Very High Very High Very High
Diabetes Mellitus 2 95.20 Very High Very High Very High
INFLAMMATION 18 85.92 High High
Frailty 1 85.12 High High
Demyelinating Disease 1 80.00 Quite High
Hyperglycemia 1 71.16 Quite High
Amputation 1 66.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This upregulation required protein synthesis and activation of NF-?
Positive_regulation (required) of Positive_regulation (activation) of NF
1) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2698898 Disease Relevance 0.47 Pain Relevance 0.42
This suggests that, in diabetic neuropathy, AGEs and AGE/RAGE interactions induce oxidative stress, result in upregulation of nuclear factor (NF)-kappaB and various NF-kappaB-mediated proinflammatory genes, and exaggerate neurological dysfunction, including altered pain sensation.
Positive_regulation (result) of Positive_regulation (upregulation) of NF associated with stress, pain, anesthesia and diabetic neuropathy
2) Confidence 0.02 Published 2008 Journal Curr. Pharm. Des. Section Abstract Doc Link 18473845 Disease Relevance 1.51 Pain Relevance 0.55

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox