INT15202

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Context Info
Confidence 0.60
First Reported 1991
Last Reported 2010
Negated 6
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 9.65
Pain Relevance 16.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tacr1) plasma membrane (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
spinal cord 1
AMs 1
small intestine 1
neural 1
neurons 1
Tacr1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 328 100.00 Very High Very High Very High
antagonist 120 100.00 Very High Very High Very High
qutenza 69 100.00 Very High Very High Very High
agonist 42 100.00 Very High Very High Very High
Pain 28 100.00 Very High Very High Very High
Antinociceptive 4 99.98 Very High Very High Very High
nociceptor 1 99.80 Very High Very High Very High
Analgesic 5 99.74 Very High Very High Very High
narcan 3 99.42 Very High Very High Very High
Morphine 6 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vomiting 8 99.98 Very High Very High Very High
Targeted Disruption 16 99.96 Very High Very High Very High
Colitis 5 99.64 Very High Very High Very High
Pressure And Volume Under Development 12 99.20 Very High Very High Very High
INFLAMMATION 100 99.12 Very High Very High Very High
Pain 25 98.96 Very High Very High Very High
Cystitis 15 98.80 Very High Very High Very High
Neurogenic Inflammation 6 98.60 Very High Very High Very High
Pulmonary Disease 52 98.44 Very High Very High Very High
Increased Venous Pressure Under Development 11 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NK1R is regulated by many different mechanisms and it may be that near term, in addition to ovarian steroids, other hormonal, humoral, placental or neural influences may influence its expression.
Regulation (regulated) of NK1R in neural
1) Confidence 0.60 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.17 Pain Relevance 0.15
Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema.
Regulation (Effect) of tachykinin receptor in ear associated with pressure and volume under development, qutenza and antagonist
2) Confidence 0.60 Published 1996 Journal Inflamm. Res. Section Title Doc Link 8814463 Disease Relevance 0.41 Pain Relevance 0.92
We studied the importance of SP and NK-1R in this colitis model.
Regulation (importance) of NK-1R associated with colitis and substance p
3) Confidence 0.54 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14500676 Disease Relevance 0.53 Pain Relevance 0.62
The results of this study indicate that NK-1 receptor agonists are not necessarily affected to a same degree by SP analogs containing D-His.
Neg (not) Regulation (affected) of NK-1 receptor associated with agonist and substance p
4) Confidence 0.52 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1717679 Disease Relevance 0 Pain Relevance 0.82
In this context, an up-regulation of NK1R was found in bladder inflammation [20] and bladder biopsies from cystitis patients present an increase in NK1R density [21], nerves [22], and SP-containing fibers [23].
Regulation (regulation) of NK1R in nerves associated with inflammation, cystitis and substance p
5) Confidence 0.47 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 1.42 Pain Relevance 0.84
Postnatal changes in the spatial distributions of substance P and neurokinin-1 receptor in the trigeminal subnucleus caudalis of mice.
Regulation (changes) of neurokinin-1 receptor associated with nociceptor and substance p
6) Confidence 0.45 Published 2005 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 15763273 Disease Relevance 0.27 Pain Relevance 0.66
There was no effect of NK1 receptor blockade with L-760735 in guinea-pigs or GR205171 in rats, or deletion of the NK1 receptor in mice, on behaviour in the elevated plus-maze test for anxiolytic activity.
Neg (no) Regulation (effect) of NK1 receptor associated with anxiety disorder
7) Confidence 0.45 Published 2001 Journal Behav Pharmacol Section Abstract Doc Link 11742144 Disease Relevance 0.44 Pain Relevance 0.34
There was no effect of NK1 receptor blockade with L-760735 in guinea-pigs or GR205171 in rats, or deletion of the NK1 receptor in mice, on behaviour in the elevated plus-maze test for anxiolytic activity.
Neg (no) Regulation (effect) of NK1 receptor associated with anxiety disorder
8) Confidence 0.45 Published 2001 Journal Behav Pharmacol Section Abstract Doc Link 11742144 Disease Relevance 0.44 Pain Relevance 0.33
To investigate the possibility that substance P has a role, as well as 5-HT, in the emetic reflex pathway, we have examined the anti-emetic effects of a NK1 receptor antagonist (racemic CP-99,994) in the ferret.
