INT152021

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.38
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 55 99.12 Very High Very High Very High
imagery 41 96.68 Very High Very High Very High
spinal inflammation 47 88.80 High High
methotrexate 53 73.12 Quite High
Infliximab 35 72.72 Quite High
Inflammation 22 71.16 Quite High
cytokine 7 61.40 Quite High
abdominal pain 1 53.12 Quite High
Inflammatory marker 5 52.04 Quite High
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 55 99.12 Very High Very High Very High
INFLAMMATION 42 88.80 High High
Disease 52 87.32 High High
Low Back Pain 33 84.48 Quite High
Demyelinating Disease 1 66.44 Quite High
Hypersensitivity 3 65.44 Quite High
Malignant Neoplastic Disease 2 64.32 Quite High
Thrombocytopenia 1 54.36 Quite High
Neutropenia 1 53.64 Quite High
Abdominal Pain 1 53.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This review has summarized the available evidence from randomized controlled trials of IL-6 inhibition in the treatment for RA.
Regulation (controlled) of Negative_regulation (inhibition) of IL-6 associated with rheumatoid arthritis
1) Confidence 0.32 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.71 Pain Relevance 0.32
However, the results of this study do suggest that an early reduction of IL-6 level is important.
Regulation (important) of Negative_regulation (reduction) of IL-6
2) Confidence 0.10 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564765 Disease Relevance 0.67 Pain Relevance 0.66
Serum levels of TNF-alpha, IL-6, and MCP-1 did not reflect the degree of carotid subclinical atherosclerosis.
Neg (not) Regulation (reflect) of Negative_regulation (levels) of IL-6
3) Confidence 0.06 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18487068 Disease Relevance 0 Pain Relevance 0

General Comments

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