INT152023

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Context Info
Confidence 0.52
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.99
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfa) cell proliferation (Vegfa) extracellular space (Vegfa)
growth (Vegfa) extracellular region (Vegfa) plasma membrane (Vegfa)
Anatomy Link Frequency
endothelial cells 1
fibroblast 1
body 1
Vegfa (Mus musculus)
Pain Link Frequency Relevance Heat
endometriosis 1 95.36 Very High Very High Very High
rheumatoid arthritis 1 94.08 High High
cINOD 1 75.00 Quite High
Inflammation 3 68.88 Quite High
cytokine 8 67.84 Quite High
chemokine 2 66.72 Quite High
Kinase C 2 61.28 Quite High
tolerance 4 57.68 Quite High
imagery 12 56.60 Quite High
Inflammatory mediators 1 52.32 Quite High
Disease Link Frequency Relevance Heat
Cancer 370 98.84 Very High Very High Very High
Age-related Macular Degeneration 3 97.76 Very High Very High Very High
Metastasis 7 97.12 Very High Very High Very High
Osteogenic Sarcomas 3 96.52 Very High Very High Very High
Diabetic Retinopathy 11 96.24 Very High Very High Very High
Endometriosis (extended) 1 95.36 Very High Very High Very High
Increased Venous Pressure Under Development 1 94.76 High High
Osteoporosis 4 94.28 High High
Rheumatoid Arthritis 1 94.08 High High
Apoptosis 8 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bisphosphonates are used also to regulate circulating vascular endothelial growth factor (VEGF) concentrations within the body as a prophylactic against cancer metastasis [3].
Regulation (regulate) of vascular endothelial growth factor in body associated with cancer and metastasis
1) Confidence 0.52 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0.39 Pain Relevance 0
The purpose of this study was to examine the effects of cyclooxygenase inhibitors on basic fibroblast growth factor (bFGF)- and vascular endothelial growth factor (VEGF)-mediated ocular neovascularization and permeability.
Spec (examine) Regulation (effects) of vascular endothelial growth factor in fibroblast
2) Confidence 0.36 Published 2008 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 18487370 Disease Relevance 0.90 Pain Relevance 0.17
Their approach relied on using agents that directly target vascular endothelial growth factor (VEGF) or its receptor (VEGFR) on endothelial cells.
Regulation (target) of vascular endothelial growth factor in endothelial cells
3) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716529 Disease Relevance 1.11 Pain Relevance 0.03
Regulation of Vascular Endothelial Growth Factor (VEGF) Splicing from Pro-angiogenic to Anti-angiogenic Isoforms

Vascular endothelial growth factor (VEGF) is produced either as a pro-angiogenic or anti-angiogenic protein depending upon splice site choice in the terminal, eighth exon.

Regulation (Regulation) of Vascular Endothelial Growth Factor
4) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Title Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.03
Regulation of Vascular Endothelial Growth Factor (VEGF) Splicing from Pro-angiogenic to Anti-angiogenic Isoforms

Vascular endothelial growth factor (VEGF) is produced either as a pro-angiogenic or anti-angiogenic protein depending upon splice site choice in the terminal, eighth exon.

Regulation (Regulation) of Vascular endothelial growth factor
5) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Title Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.03
A master regulator of vascular endothelial growth factor, Stat3 is also critical for tumor angiogenesis.
Regulation (regulator) of vascular endothelial growth factor associated with cancer
6) Confidence 0.07 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 1.59 Pain Relevance 0.16

General Comments

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