INT152025

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.21
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm5) plasma membrane (Grm5) cytoplasm (Grm5)
signal transducer activity (Grm5)
Anatomy Link Frequency
CeA 2
synapses 2
Grm5 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 3 100.00 Very High Very High Very High
amygdala 13 99.68 Very High Very High Very High
depression 38 99.12 Very High Very High Very High
antagonist 18 97.64 Very High Very High Very High
Inflammation 2 97.32 Very High Very High Very High
Pain 7 95.36 Very High Very High Very High
Action potential 22 88.16 High High
dopamine receptor 1 81.24 Quite High
Analgesic 1 76.80 Quite High
Glutamate receptor 16 75.00 Quite High
Disease Link Frequency Relevance Heat
Depression 38 99.12 Very High Very High Very High
INFLAMMATION 2 97.32 Very High Very High Very High
Pain 4 95.36 Very High Very High Very High
Hypersensitivity 3 92.96 High High
Nociception 4 82.96 Quite High
Injury 2 82.72 Quite High
Stress 2 74.20 Quite High
Targeted Disruption 7 73.76 Quite High
Anxiety Disorder 1 70.84 Quite High
Fever 1 61.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we demonstrate that phosphorylation of extracellular-signal regulated kinase 1/2 (ERK1/2) is downstream of mGluR5 activation in the CeA and is necessary for the full expression of peripheral inflammation-induced behavioral sensitization.
Negative_regulation (downstream) of Positive_regulation (activation) of mGluR5 in CeA associated with inflammation and amygdala
1) Confidence 0.14 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554871 Disease Relevance 0.99 Pain Relevance 0.76
Activation of mGluRs may downregulate K+ currents, but this downregulation is not sufficient to explain a voltage-dependent ADP as indicated by the ramp current experiments (Figure 7), which show that upregulation of R-type Ca2+ current is required to produce the ADP.
Spec (may) Negative_regulation (downregulate) of Positive_regulation (Activation) of mGluRs
2) Confidence 0.06 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0.07 Pain Relevance 0.07
Thus, as previously described at the PrPFC to nucleus accumbens synapses [28], activation of mGluR5 is necessary to induce eCB-LTD via a yet unidentified eCB that activates presynaptic CB1R.
Negative_regulation (described) of Positive_regulation (activation) of mGluR5 in synapses associated with nucleus accumbens and depression
3) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.87 Pain Relevance 0.73
In conclusion, blockade of mGluR1 showed antipsychotic-like effects without impairing motor functions, whereas blockade of mGluR5 and activation of mGluR2/3 did not display such activities.
Negative_regulation (blockade) of Positive_regulation (activation) of mGluR5
4) Confidence 0.01 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18487514 Disease Relevance 0.27 Pain Relevance 0.50

General Comments

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