Spec (examined) Regulation (effects) of NK1 receptor associated with antagonist, vomiting and substance p
9) Confidence 0.44 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7506663 Disease Relevance 0.37 Pain Relevance 0.27
The present results suggest that the difference in effects of the two NK1 receptor antagonists on the oedema response to capsaicin is due to species differences in affinities for the NK1 receptor in the mouse skin.
Regulation (effects) of NK1 receptor in skin associated with pressure and volume under development, qutenza and antagonist
10) Confidence 0.44 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8814463 Disease Relevance 0.42 Pain Relevance 0.75
While capsaicin increased IPSCs in NK1R+/+ mice, it had no effect in NK1R-/- mice (Figure 2d).
Neg (no) Regulation (effect) of NK1R associated with qutenza
11) Confidence 0.44 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0.17 Pain Relevance 1.00
In these animals, NK1R-expressing neurons in deep laminae remain intact or less affected [8,12,24].
Regulation (affected) of NK1R-expressing in neurons
12) Confidence 0.44 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0.51 Pain Relevance 1.14
To conclude, the tachykinin NK1 receptor is involved in the accumulation of inflammatory cells in the airways during the inflammatory response to CS in a mouse model of COPD.
Regulation (involved) of NK1 receptor associated with inflammatory response, pulmonary disease and inflammation
13) Confidence 0.41 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 1.20 Pain Relevance 0.23
Also, differences in duration of the smoke protocol and the resulting strenght of the inflammatory response may be of importance, as we did demonstrate an effect of the NK1 receptor antagonist RP 67580 on the neutrophil accumulation upon short time (2 weeks) CS-exposure.
Regulation (effect) of NK1 receptor in neutrophil associated with inflammatory response and antagonist
14) Confidence 0.41 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.15 Pain Relevance 0.25
Since NK1 receptor agonists differ in their receptor interaction, we set out to compare a range of NK1 receptor agonists including SPOME, septide and GR-73 632 in their effects on propulsive peristalsis and circular muscle activity in the guinea-pig isolated small intestine.
Regulation (range) of NK1 receptor in small intestine associated with agonist
15) Confidence 0.40 Published 2000 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 10877607 Disease Relevance 0.07 Pain Relevance 0.29
Differential effects of substance P analogs on neurokinin 1 receptor agonists in the mouse spinal cord.
Regulation (effects) of neurokinin 1 receptor in spinal cord associated with analgesic, agonist, spinal cord and substance p
16) Confidence 0.38 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1717679 Disease Relevance 0 Pain Relevance 0.95
Here we identify epitopes on the NK1 receptor responsible for the specific binding of CP 96345 by systematic exchange of corresponding segments between the NK1 receptor and the homologous NK3 (neurokinin B) receptor, which does not bind the non-peptide ligand.
Regulation (responsible) of NK1 receptor associated with substance p
17) Confidence 0.31 Published 1993 Journal Nature Section Abstract Doc Link 7681152 Disease Relevance 0.20 Pain Relevance 0.55
The role of the NK1 receptor in airway contraction induced by electrical field stimulation (EFS) was evaluated by comparing the response in NK1 receptor knockout mice (NK1R-/-) with that of NK1 receptor wild-type controls (WT).
Regulation (response) of NK1 receptor associated with targeted disruption
18) Confidence 0.27 Published 2003 Journal Eur. Respir. J. Section Abstract Doc Link 12570101 Disease Relevance 0.10 Pain Relevance 0.13
P4, alone or in combination with E2, was without effect on Tacr1 levels (Fig. 4A).
Neg (without) Regulation (effect) of Tacr1
19) Confidence 0.27 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0
Our results suggest that CS produces AMs' NK1R overexpression primarily by both promoting neurogenic SP release and synergizing NK1R response to neurogenic SP largely via activating NF-kappaB pathway.
Regulation (response) of NK1R in AMs associated with substance p
20) Confidence 0.24 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.58

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