INT151907

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.48
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Ecm1) signal transducer activity (Ecm1) extracellular space (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Anatomy Link Frequency
Nerve 1
peripheral nerve 1
anterior pituitary 1
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
diabetic neuropathy 8 97.92 Very High Very High Very High
Demyelination 1 96.46 Very High Very High Very High
metalloproteinase 14 92.72 High High
Mechanotransduction 4 83.48 Quite High
chemokine 6 82.60 Quite High
cytokine 31 81.96 Quite High
Sciatic nerve 19 76.80 Quite High
peripheral neuropathy 2 74.72 Quite High
anesthesia 1 67.68 Quite High
Pain 4 64.16 Quite High
Disease Link Frequency Relevance Heat
Frailty 1 99.02 Very High Very High Very High
Diabetic Neuropathy 8 97.92 Very High Very High Very High
Demyelinating Disease 1 96.46 Very High Very High Very High
Adhesions 20 95.12 Very High Very High Very High
Cancer 25 94.20 High High
Hyperglycemia 1 92.04 High High
Diabetes Mellitus 3 87.68 High High
Prolactinoma 2 82.48 Quite High
Pituitary Cancer 11 81.32 Quite High
Amputation 1 79.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When cells bind to the ECM, integrins begin to cluster, which leads to the recruitment of structural and signaling proteins to form so-called focal adhesions at the site of integrin clustering.
ECM Binding (bind) of associated with adhesions
1) Confidence 0.11 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2687114 Disease Relevance 0.36 Pain Relevance 0.08
Furthermore, ECM proteins such as collagens, glycosaminoglycans, and proteoglycans provide instructive messages to cells that are transmitted across the cell membrane via the transmembrane receptors that recognize these ECM proteins.
ECM Binding (recognize) of
2) Confidence 0.11 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2687114 Disease Relevance 0 Pain Relevance 0.08
Basic Cap, by affecting microtubules assembly, can modify the cytoskeleton of the cells, and indirectly, the associated ECM [27,28].
ECM Binding (associated) of
3) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0
Nerve regeneration requires a complex interplay between cells, ECM, and growth factors.
ECM Binding (interplay) of in Nerve
4) Confidence 0.04 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2829579 Disease Relevance 0 Pain Relevance 0.04
Another important protein expressed in the anterior pituitary with a potential role in modifying paracrinicity by interaction with the ECM is connective tissue growth factor (CTGF) (827).
ECM Binding (interaction) of in anterior pituitary
5) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.65 Pain Relevance 0.13
Although the precise mechanisms underlying diabetic neuropathy remain unclear, there is evidence that hyperglycemia-induced formation of advanced glycation end products (AGEs) is related to diabetic neuropathy; AGE-modified peripheral nerve myelin is susceptible to phagocytosis by macrophages and contributes to segmental demyelination; modification of major axonal cytoskeletal proteins such as tubulin, neurofilament, and actin by AGEs results in axonal atrophy/degeneration and impaired axonal transport; and glycation of extracellular matrix protein laminin leads to impaired regenerative activity in diabetic neuropathy.
extracellular matrix protein Binding (glycation) of in peripheral nerve associated with hyperglycemia, demyelination, diabetic neuropathy and frailty
6) Confidence 0.01 Published 2008 Journal Curr. Pharm. Des. Section Abstract Doc Link 18473845 Disease Relevance 1.46 Pain Relevance 0.51

General Comments

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