INT151978

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.15
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Cys1) cilium (Cys1) molecular_function (Cys1)
biological_process (Cys1) cytoplasm (Cys1)
Cys1 (Mus musculus)
Pain Link Frequency Relevance Heat
abdominal pain 1 98.98 Very High Very High Very High
Peripheral nervous system 1 72.80 Quite High
dysesthesia 1 68.72 Quite High
peripheral neuropathy 1 67.36 Quite High
Pain 1 39.80 Quite Low
Angina 1 17.60 Low Low
Deep tissue 3 5.00 Very Low Very Low Very Low
epidural 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 24 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 15 100.00 Very High Very High Very High
Abdominal Pain 1 98.98 Very High Very High Very High
Diarrhoea 3 98.66 Very High Very High Very High
Hematuria 1 98.44 Very High Very High Very High
Encephalopathy 1 98.20 Very High Very High Very High
Cv Unclassified Under Development 49 97.96 Very High Very High Very High
Confusion 1 97.88 Very High Very High Very High
Bacteremia 74 97.70 Very High Very High Very High
Heart Rate Under Development 3 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the bacteremia/endocarditis trial 5 of 22 patients who received prior or concomitant HMG-CoA reductase inhibitors and daptomycin developed creatine phosphokinase (CPK) elevations of >500 U/L.
Negative_regulation (developed) of Positive_regulation (elevations) of CPK associated with disorders of creatine metabolism, bacteremia and cv unclassified under development
1) Confidence 0.41 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2374935 Disease Relevance 1.02 Pain Relevance 0.14
Coadministration of L-carnitine did not prevent the occurrence or severity of muscular toxicity and CPK elevation.


Negative_regulation (prevent) of Positive_regulation (elevation) of CPK associated with toxicity and disorders of creatine metabolism
2) Confidence 0.04 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2666889 Disease Relevance 1.35 Pain Relevance 0
In a patient with non-zoonotic CAP, the clinical and laboratory features in a patient with CAP pointing to the diagnosis of Legionnaires' disease include relative bradycardia, mental confusion/ encephalopathy, loose stools/diarrhea, abdominal pain, mild/transient increases in serum transaminases, decreased serum phosphorous, a highly elevated C-reactive protein (CRP), elevated creatinine phosphokinase (CPK), highly elevated serum ferritin levels, or microscopic hematuria.
Negative_regulation (decreased) of Positive_regulation (elevated) of CPK associated with heart rate under development, abdominal pain, diarrhoea, pneumonia, disease, hematuria, confusion and encephalopathy
3) Confidence 0.02 Published 2008 Journal Heart Lung Section Abstract Doc Link 18482636 Disease Relevance 1.78 Pain Relevance 0.10

General Comments

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