INT15197

Context Info Confidence 0.34 First Reported 1984 Last Reported 2005 Negated 2 Speculated 0 Reported most in Abstract Documents 8 Total Number 8 Disease Relevance 2.66 Pain Relevance 2.69

extracellular space (Ifng) extracellular region (Ifng)

Anatomy Link Frequency spleen 4 T cells 4 natural killer cell 2 Ifng (Mus musculus)

Pain Link Frequency Relevance Heat cocaine 7 100.00 Morphine 6 100.00 Opioid 6 100.00 substance P 7 99.98 Analgesic 1 99.76 methotrexate 5 98.44 dexamethasone 5 98.34 cytokine 15 92.04 Enkephalin 8 88.00 Inflammation 6 85.52

Disease Link Frequency Relevance Heat Necrosis 2 100.00 Cancer 2 100.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 4 99.72 Murine Acquired Immunodeficiency Syndrome 1 99.48 Pseudomonas Infection 2 99.24 Infection 7 98.32 Leukemia 1 96.12 Disease 3 92.52 Aging 2 90.12 Arthritis 4 79.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Substance P regulates natural killer cell interferon-gamma production and resistance to Pseudomonas aeruginosa infection.

Regulation (regulates) of Gene_expression (production) of interferon-gamma in natural killer cell associated with pseudomonas infection, infection and substance p

1) Confidence 0.34 Published 2005 Journal Eur. J. Immunol. Section Title Doc Link 15832292 Disease Relevance 0.71 Pain Relevance 0.52

To this end, the effects of various opioid peptides on the production of IL-2, IL-4, IL-6, and interferon-gamma (IFN-gamma) by CD4+ T cells were determined.

Regulation (effects) of Gene_expression (production) of interferon-gamma in T cells associated with opioid

2) Confidence 0.32 Published 1994 Journal Lymphokine Cytokine Res. Section Abstract Doc Link 7914752 Disease Relevance 0 Pain Relevance 0.39

To this end, the effects of various opioid peptides on the production of IL-2, IL-4, IL-6, and interferon-gamma (IFN-gamma) by CD4+ T cells were determined.

Regulation (effects) of Gene_expression (production) of IFN-gamma in T cells associated with opioid

3) Confidence 0.32 Published 1994 Journal Lymphokine Cytokine Res. Section Abstract Doc Link 7914752 Disease Relevance 0 Pain Relevance 0.40

ACTH1-24, like ACTH1-39, has full steroidogenesis activity but also had no effect on IFN gamma production, which suggests a dissociation of the immunoregulatory and steroidogenic properties of ACTH1-39.

Neg (no) Regulation (effect) of Gene_expression (production) of IFN gamma

4) Confidence 0.31 Published 1984 Journal J. Immunol. Section Abstract Doc Link 6317743 Disease Relevance 0 Pain Relevance 0.07

Incubating spleen cells from untreated mice in concentrations of 16-epiestriol ranging from 1 mg/ml to 100 pg/ml did not alter profiles of IFN-gamma production, in contrast to the suppressive dose-response effects of hydrocortisone.

Neg (not) Regulation (alter) of Gene_expression (production) of IFN-gamma in spleen

5) Confidence 0.25 Published 1998 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 9858313 Disease Relevance 0.26 Pain Relevance 0.20

RESULTS: Met-enkephalin, YGG and YG modulated the in vitro production of IFN-gamma in a biphasic manner: stimulation at low doses and inhibition at high doses.

Regulation (modulated) of Gene_expression (production) of IFN-gamma

6) Confidence 0.24 Published 2005 Journal Neuroimmunomodulation Section Body Doc Link 16557034 Disease Relevance 0 Pain Relevance 0

Treatments with IND, DEX, MTX and AUR inhibited both Th1 and Th2 immune responses, although the inhibitory effects of these drugs on the antigen-specific IgG2a and IFN-gamma production appeared to be greater than those on IgG1 and IL-10 production.

Regulation (effects) of Gene_expression (production) of IFN-gamma associated with methotrexate and dexamethasone

7) Confidence 0.22 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.56 Pain Relevance 0.58

The effects of cocaine and morphine on gamma-interferon (IFN) and tumor necrosis factor (TNF) production in vivo and with isolated spleen cells were measured by a sandwich enzyme-linked immunosorbent assay (ELISA) method.

Regulation (effects) of Gene_expression (production) of gamma-interferon in spleen associated with necrosis, cancer, morphine and cocaine

8) Confidence 0.21 Published 1991 Journal J. Leukoc. Biol. Section Abstract Doc Link 1717622 Disease Relevance 1.14 Pain Relevance 0.54

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