INT151943

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.55
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (UCN2) extracellular space (UCN2) extracellular region (UCN2)
response to stress (UCN2)
UCN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 4 99.84 Very High Very High Very High
agonist 1 99.20 Very High Very High Very High
antagonist 7 96.36 Very High Very High Very High
gABA 1 86.80 High High
Action potential 1 76.44 Quite High
GABAergic 2 75.00 Quite High
central sensitization 1 72.32 Quite High
spinal dorsal horn 1 67.28 Quite High
Pain 1 53.92 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress Incontinence 7 80.36 Quite High
Attention Deficit Hyperactivity Disorder 1 66.80 Quite High
Overactive Bladder 1 64.08 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although there is, so far, no NR2A- and NR2B-specific agonist available, N-methyl-d-aspartate (NMDA) reversed the abolition on the RS-induced SRP caused by the co-administration of OxA and Co-101244 (30 nM, 10 mul; an NMDA NR2B subunit antagonist), but it did not reverse the abolition by the co-administration of OxA and PPPA (300 nM, 10 mul; an NMDA NR2A subunit antagonist).
Negative_regulation (reversed) of Positive_regulation (induced) of SRP associated with antagonist and agonist
1) Confidence 0.42 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18477704 Disease Relevance 0.21 Pain Relevance 0.41
Acute anal stretch using a mosquito clamp with a distance of 4 mm exhibited no effect, whereas distances of 8 mm attenuated and 12 mm abolished the repetitive stimulation-induced SRP.
Negative_regulation (abolished) of Positive_regulation (induced) of SRP
2) Confidence 0.42 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18632795 Disease Relevance 0.33 Pain Relevance 0.41

General Comments

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