INT151942

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2008
Negated 0
Speculated 3
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.41
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
spinal 2
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 295 99.84 Very High Very High Very High
Neuropeptide 1 99.82 Very High Very High Very High
spinal dorsal horn 1 94.16 High High
Pyramidal cell 9 92.96 High High
depression 101 88.36 High High
antagonist 57 87.32 High High
intrathecal 2 70.28 Quite High
agonist 3 62.60 Quite High
Hippocampus 33 54.04 Quite High
Calcium channel 3 50.12 Quite High
Disease Link Frequency Relevance Heat
Depression 101 88.36 High High
Stress Incontinence 2 80.64 Quite High
Anaerobic Bacterial Infections 12 51.72 Quite High
Anxiety Disorder 141 50.00 Quite Low
Attention Deficit Hyperactivity Disorder 1 42.36 Quite Low
Pain 4 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 2 5.00 Very Low Very Low Very Low
Overweight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, there is such a possibility, although remains to be demosntrated, that inhibition of NR2B-NMDARs affect the charge transfer during LTP induction.
Regulation (affect) of Negative_regulation (inhibition) of NR2B-NMDARs associated with long-term potentiation
1) Confidence 0.41 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.05 Pain Relevance 0.53
Next, we examined the effect of NR2B inhibition on LTP induced by pairing protocol (Figure 2A).
Spec (examined) Regulation (effect) of Spec (examined) Negative_regulation (inhibition) of NR2B associated with long-term potentiation
2) Confidence 0.41 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.44
We then investigated the effect of NR2B-NMDAR blockade on LTP induced by HFS using in vitro field-potential recordings.
Spec (investigated) Regulation (effect) of Spec (investigated) Negative_regulation (blockade) of NR2B-NMDAR associated with long-term potentiation
3) Confidence 0.41 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.43
Orexin-A modulates glutamatergic NMDA-dependent spinal reflex potentiation via inhibition of NR2B subunit.
Regulation (modulates) of Negative_regulation (inhibition) of NR2B in spinal associated with neuropeptide
4) Confidence 0.35 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Title Doc Link 18477704 Disease Relevance 0.08 Pain Relevance 0.28
In the present case we studied depotentiation induced by application of NMDA and examined its sensitivity to NR2A and NR2B inhibitors, since not much attention has been paid to this issue previously.
Spec (examined) Regulation (sensitivity) of Spec (examined) Negative_regulation (inhibitors) of NR2B
5) Confidence 0.33 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.28 Pain Relevance 0.24

General Comments

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