INT15198

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Context Info
Confidence 0.10
First Reported 1987
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.63
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
monocytes 4
facial nerve 2
macrophages 2
joint 2
nerve 2
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 69 100.00 Very High Very High Very High
cocaine 14 100.00 Very High Very High Very High
Morphine 12 100.00 Very High Very High Very High
Nerve growth factor 9 100.00 Very High Very High Very High
Arthritis 3 99.84 Very High Very High Very High
Hippocampus 25 99.72 Very High Very High Very High
antagonist 30 93.96 High High
B1 receptor 34 93.48 High High
substance P 4 92.56 High High
withdrawal 14 92.36 High High
Disease Link Frequency Relevance Heat
Cancer 176 100.00 Very High Very High Very High
Necrosis 11 100.00 Very High Very High Very High
Arthritis 6 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 99.72 Very High Very High Very High
Murine Acquired Immunodeficiency Syndrome 2 99.48 Very High Very High Very High
Metastasis 58 99.28 Very High Very High Very High
Glioblastoma 99 99.12 Very High Very High Very High
Targeted Disruption 48 98.96 Very High Very High Very High
Aging 4 98.88 Very High Very High Very High
Pancreatic Cancer 57 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of tumor necrosis factor and gamma interferon production by cocaine and morphine in aging mice infected with LP-BM5, a murine retrovirus.
Regulation (Modulation) of Gene_expression (production) of factor associated with necrosis, aging, cancer, morphine and cocaine
1) Confidence 0.10 Published 1991 Journal J. Leukoc. Biol. Section Title Doc Link 1717622 Disease Relevance 1.20 Pain Relevance 0.72
The effects of cocaine and morphine on gamma-interferon (IFN) and tumor necrosis factor (TNF) production in vivo and with isolated spleen cells were measured by a sandwich enzyme-linked immunosorbent assay (ELISA) method.
Regulation (effects) of Gene_expression (production) of factor in spleen associated with necrosis, cancer, morphine and cocaine
2) Confidence 0.08 Published 1991 Journal J. Leukoc. Biol. Section Abstract Doc Link 1717622 Disease Relevance 1.14 Pain Relevance 0.54
A transgenic mouse has been developed which, during development, over-expresses nerve growth factor under the control of a myelin basic protein promoter.
Regulation (under) of Gene_expression (expresses) of factor in nerve associated with targeted disruption and nerve growth factor
3) Confidence 0.06 Published 1999 Journal Neuroscience Section Abstract Doc Link 10199622 Disease Relevance 0.54 Pain Relevance 0.57
Associated with the arthritis is the development of cytotoxicity to mouse chondrocytes and, in some animals, of rheumatoid factor, immune deposits in joint tissues and kidneys, and the production of autoantibodies to mouse type II collagen.
Regulation (development) of Gene_expression (production) of rheumatoid factor in joint associated with arthritis
4) Confidence 0.05 Published 1987 Journal Arthritis Rheum. Section Abstract Doc Link 3566822 Disease Relevance 0.75 Pain Relevance 0.34
The separation of the rtTA2S-M2 and TRE expressing vectors might serve as a useful tool to specifically target certain cell types for expression of the desired key transcription factor.
Regulation (target) of Gene_expression (expression) of factor
5) Confidence 0.01 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.13 Pain Relevance 0.11
Altered expression of the Oct4 transcription factor
Regulation (Altered) of Gene_expression (expression) of factor
6) Confidence 0.01 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.07 Pain Relevance 0
The authors speculate that changes in trophic factor expression, well documented in the injured facial nerve lesion model (Moran and Graeber, 2004), have a role to play in conjunction with changes in NO levels (Sunico et al., 2005).
Regulation (changes) of Gene_expression (expression) of factor in facial nerve
7) Confidence 0.01 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2954441 Disease Relevance 0.15 Pain Relevance 0.21
Administration of SSR240612 also prevented an increase in number of activated microglial cells in mouse hippocampus, but did not affect a reduction in expression of mRNA for brain-derived neurotrophic factor.
Neg (not) Regulation (affect) of in brain Gene_expression (expression) of factor in microglial cells associated with hippocampus
8) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC3022820 Disease Relevance 0.59 Pain Relevance 0.45
The changes in cytokine and growth factor expression that occur after ELM GBM-M2 selection are similar to those that predict aggressive disease and poor patient outcome, demonstrating the similarity of cell lines to the scenario in patients.
Regulation (changes) of Gene_expression (expression) of factor in GBM associated with glioblastoma, disease, metastasis and cytokine
9) Confidence 0.01 Published 2008 Journal J Transl Med Section Body Doc Link PMC2645376 Disease Relevance 1.81 Pain Relevance 0.05
Since the oncologic strategies such as chemotherapy, radiotherapy, antihormonal modalities or the systemic use of monoclonal antibodies have not achieved a significant improvement in the survival of pancreatic cancer patients, great efforts have been undertaken in investigating new treatment approaches that, based on the specific molecular changes of growth factor expression, could lead to novel treatment concepts in the management of pancreatic cancer.


Regulation (changes) of Gene_expression (expression) of factor associated with pancreatic cancer
10) Confidence 0.00 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 1.26 Pain Relevance 0
The mechanism associated with EPO expression regulation and G-CSF in the present study may be similar to a previously described molecular mechanism involved in VEGF expression regulation and macrophage colony-stimulating factor (M-CSF) in cell monocytes and macrophages [29].
Regulation (regulation) of Gene_expression (expression) of factor in monocytes
11) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.33 Pain Relevance 0.12
The mechanism associated with EPO expression regulation and G-CSF in the present study may be similar to a previously described molecular mechanism involved in VEGF expression regulation and macrophage colony-stimulating factor (M-CSF) in cell monocytes and macrophages [29].
Regulation (involved) of in macrophage Gene_expression (expression) of factor in monocytes
12) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.33 Pain Relevance 0.12
The mechanism associated with EPO expression regulation and G-CSF in the present study may be similar to a previously described molecular mechanism involved in VEGF expression regulation and macrophage colony-stimulating factor (M-CSF) in cell monocytes and macrophages [29].
Regulation (regulation) of in macrophages Gene_expression (expression) of factor in monocytes
13) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.33 Pain Relevance 0.12

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